Intratumor Heterogeneity and Therapy Resistance: Contributions of Dormancy, Apoptosis Reversal (Anastasis) and Cell Fusion to Disease Recurrence
出版年份 2020 全文链接
标题
Intratumor Heterogeneity and Therapy Resistance: Contributions of Dormancy, Apoptosis Reversal (Anastasis) and Cell Fusion to Disease Recurrence
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 4, Pages 1308
出版商
MDPI AG
发表日期
2020-02-19
DOI
10.3390/ijms21041308
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Apoptotic cell-derived exosomes: messages from dying cells
- (2020) Ramesh Kakarla et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Nonlinearities in the cellular response to ionizing radiation and the role of p53 therein
- (2020) David Murray et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Targeting Cancer Cell Dormancy
- (2019) Ariadna Recasens et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Leukocyte–Cancer Cell Fusion—Genesis of a Deadly Journey
- (2019) Greggory Laberge et al. Cells
- HER2-Targeted Tyrosine Kinase Inhibitors Cause Therapy-Induced-Senescence in Breast Cancer Cells
- (2019) Martina S.J. McDermott et al. Cancers
- Flow Cytometric Detection of Newly-formed Breast Cancer Stem Cell-like Cells After Apoptosis Reversal
- (2019) Yiyue Xu et al. Jove-Journal of Visualized Experiments
- The role of heterogeneous environment and docetaxel gradient in the emergence of polyploid, mesenchymal and resistant prostate cancer cells
- (2019) Ke-Chih Lin et al. CLINICAL & EXPERIMENTAL METASTASIS
- Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer
- (2019) Junsong Chen et al. CURRENT CANCER DRUG TARGETS
- Molecular profiling of anastatic cancer cells: potential role of the nuclear export pathway
- (2019) Mahendra Seervi et al. CELLULAR ONCOLOGY
- Syncytin 1, CD9, and CD47 regulating cell fusion to form PGCCs associated with cAMP/PKA and JNK signaling pathway
- (2019) Fei Fei et al. Cancer Medicine
- Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy
- (2019) Chien-Hsiang Hsu et al. CELL
- Cancer cell fusion: a potential target to tackle drug-resistant and metastatic cancer cells
- (2019) Clara Fernandes et al. DRUG DISCOVERY TODAY
- Tumor Microenvironment and Cell Fusion
- (2019) Erhui Jiang et al. Biomed Research International
- A unique morphological phenotype in chemoresistant triple negative breast cancer reveals metabolic reprogramming and PLIN4 expression as a molecular vulnerability
- (2019) Isabelle Sirois et al. MOLECULAR CANCER RESEARCH
- Polyploid giant cancer cells: Unrecognized actuators of tumorigenesis, metastasis, and resistance
- (2019) Sarah R. Amend et al. PROSTATE
- Formation of Polyploid Giant Cancer Cells Involves in the Prognostic Value of Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer
- (2019) Fei Fei et al. Journal of Oncology
- The Systemic–Evolutionary Theory of the Origin of Cancer (SETOC): A New Interpretative Model of Cancer as a Complex Biological System
- (2019) Antonio Mazzocca INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Adaptive mutability of colorectal cancers in response to targeted therapies
- (2019) Mariangela Russo et al. SCIENCE
- Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents
- (2019) Agnieszka Bojko et al. Cells
- aCLS cancers: Genomic and epigenetic changes transform the cell of origin of cancer into a tumorigenic pathogen of unicellular organization and lifestyle
- (2019) Vladimir F. Niculescu GENE
- Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond
- (2018) Ruya Zhao et al. CANCER AND METASTASIS REVIEWS
- A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity
- (2018) David Díaz-Carballo et al. CANCER RESEARCH
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- (2018) Lorenzo Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells
- (2018) Min Zhou et al. INTERNATIONAL JOURNAL OF CANCER
- The Dualistic Origin of Human Tumors
- (2018) Jinsong Liu SEMINARS IN CANCER BIOLOGY
- Endoreplication: The Good, the Bad, and the Ugly
- (2018) Zhiqiang Shu et al. TRENDS IN CELL BIOLOGY
- Two-Step Senescence-Focused Cancer Therapies
- (2018) Cynthia J. Sieben et al. TRENDS IN CELL BIOLOGY
- Evolution of oncogenic signatures of mutation hotspots in tyrosine kinases supports the atavistic hypothesis of cancer
- (2018) Weiran Chen et al. Scientific Reports
- Apoptosis Reversal Promotes Cancer Stem Cell-Like Cell Formation
- (2018) Yiyue Xu et al. NEOPLASIA
- Roles of Polyploid/Multinucleated Giant Cancer Cells in Metastasis and Disease Relapse Following Anticancer Treatment
- (2018) et al. Cancers
- The Biology and Therapeutic Implications of Tumor Dormancy and Reactivation
- (2018) Amit S. Yadav et al. Frontiers in Oncology
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Senescence and senotherapeutics: a new field in cancer therapy
- (2018) Vassilios Myrianthopoulos et al. PHARMACOLOGY & THERAPEUTICS
- Anastasis: recovery from the brink of cell death
- (2018) Ho Man Tang et al. Royal Society Open Science
- Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival
- (2018) Charles E. Gast et al. Science Advances
- Viability Assessment Following Anticancer Treatment Requires Single-Cell Visualization
- (2018) Razmik Mirzayans et al. Cancers
- Unconventional Ways to Live and Die: Cell Death and Survival in Development, Homeostasis, and Disease
- (2018) Swapna A. Gudipaty et al. Annual Review of Cell and Developmental Biology
- Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer
- (2018) François M. Vallette et al. BIOCHEMICAL PHARMACOLOGY
- To the edge of cell death and back
- (2018) Yi-Nan Gong et al. FEBS Journal
- Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns
- (2018) Soo Jeong Park et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Fate of Fusions
- (2018) Gary Clawson Cells
- Do Multiwell Plate High Throughput Assays Measure Loss of Cell Viability Following Exposure to Genotoxic Agents?
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Multinucleated Giant Cancer Cells Produced in Response to Ionizing Radiation Retain Viability and Replicate Their Genome
- (2017) Razmik Mirzayans et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A molecular signature for anastasis, recovery from the brink of apoptotic cell death
- (2017) Gongping Sun et al. JOURNAL OF CELL BIOLOGY
- Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
- (2017) Matthew J. Hangauer et al. NATURE
- Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors
- (2017) Anna S. Trigos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cell-cell fusion as a mechanism of DNA exchange in cancer
- (2017) Stephen C. Searles et al. Oncotarget
- Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis
- (2017) Ian M Cartwright et al. eLife
- Resistance to cancer chemotherapy as an atavism? (retrospective on DOI 10.1002/bies.201300170)
- (2016) Mark Vincent BIOESSAYS
- Fusion with stem cell makes the hepatocellular carcinoma cells similar to liver tumor-initiating cells
- (2016) Ran Wang et al. BMC CANCER
- Is Senescence Reversible?
- (2016) Shweta Chakradeo et al. CURRENT DRUG TARGETS
- Therapeutic resistance and cancer recurrence mechanisms: Unfolding the story of tumour coming back
- (2016) Mohammad Javad Dehghan Esmatabadi et al. JOURNAL OF BIOSCIENCES
- Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach
- (2016) L Flanagan et al. Cell Death & Disease
- Improving anticancer drug development begins with cell culture: misinformation perpetrated by the misuse of cytotoxicity assays
- (2016) Alan Eastman Oncotarget
- Tumor Budding, Micropapillary Pattern, and Polyploidy Giant Cancer Cells in Colorectal Cancer: Current Status and Future Prospects
- (2016) Shiwu Zhang et al. Stem Cells International
- Premature aging/senescence in cancer cells facing therapy: good or bad?
- (2015) Llilians Calvo Gonzalez et al. BIOGERONTOLOGY
- Tumorigenic hybrids between mesenchymal stem cells and gastric cancer cells enhanced cancer proliferation, migration and stemness
- (2015) Jianguo Xue et al. BMC CANCER
- Radiation-induced homotypic cell fusions of innately resistant glioblastoma cells mediate their sustained survival and recurrence
- (2015) E. Kaur et al. CARCINOGENESIS
- Dormant Cells: The Original Cause of Tumor Recurrence and Metastasis
- (2015) Jie Li et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- Spontaneous γH2AX Foci in Human Solid Tumor-Derived Cell Lines in Relation to p21WAF1 and WIP1 Expression
- (2015) Razmik Mirzayans et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The number of polyploid giant cancer cells and epithelial-mesenchymal transition-related proteins are associated with invasion and metastasis in human breast cancer
- (2015) Fei Fei et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- The reverse evolution from multicellularity to unicellularity during carcinogenesis
- (2015) Han Chen et al. Nature Communications
- A Fraction of CD133+ CNE2 Cells Is Made of Giant Cancer Cells with Morphological Evidence of Asymmetric Mitosis
- (2015) Qingping Jiang et al. Journal of Cancer
- Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
- (2015) Ho Lam Tang et al. Jove-Journal of Visualized Experiments
- Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence
- (2015) Grazyna Mosieniak et al. NEOPLASIA
- Polyploid giant cancer cells with budding and the expression of cyclin E, S-phase kinase-associated protein 2, stathmin associated with the grading and metastasis in serous ovarian tumor
- (2014) Hongcheng Lv et al. BMC CANCER
- Coming Full Circle—From Endless Complexity to Simplicity and Back Again
- (2014) Robert A. Weinberg CELL
- HepG2 cells recovered from apoptosis show altered drug responses and invasiveness
- (2014) Shan-Shan Wang et al. Hepatobiliary & Pancreatic Diseases International
- Caspase 3 Promotes Surviving Melanoma Tumor Cell Growth after Cytotoxic Therapy
