Imaging Caspase-3 Activation as a Marker of Apoptosis-Targeted Treatment Response in Cancer

Preclinical Assessment of Carboplatin Treatment Efficacy in Lung Cancer by 18F-ICMT-11-Positron Emission Tomography

(2014) Timothy H. Witney et al.   PLoS One

Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP

(2013) Robert J. Ardecky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer

(2013) François Vaillant et al.   CANCER CELL

Temporal and Spatial Evolution of Therapy-Induced Tumor Apoptosis Detected by Caspase-3-Selective Molecular Imaging

(2013) Q.-D. Nguyen et al.   CLINICAL CANCER RESEARCH

Synthesis, 18F-Radiolabeling, and in Vivo Biodistribution Studies of N-Fluorohydroxybutyl Isatin Sulfonamides using Positron Emission Tomography

(2013) Panupun Limpachayaporn et al.   JOURNAL OF MEDICINAL CHEMISTRY

18F-ICMT-11, a Caspase-3-Specific PET Tracer for Apoptosis: Biodistribution and Radiation Dosimetry

(2013) A. Challapalli et al.   JOURNAL OF NUCLEAR MEDICINE

Second mitochondria-derived activator of caspase (SMAC) mimetic potentiates tumor susceptibility toward natural killer cell-mediated killing

(2013) Kerstin Brinkmann et al.   LEUKEMIA & LYMPHOMA

Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism

(2012) Jennifer L. Allensworth et al.   BREAST CANCER RESEARCH AND TREATMENT

Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: Introduction of a hydrophilic group increases potency in a whole cell assay

(2011) Wenhua Chu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment

(2011) Qian Cai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody

(2011) Delphine L. Chen et al.   NUCLEAR MEDICINE AND BIOLOGY

Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types

(2010) Paula J. Kaplan-Lefko et al.   CANCER BIOLOGY & THERAPY

Phase I Trial of Weekly Tigatuzumab, an Agonistic Humanized Monoclonal Antibody Targeting Death Receptor 5 (DR5)

(2010) Andres Forero-Torres et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

LBY135, a novel anti-DR5 agonistic antibody induces tumor cell-specific cytotoxic activity in human colon tumor cell lines and xenografts

(2010) Jing Li et al.   DRUG DEVELOPMENT RESEARCH

From the Gla domain to a novel small-molecule detector of apoptosis

(2009) Avi Cohen et al.   CELL RESEARCH

Design and Synthesis of 2-Amino-4-methylpyridine Analogues as Inhibitors for Inducible Nitric Oxide Synthase and in Vivo Evaluation of [18F]6-(2-Fluoropropyl)-4-methyl-pyridin-2-amine as a Potential PET Tracer for Inducible Nitric Oxide Synthase

(2009) Dong Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography

(2009) Delphine L. Chen et al.   NUCLEAR MEDICINE AND BIOLOGY

[18F]- and [11C]-Labeled N-benzyl-isatin sulfonamide analogues as PET tracers for Apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98

(2009) Dong Zhou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

APOMAB®, a La-Specific Monoclonal Antibody, Detects the Apoptotic Tumor Response to Life-Prolonging and DNA-Damaging Chemotherapy

(2009) Fares Al-Ejeh et al.   PLoS One

Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide

(2009) Q.-D. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design, Synthesis, and Biological Characterization of a Caspase 3/7 Selective Isatin Labeled with 2-[18F]fluoroethylazide

(2008) Graham Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY