Article
Gastroenterology & Hepatology
Maria Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodriguez, Luis Leiva-Vega, Aranzazu Pintor-Chocano, Daniel Horrillo, Lourdes Hernandez-Cosido, Jorge L. Torres, Eva Novoa, Ruben Nogueiras, Gema Medina-Gomez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio
Summary: Obesity leads to chronic low-grade inflammation, causing diabetes, steatosis, and insulin resistance. Activation of the p38 pathway in macrophages plays a crucial role in this inflammation, suggesting p38 inhibition as a potential treatment for obesity comorbidities. However, lack of p38 activation in myeloid cells worsens high-fat diet-induced obesity, diabetes, and steatosis. Deficient p38 activation increases macrophage IL-12 production, leading to inhibition of hepatic FGF21 and reduction of thermogenesis in the brown fat.
Article
Biochemistry & Molecular Biology
Yan Du, Ding-xiang Li, Dong-yu Lu, Ran Zhang, Yan-lin Zhao, Qiao-qiao Zhong, Shuai Ji, Liang Wang, Dao-quan Tang
Summary: In this study, the effects and underlying mechanisms of mulberry leaf water extract (MLWE) on obesity and lipid metabolism disorders were investigated in high-fat and high-sucrose diet-fed mice. The results showed that MLWE supplementation reduced body weight gain and serum lipid levels, improved hepatic steatosis and lipid accumulation, and modulated genes involved in oxidative stress, inflammation, and lipogenesis. Additionally, MLWE reversed the changes in several lipid mediators from n-3 polyunsaturated fatty acids. These findings suggest that MLWE supplementation plays a role in anti-obesity effects and improvement of lipid metabolism disorders through the ADPN/AMPK pathway, anti-inflammation, anti-oxidation, and n-3 PUFA metabolism.
Article
Food Science & Technology
Dushyant Kshatriya, Lihong Hao, Nicholas T. Bello
Summary: This study found that raspberry ketone has a dose-dependent metabolic signature in white adipose tissue of mice, which is associated with weight control and loss of righting reflex. Raspberry ketone can regulate gene expression related to weight control and metabolic effects in adipose tissue.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Cell Biology
Szu-Yu Liu, Chia-Chang Huang, Shiang-Fen Huang, Tsai-Ling Liao, Nai-Rong Kuo, Ying-Ying Yang, Tzu-Hao Li, Chih-Wei Liu, Ming-Chih Hou, Han-Chieh Lin
Summary: Activation of systemic, renal vessel and renal tissue levels of PPAR gamma by chronic pioglitazone treatment has beneficial effects on endotoxemia-related TNF alpha/NF kappa B-mediated acute and chronic renal inflammation in cirrhosis. This study revealed that normalization of renal and renal arterial levels of PPAR gamma effectively prevented LPS-induced acute and chronic renal dysfunction in cirrhotic ascitic rats.
Article
Pharmacology & Pharmacy
Rasool Haddadi, Mohammad Cheraghi-poor
Summary: This study investigated the analgesic and anti-inflammatory effects of naproxen and pioglitazone, and found that their combined treatment enhanced these effects. The involvement of PPAR-gamma receptor was also noted. Additionally, these drugs reduced the release of inflammatory cytokines and myeloperoxidase activity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Food Science & Technology
Soon-Young Lee, Min-Hee Kim, Chun-Sik Bae, Hyuk Joon Choi, Eui Hyoun Ma, Sung-Jin Park, Seung-Sik Cho, Dae-Hun Park
Summary: By 2030, it is estimated that 20% of females and 14% of males will be obese, which leads to various diseases. The active compounds in unripe C. unshiu peels were identified and their anti-obesity effect was evaluated using 3T3-L1 cells and high-fat diet mice. The study found that a 30% ethanol extract of C. unshiu peels effectively inhibited preadipocyte differentiation through the PPARα-C/EBPα pathway. In animal study, it decreased LDL and leptin levels, suppressed fat accumulation, prevented adipogenesis by controlling PPARα-C/EBPα-FAS, and inhibited inflammation by down-regulating IL-18, IL-13, and TNF-α. C. unshiu shows promise as an anti-obesity medication and anti-inflammatory drug, with narirutin and hesperidin being the supposed active compounds.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Biochemistry & Molecular Biology
Miao Miao, Xue Wang, Tian Liu, Yan-Jie Li, Wen-Qian Yu, Tong-Mei Yang, Shou-Dong Guo
Summary: Atherosclerosis, a major factor of cardiovascular disease, is influenced by inflammation, dyslipidemia, and oxidative stress. Peroxisome proliferator-activated receptors (PPARs), as nuclear receptors, have tissue- and cell-specific expression and regulate genes involved in lipid metabolism, inflammation, and redox homeostasis. Despite controversies, accumulating evidence supports the role of PPAR activation in attenuating atherosclerosis. Recent advances provide valuable insights into the mechanisms of PPAR activation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nutrition & Dietetics
Monique T. Ngo Njembe, Barbara Pachikian, Irina Lobysheva, Nancy Van Overstraeten, Louis Dejonghe, Eleonore Verstraelen, Marine Buchet, Catherine Rasse, Cecile Gardin, Eric Mignolet, Jean-Luc Balligand, Yvan Larondelle
Summary: This study found that consuming eggs enriched with ALA, DHA, RmA, and PunA can significantly reduce waist circumference, improve abdominal obesity, without affecting other metabolic syndrome factors.
