Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359

(2018) Javier Rodriguez et al.   Cell Reports

Expanding Proteome Coverage with CHarge Ordered Parallel Ion aNalysis (CHOPIN) Combined with Broad Specificity Proteolysis

(2017) Simon Davis et al.   JOURNAL OF PROTEOME RESEARCH

PHD2 Targeting Overcomes Breast Cancer Cell Death upon Glucose Starvation in a PP2A/B55α-Mediated Manner

(2017) Giusy Di Conza et al.   Cell Reports

An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes

(2017) Dorte B. Bekker-Jensen et al.   Cell Systems

Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways

(2017) Karim Ullah et al.   Scientific Reports

Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling

(2016) Pardeep Heir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

(2016) Mun Chiang Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2

(2016) Natalie J. German et al.   MOLECULAR CELL

pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner

(2016) J. Guo et al.   SCIENCE

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

(2016) Rasheduzzaman Chowdhury et al.   Nature Communications

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

(2016) Javier Rodriguez et al.   Cell Reports

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

(2016) Inmaculada Segura et al.   Cell Reports

A Lactate-Induced Response to Hypoxia

(2015) Dong Chul Lee et al.   CELL

PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban

(2015) Liang Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia

(2015) Claire E. J. Moore et al.   MOLECULAR AND CELLULAR BIOLOGY

HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond

(2015) Patrick H. Maxwell et al.   Nature Reviews Nephrology

Identification of prolyl hydroxylation modifications in mammalian cell proteins

(2015) Patrick R. Arsenault et al.   PROTEOMICS

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

(2014) X. Zheng et al.   GENES & DEVELOPMENT

PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility

(2014) Weibo Luo et al.   MOLECULAR BIOLOGY OF THE CELL

Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1

(2014) Tianshu Feng et al.   MOLECULAR CELL

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation

(2014) John S. Scotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

(2014) R. S. Singleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prolyl 4-hydroxylases, master regulators of the hypoxia response

(2013) J. Myllyharju   Acta Physiologica

PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192

(2013) Sandra C. Moser et al.   DEVELOPMENTAL CELL

Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D

(2012) Zhaoxia Huo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response

(2012) Liang Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparative Proteomic Analysis of Eleven Common Cell Lines Reveals Ubiquitous but Varying Expression of Most Proteins

(2012) Tamar Geiger et al.   MOLECULAR & CELLULAR PROTEOMICS

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Regulation of Cellular Levels of Sprouty2 Protein by Prolyl Hydroxylase Domain and von Hippel-Lindau Proteins

(2011) Kimberly Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation

(2011) Rachelle S. Singleton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors

(2011) Ya-Min Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPA1 underlies a sensing mechanism for O2

(2011) Nobuaki Takahashi et al.   Nature Chemical Biology

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

(2010) Christoph Loenarz et al.   EMBO REPORTS

Bimodal protein solubility distribution revealed by an aggregation analysis of the entire ensemble of Escherichia coli proteins

(2009) T. Niwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxygen-Regulated  2-Adrenergic Receptor Hydroxylation by EGLN3 and Ubiquitylation by pVHL

(2009) L. Xie et al.   Science Signaling

Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases

(2009) Rasheduzzaman Chowdhury et al.   STRUCTURE

The von Hippel-Lindau Tumor Suppressor Protein and Egl-9-Type Proline Hydroxylases Regulate the Large Subunit of RNA Polymerase II in Response to Oxidative Stress

(2008) O. Mikhaylova et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL