Dietary Polyphenols and Gene Expression in Molecular Pathways Associated with Type 2 Diabetes Mellitus: A Review

Hyperglycemia-induced oxidative brain injury: Therapeutic effects of Cola nitida infusion against redox imbalance, cerebellar neuronal insults, and upregulated Nrf2 expression in type 2 diabetic rats

(2019) Ochuko L. Erukainure et al.   FOOD AND CHEMICAL TOXICOLOGY

Polyphenol-rich ethyl acetate fraction isolated from Molineria latifolia ameliorates insulin resistance in experimental diabetic rats via IRS1/AKT activation

(2018) Der Jiun Ooi et al.   BIOMEDICINE & PHARMACOTHERAPY

Polyphenols and Bioavailability: an update

(2018) Hui Teng et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

(2018) N.H. Cho et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Anthocyanins inhibit high glucose-induced renal tubular cell apoptosis caused by oxidative stress in db/db mice

(2018) Jinying Wei et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Pomegranate polyphenols and urolithin A inhibit α-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells

(2018) Francisco Les et al.   JOURNAL OF ETHNOPHARMACOLOGY

The In Vitro Antioxidant Activity and Inhibition of Intracellular Reactive Oxygen Species of Sweet Potato Leaf Polyphenols

(2018) Hongnan Sun et al.   Oxidative Medicine and Cellular Longevity

Beneficial Effect of Jojoba Seed Extracts on Hyperglycemia-Induced Oxidative Stress in RINm5f Beta Cells

(2018) Sahla Belhadj et al.   Nutrients

Aqueous-Methanol Extracts of Orange-Fleshed Sweet Potato (Ipomoea batatas) Ameliorate Oxidative Stress and Modulate Type 2 Diabetes Associated Genes in Insulin Resistant C2C12 Cells

(2018) Taiwo Ayeleso et al.   MOLECULES

Role of Green Macroalgae Enteromorpha Prolifera Polyphenols in the Modulation of Gene Expression and Intestinal Microflora Profiles in Type 2 Diabetic Mice

(2018) Guopeng Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate

(2017) Ángeles Ortega et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Monomeric cocoa catechins enhance β-cell function by increasing mitochondrial respiration

(2017) Thomas J. Rowley et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model

(2017) Rabia Johnson et al.   MOLECULES

Oxidative Stress in Pancreatic Beta Cell Regeneration

(2017) Jingjing Wang et al.   Oxidative Medicine and Cellular Longevity

Pomegranate juice and its main polyphenols exhibit direct effects on amine oxidases from human adipose tissue and inhibit lipid metabolism in adipocytes

(2017) Francisco Les et al.   Journal of Functional Foods

The in vivo hepato-recovery effects of the polyphenol-rich fermented food Xeniji™ on ethanol-induced liver damage

(2017) Noraisyah Zulkawi et al.   RSC Advances

Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury

(2017) Selim Fakhruddin et al.   Journal of Diabetes Research

Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells

(2017) Shalem Modi et al.   Scientific Reports

Tyrosol, an olive oil polyphenol, inhibits ER stress-induced apoptosis in pancreatic β-cell through JNK signaling

(2016) Hyunjung Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Beta-cell mitochondrial carriers and the diabetogenic stress response

(2016) Thierry Brun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Isoflavones, their Glycosides and Glycoconjugates. Synthesis and Biological Activity

(2016) Wies.law Szeja et al.   CURRENT ORGANIC CHEMISTRY

Chemical constituents and health effects of sweet potato

(2016) Sunan Wang et al.   FOOD RESEARCH INTERNATIONAL

Natural polyphenols: An overview

(2016) Munawar Abbas et al.   INTERNATIONAL JOURNAL OF FOOD PROPERTIES

Antidiabetic Potential of Purple and Red Rice (Oryza sativa L.) Bran Extracts

(2016) Stephen M. Boue et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants

(2016)   LANCET

Aspalathin, a dihydrochalconeC-glucoside, protects H9c2 cardiomyocytes against high glucose induced shifts in substrate preference and apoptosis

(2016) Rabia Johnson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?

