Tissue–Specific Insulin Signaling, Metabolic Syndrome, and Cardiovascular Disease

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

FoxOs Integrate Pleiotropic Actions of Insulin in Vascular Endothelium to Protect Mice from Atherosclerosis

(2012) Kyoichiro Tsuchiya et al.   Cell Metabolism

Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice

(2012) Ding Ai et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature

(2011) Eugene J. Barrett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Accelerated Atherosclerosis in Apoe −/− Mice Heterozygous for the Insulin Receptor and the Insulin Receptor Substrate-1

(2011) Elena V. Galkina et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle

(2011) Tetsuya Kubota et al.   Cell Metabolism

Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis

(2011) Thomas Scherer et al.   Cell Metabolism

Insulin acts in the arcuate nucleus to increase lumbar sympathetic nerve activity and baroreflex function in rats

(2011) Priscila A. Cassaglia et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity

(2011) Akira Mima et al.   KIDNEY INTERNATIONAL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice

(2010) Christian Rask-Madsen et al.   Cell Metabolism

Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function

(2010) Gavin I. Welsh et al.   Cell Metabolism

The metabolic syndrome: time to get off the merry-go-round?

(2010) G. M. Reaven   JOURNAL OF INTERNAL MEDICINE

Lipid-induced insulin resistance: unravelling the mechanism

(2010) Varman T Samuel et al.   LANCET

Sympathetic nervous activation in obesity and the metabolic syndrome—Causes, consequences and therapeutic implications

(2010) Gavin W. Lambert et al.   PHARMACOLOGY & THERAPEUTICS

Myeloid Cell-Restricted Insulin Receptor Deficiency Protects Against Obesity-Induced Inflammation and Systemic Insulin Resistance

(2010) Jan Mauer et al.   PLoS Genetics

Contribution of Impaired Myocardial Insulin Signaling to Mitochondrial Dysfunction and Oxidative Stress in the Heart

(2009) Sihem Boudina et al.   CIRCULATION

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Glucose Effects on Beta-Cell Growth and Survival Require Activation of Insulin Receptors and Insulin Receptor Substrate 2

(2009) A. Assmann et al.   MOLECULAR AND CELLULAR BIOLOGY

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

(2008) Sudha B. Biddinger et al.   Cell Metabolism

Direct Administration of Insulin Into Skeletal Muscle Reveals That the Transport of Insulin Across the Capillary Endothelium Limits the Time Course of Insulin to Activate Glucose Disposal

(2008) J. D. Chiu et al.   DIABETES

Loss of Neuroprotective Survival Signal in Mice Lacking Insulin Receptor Gene in Rod Photoreceptor Cells

(2008) Ammaji Rajala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY