Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling

Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis

(2016) Xin Teng et al.   ACS Chemical Biology

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Metabolic control of methylation and acetylation

(2016) Xiaoyang Su et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Hypoxia Induces Production of L-2-Hydroxyglutarate

(2015) Andrew M. Intlekofer et al.   Cell Metabolism

Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

(2015) William M. Oldham et al.   Cell Metabolism

Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation

(2015) Sergiy M. Nadtochiy et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Failure to replicate the STAP cell phenomenon

(2015) Alejandro De Los Angeles et al.   NATURE

Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes

(2015) Yonghui Jin et al.   PLoS One

A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome

(2015) Julie Thompson Legault et al.   Cell Reports

Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents

(2015) Pu Wang et al.   Cell Reports

A Mouse Model of L-2-Hydroxyglutaric Aciduria, a Disorder of Metabolite Repair

(2015) Rim Rzem et al.   PLoS One

Metabolic Modulation of Epigenetics in Gliomas

(2013) Sriram Venneti et al.   BRAIN PATHOLOGY

Mitochondrially targeted nitro-linoleate: a new tool for the study of cardioprotection

(2013) Sergiy M Nadtochiy et al.   BRITISH JOURNAL OF PHARMACOLOGY

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

A metabolic signature for long life in theCaenorhabditis elegansMit mutants

(2012) Jeffrey A. Butler et al.   AGING CELL

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

Acidic stress promotes a glioma stem cell phenotype

(2010) A B Hjelmeland et al.   CELL DEATH AND DIFFERENTIATION

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

(2010) Johanna Chiche et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Erratum: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2010) Lenny Dang et al.   NATURE

Oxygen Sensitivity of Mitochondrial Reactive Oxygen Species Generation Depends on Metabolic Conditions

(2009) David L. Hoffman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

l-2-Hydroxyglutaric aciduria, a disorder of metabolite repair

(2008) E. Van Schaftingen et al.   JOURNAL OF INHERITED METABOLIC DISEASE