Article
Chemistry, Multidisciplinary
Veronica Egas Ortuno, Sunil Pulletikurti, Kollery S. Veena, Ramanarayanan Krishnamurthy
Summary: This study presents a robust synthesis method for cyclic phosphatidic acids (cPAs) and investigates their hydrolytic properties, which could advance the understanding of their biological properties and potential use as components of synthetic cells.
CHEMICAL COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Olga Kaczmarczyk, Agnieszka Dabek-Drobny, Agnieszka Piatek-Guziewicz, Michal Wozniakiewicz, Pawel Pasko, Justyna Dobrowolska-Iwanek, Aneta Wozniakiewicz, Aneta Targosz, Agata Ptak-Belowska, Urszula Szczyrk, Malgorzata Strzalka, Pawel Zagrodzki, Malgorzata Zwolinska-Wcislo
Summary: There is a close relationship between intestinal inflammation and nutrition in patients with inflammatory bowel disease (IBD). Patients with active IBD have poor nutritional status, reduced levels of short-chain fatty acids, and altered expression of tight junction proteins in the intestine.
Article
Endocrinology & Metabolism
Wan Xu, Jingjing Zhang, Jing Xiao
Summary: The selective PDE4 inhibitor Roflumilast was found to suppress adipogenesis and promote lipolysis, showing therapeutic potential in obesity-related diseases in cell culture and mouse models.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Qing Zhang, Cheng-Xun He, Ling-Yu Wang, Die Qian, Dan-Dan Tang, Sheng-Nan Jiang, Wen-Wen Chen, Chun-Jie Wu, Wei Peng
Summary: The study found that hydroxy-alpha-sanshool (HAS) can promote browning of white adipose tissue (WAT) through the regulation of the AMPK/SIRT-1/PPAR gamma signaling pathway, which helps combat obesity.
Article
Orthopedics
Hua-Jun Yu, Lai-Jie Wang, Kai Huang, Qiao-Feng Guo, Bing-Yuan Lin, Yi-Yang Liu, Ming Yu, Gou-Ping Ma
Summary: Osteomyelitis is an inflammatory bone disease with PPAR-gamma downregulation associated with inflammation and progression. PPAR-gamma agonist could serve as a therapeutic strategy to attenuate inflammatory responses.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Hao Yu, Xinxing Gao, Qilai Ge, Wenjun Tai, Xue Hao, Qi Shao, Zhiyuan Fang, Meng Chen, Yuxiang Song, Wenwen Gao, Guowen Liu, Xiliang Du, Xinwei Li
Summary: This study aimed to investigate the effect of TNF-a on adiponectin production in calf adipocytes and to identify the underlying mechanism. The researchers found that TNF-a reduced adiponectin production by attenuating PPAR? transcriptional activity. This suggests that locally elevated levels of TNF-a in adipose tissue may contribute to the decrease in circulating adiponectin in periparturient dairy cows.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Nutrition & Dietetics
Daniel Da Eira, Shailee Jani, Rolando B. Ceddia
Summary: Obesity-inducing diets can increase the levels of viral entry proteins in the lungs, enhancing the infectivity of SARS-CoV-2 in obese individuals. Conversely, a ketogenic diet may potentially reduce infection severity and SARS-CoV-2 migration to other ACE2-expressing tissues by lowering ACE2 and TMPRSS2 levels and exerting an anti-inflammatory effect.