- (2014) Anne L. Donato et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Imaging Caspase-3 Activation as a Marker of Apoptosis-Targeted Treatment Response in Cancer
- (2014) Delphine L. Chen et al. MOLECULAR IMAGING AND BIOLOGY
- Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer
- (2014) John M. Pawelek Chinese Journal of Cancer
- Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer
- (2014) Jermaine Coward et al. Frontiers in Oncology
- Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal
- (2013) Jekaterina Erenpreisa et al. Cancer Cell International
- Vital dyes and virtual deaths
- (2013) M Husmann CELL DEATH AND DIFFERENTIATION
- Measuring apoptosis by microscopy and flow cytometry
- (2013) Conor M. Henry et al. METHODS
- Generation of cancer stem-like cells through the formation of polyploid giant cancer cells
- (2013) S Zhang et al. ONCOGENE
- Fusion for Moving
- (2013) G. A. Clawson SCIENCE
- β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity
- (2013) A. Gutierrez et al. Nature Communications
- Spontaneous Formation of Tumorigenic Hybrids between Breast Cancer and Multipotent Stromal Cells Is a Source of Tumor Heterogeneity
- (2012) Germana Rappa et al. AMERICAN JOURNAL OF PATHOLOGY
- p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer
- (2012) James G. Jackson et al. CANCER CELL
- Cell survival, DNA damage, and oncogenic transformation after a transient and reversible apoptotic response
- (2012) Ho Lam Tang et al. MOLECULAR BIOLOGY OF THE CELL
- Cell fusion promotes chemoresistance in metastatic colon carcinoma
- (2012) V Carloni et al. ONCOGENE
- Spontaneous Cancer-Stromal Cell Fusion as a Mechanism of Prostate Cancer Androgen-Independent Progression
- (2012) Ruoxiang Wang et al. PLoS One
- Dying cell clearance and its impact on the outcome of tumor radiotherapy
- (2012) Kirsten Lauber et al. Frontiers in Oncology
- Co-cultivation of murine BMDCs with 67NR mouse mammary carcinoma cells give rise to highly drug resistant cells
- (2011) Christa Nagler et al. Cancer Cell International
- EGF Receptor Inhibition Radiosensitizes NSCLC Cells by Inducing Senescence in Cells Sustaining DNA Double-Strand Breaks
- (2011) M. Wang et al. CANCER RESEARCH
- Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy
- (2011) Qian Huang et al. NATURE MEDICINE
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Senescent cells as a source of inflammatory factors for tumor progression
- (2010) Albert R. Davalos et al. CANCER AND METASTASIS REVIEWS
- A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
- (2010) Sreenath V. Sharma et al. CELL
- Characterization of hybrid cells derived from spontaneous fusion events between breast epithelial cells exhibiting stem-like characteristics and breast cancer cells
- (2010) Thomas Dittmar et al. CLINICAL & EXPERIMENTAL METASTASIS
- Mitochondria and cell death: outer membrane permeabilization and beyond
- (2010) Stephen W. G. Tait et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- MOS, aneuploidy and the ploidy cycle of cancer cells
- (2010) J Erenpreisa et al. ONCOGENE
- Autophagy, senescence and tumor dormancy in cancer therapy
- (2009) David A. Gewirtz Autophagy
- Reversibility of apoptosis in cancer cells
- (2008) H L Tang et al. BRITISH JOURNAL OF CANCER
- Endopolyploidy in irradiated p53-deficient tumour cell lines: Persistence of cell division activity in giant cells expressing Aurora-B kinase
- (2008) Jekaterina Erenpreisa et al. CELL BIOLOGY INTERNATIONAL
- Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy
- (2008) Pierre-Emmanuel Puig et al. CELL BIOLOGY INTERNATIONAL
- Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
- (2008) G Kroemer et al. CELL DEATH AND DIFFERENTIATION
- Ataxia Telangiectasia Mutated and p21CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy
- (2008) E. Crescenzi et al. CLINICAL CANCER RESEARCH
- Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells
- (2008) Malgorzata A. Sliwinska et al. MECHANISMS OF AGEING AND DEVELOPMENT
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started