(2016) Tarique Hussain et al.   Oxidative Medicine and Cellular Longevity

Effect of mulberry leaf (Folium Mori) on insulin resistance via IRS-1/PI3K/Glut-4 signalling pathway in type 2 diabetes mellitus rats

(2016) Shengyu Cai et al.   PHARMACEUTICAL BIOLOGY

Six months of resveratrol supplementation has no measurable effect in type 2 diabetic patients. A randomized, double blind, placebo-controlled trial

(2016) S. Bo et al.   PHARMACOLOGICAL RESEARCH

Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction

(2016) Hadi Khodabandehloo et al.   Translational Research

Where does liver fat go? A possible molecular link between fatty liver and diabetes

(2016) Akihiro Kikuchi et al.   Journal of Diabetes Investigation

Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease

(2016) Alejandra Guillermina Miranda-Díaz et al.   Journal of Diabetes Research

The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents

(2016) Sonia Tucci   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Current prevalence of Type 1 and Type 2 diabetes in adults and children in the UK

(2015) N. Holman et al.   DIABETIC MEDICINE

γ-Oryzanol Protects Pancreatic β-Cells Against Endoplasmic Reticulum Stress in Male Mice

(2015) Chisayo Kozuka et al.   ENDOCRINOLOGY

(−)-Epicatechin attenuates high-glucose-induced inflammation by epigenetic modulation in human monocytes

(2015) Isabel Cordero-Herrera et al.   EUROPEAN JOURNAL OF NUTRITION

Polyphenols in whole rice grain: Genetic diversity and health benefits

(2015) Yafang Shao et al.   FOOD CHEMISTRY

New insights into the bioavailability of red raspberry anthocyanins and ellagitannins

(2015) Iziar A. Ludwig et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of Pomegranate and Orange Juice on Antioxidant Status in Non-Alcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial

(2015) Golnaz Ekhlasi et al.   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

Endogenous and exogenous mediators of quercetin bioavailability

(2015) Yi Guo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cocoa-rich diet attenuates beta cell mass loss and function in young Zucker diabetic fatty rats by preventing oxidative stress and beta cell apoptosis

(2015) Elisa Fernández-Millán et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance andβ-Cell Dysfunction

(2015) Kevin Noel Keane et al.   Oxidative Medicine and Cellular Longevity

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain

(2015) Jian Jiang et al.   TOXICOLOGY LETTERS

Anthocyanins inhibit high-glucose-induced cholesterol accumulation and inflammation by activating LXRα pathway in HK-2 cells

(2015) Huijun Duan et al.   Drug Design Development and Therapy

Myocyte enhancer factor 2C function in skeletal muscle is required for normal growth and glucose metabolism in mice

(2015) Courtney M Anderson et al.   Skeletal Muscle

Type 2 diabetes as a disease of ectopic fat?

(2014) Naveed Sattar et al.   BMC Medicine

Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity

(2014) Michael Rouse et al.   JOURNAL OF ENDOCRINOLOGY

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Ellagic Acid Suppresses Lipid Accumulation by Suppressing Early Adipogenic Events and Cell Cycle Arrest

(2014) Mi-Seon Woo et al.   PHYTOTHERAPY RESEARCH

An in vitro study reveals the nutraceutical potential of punicic acid relevant to diabetes via enhanced GLUT4 expression and adiponectin secretion

(2014) S. S. Anusree et al.   Food & Function

New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

(2014) Hae-Suk Kim et al.   Redox Biology

Catechin Averts Experimental Diabetes Mellitus-Induced Vascular Endothelial Structural and Functional Abnormalities

(2013) Pooja Bhardwaj et al.   Cardiovascular Toxicology

Hyperglycemia-induced Oxidative Stress and its Role in Diabetes Mellitus Related Cardiovascular Diseases

(2013) Teresa Fiorentino et al.   CURRENT PHARMACEUTICAL DESIGN

Antidiabetic and Hypolipidemic Activities ofCurculigo latifoliaFruit:Root Extract in High Fat Fed Diet and Low Dose STZ Induced Diabetic Rats

(2013) Nur Akmal Ishak et al.   Evidence-based Complementary and Alternative Medicine

Rice Brans, Rice Bran Oils, and Rice Hulls: Composition, Food and Industrial Uses, and Bioactivities in Humans, Animals, and Cells

(2013) Mendel Friedman   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A review of the mechanisms and effectiveness of dietary polyphenols in reducing oxidative stress and thrombotic risk

(2013) A. B. Santhakumar et al.   JOURNAL OF HUMAN NUTRITION AND DIETETICS

Activation of PPAR γ and α by Punicic Acid Ameliorates Glucose Tolerance and Suppresses Obesity-Related Inflammation

(2013) Raquel Hontecillas et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Nutrigenomic effects of germinated brown rice and its bioactives on hepatic gluconeogenic genes in type 2 diabetic rats and HEPG2 cells

(2013) Mustapha Umar Imam et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pomegranate and type 2 diabetes

(2013) Saleem Banihani et al.   NUTRITION RESEARCH

Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci

(2012) Richa Saxena et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

Tissue–Specific Insulin Signaling, Metabolic Syndrome, and Cardiovascular Disease

(2012) Christian Rask-Madsen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Antidiabetic Properties of Germinated Brown Rice: A Systematic Review

(2012) Mustapha Umar Imam et al.   Evidence-based Complementary and Alternative Medicine

In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix

(2012) Diana M. Cheng et al.   FOOD CHEMISTRY

Anti-diabetic effects of Centratherum anthelminticum seeds methanolic fraction on pancreatic cells, β-TC6 and its alleviating role in type 2 diabetic rats

(2012) Aditya Arya et al.   JOURNAL OF ETHNOPHARMACOLOGY

Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets indb/dbmice

(2012) Gyeong-Min Do et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus

(2012) Jayesh Kumar Bhatt et al.   NUTRITION RESEARCH

Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential

(2012) C.J.F. Muller et al.   PHYTOMEDICINE

The molecular and enzymatic basis of bitter/non-bitter flavor of citrus fruit: evolution of branch-forming rhamnosyltransferases under domestication

(2012) Ahuva Frydman et al.   PLANT JOURNAL

Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions

(2012) M. Snel et al.   International Journal of Endocrinology

Macrophages and Tissue Injury: Agents of Defense or Destruction?

(2011) Debra L. Laskin et al.   Annual Review of Pharmacology and Toxicology

Endocytosis of Resveratrol via Lipid Rafts and Activation of Downstream Signaling Pathways in Cancer Cells

(2011) Didier Colin et al.   Cancer Prevention Research

Cyanidin-3-O- -Glucoside and Protocatechuic Acid Exert Insulin-Like Effects by Upregulating PPAR  Activity in Human Omental Adipocytes

(2011) B. Scazzocchio et al.   DIABETES

Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction

(2011) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Cinnamon Intake Lowers Fasting Blood Glucose: Meta-Analysis

(2011) Paul A. Davis et al.   JOURNAL OF MEDICINAL FOOD

Espèces réactives de l’oxygène et stress oxydant

(2011) Camille Migdal et al.   M S-MEDECINE SCIENCES

Ameliorating Effects of Fermented Rice Bran Extract on Oxidative Stress Induced by High Glucose and Hydrogen Peroxide in 3T3-L1 Adipocytes

(2011) Dongyeop Kim et al.   PLANT FOODS FOR HUMAN NUTRITION

GLUT4 and UBC9 Protein Expression Is Reduced in Muscle from Type 2 Diabetic Patients with Severe Insulin Resistance

(2011) Ulla Kampmann et al.   PLoS One

Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action

(2011) David Vauzour et al.   Nutrients

Anti-inflammatory/Anti-oxidative Stress Activities and Differential Regulation of Nrf2-Mediated Genes by Non-Polar Fractions of Tea Chrysanthemum zawadskii and Licorice Glycyrrhiza uralensis

(2010) Tien-Yuan Wu et al.   AAPS Journal

Bioavailability of the Polyphenols: Status and Controversies

(2010) Massimo D’Archivio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E β-Cells and Human Islets through a SIRT1-dependent Mechanism

(2010) Laurène Vetterli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulatory Effect of Rice Bran and Phytic Acid on Glucose Metabolism in High Fat-Fed C57BL/6N Mice

(2010) Soo Mi Kim et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin

(2010) Jung-Mi Yun et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Basic biochemical mechanisms behind the health benefits of polyphenols

(2010) Cesar G. Fraga et al.   MOLECULAR ASPECTS OF MEDICINE

Insulin Resistance in Obesity as the Underlying Cause for the Metabolic Syndrome

(2010) Emily J. Gallagher et al.   MOUNT SINAI JOURNAL OF MEDICINE

Molecular Mechanism of Insulin Resistance in Obesity and Type 2 Diabetes

(2010) Kangduk Choi et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding

(2009) Nathan R. Perron et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

(2009) R. A. DeFronzo   DIABETES

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Composition, industrial processing and applications of rice bran γ-oryzanol

(2009) M.J. Lerma-García et al.   FOOD CHEMISTRY

Epigallocatechin Gallate (EGCG) and Rutin Suppress the Glucotoxicity through Activating IRS2 and AMPK Signaling in Rat Pancreatic β Cells

(2009) Erica P. Cai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Influence of Cooking on Anthocyanins in Black Rice (Oryza sativaL.japonicavar. SBR)

(2009) Miki Hiemori et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity

(2009) Kevin Zhe-Yang Xu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Regular Tart Cherry Intake Alters Abdominal Adiposity, Adipose Gene Transcription, and Inflammation in Obesity-Prone Rats Fed a High Fat Diet

(2009) E.M. Seymour et al.   JOURNAL OF MEDICINAL FOOD

Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death

(2008) Chien-Chih Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury

(2008) Michael P. Holt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epigallocatechin gallate (EGCG) attenuates high glucose-induced insulin signaling blockade in human hepG2 hepatoma cells

(2008) Chih-Li Lin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Flavan-3-ols: Nature, occurrence and biological activity

(2007) Patricia M. Aron et al.   MOLECULAR NUTRITION & FOOD RESEARCH