Article
Biotechnology & Applied Microbiology
Shahrul R. Sarbini, Sofia Kolida, Thierry Naeye, Alexandra Einerhand, Yoann Brison, Magali Remaud-Simeon, Pierre Monsan, Glenn R. Gibson, Robert A. Rastall
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2011)
Article
Nutrition & Dietetics
Josep Bassaganya-Riera, Margaret DiGuardo, Montse Climent, Cristina Vives, Adria Carbo, Zeina E. Jouni, Alexandra W. C. Einerhand, Marianne O'Shea, Raquel Hontecillas
BRITISH JOURNAL OF NUTRITION
(2011)
Article
Agriculture, Dairy & Animal Science
A. Ferramosca, V. Savy, A. W. C. Einerhand, V. Zara
JOURNAL OF ANIMAL AND FEED SCIENCES
(2008)
Article
Nutrition & Dietetics
B. Housez, M. Cazaubiel, C. Vergara, J. -M. Bard, A. Adam, A. Einerhand, P. Samuel
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2012)
Article
Nutrition & Dietetics
Josep Bassaganya-Riera, Margaret DiGuardo, Monica Viladomiu, Anibal de Horna, Sandra Sanchez, Alexandra W. C. Einerhand, Lisa Sanders, Raquel Hontecillas
JOURNAL OF NUTRITION
(2011)
Article
Medicine, Research & Experimental
Maria van der Sluis, Janneke Bouma, Audrey Vincent, Anna Velcich, Kermit L. Carraway, Hans A. Bueller, Alexandra W. C. Einerhand, Johannes B. van Goudoever, Isabelle Van Seuningen, Ingrid B. Renes
LABORATORY INVESTIGATION
(2008)
Article
Biochemistry & Molecular Biology
Wilrike J. Pasman, Jos Heimerikx, Carina M. Rubingh, Robin van den Berg, Marianne O'Shea, Luisa Gambelli, Henk F. J. Hendriks, Alexandra W. C. Einerhand, Corey Scott, Hiskias G. Keizer, Louise I. Mennen
LIPIDS IN HEALTH AND DISEASE
(2008)
Article
Multidisciplinary Sciences
Farah Aladin, Alexandra W. C. Einerhand, Janneke Bouma, Sandra Bezemer, Pim Hermans, Danielle Wolvers, Kate Bellamy, Leon G. J. Frenken, Jim Gray, Miren Iturriza-Gomara
Article
Food Science & Technology
Shahrul R. Sarbini, Sofia Kolida, Thierry Naeye, Alexandra W. Einerhand, Glenn R. Gibson, Robert A. Rastall
JOURNAL OF FUNCTIONAL FOODS
(2013)
Article
Microbiology
Gregor Reid, Nicholas Nduti, Wilbert Sybesma, Remco Kort, Tobias R. Kollmann, Rod Adam, Hamadi Boga, Eric M. Brown, Alexandra Einerhand, Hani El-Nezami, Gregory B. Gloor, Irene I. Kavere, Johanna Lindahl, Amee Manges, Wondu Mamo, Rocio Martin, Amy McMillan, Jael Obiero, Pamela A. Ochieng, Arnold Onyango, Stephen Rulisa, Eeva Salminen, Seppo Salminen, Antony Sije, Jonathan R. Swann, William van Treuren, Daniel Waweru, Steve J. Kemp
Article
Food Science & Technology
Tao He, Wolf Rombouts, Alexandra Wilhelmina Carla Einerhand, Natalie Hotrum, Fred van de Velde
Summary: The protein digestion kinetics of goat milk infant formula is more similar to human milk than cow milk infant formula. The differences in physicochemical behavior observed between the formulas may contribute to faster initial protein digestion of goat milk infant formula. Human milk behaves differently from both formulas, providing new insights into the possibilities for improvement of infant formulas.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Review
Nutrition & Dietetics
Alexandra Wilhelmina Carla Einerhand, Carolien Annika van Loo-Bouwman, Gisela Adrienne Weiss, Caiyun Wang, Genna Ba, Qicheng Fan, Baoping He, Gerrit Smit
Summary: This narrative review highlights the potential role of bovine milk protein lactoferrin (LF) in combating COVID-19. LF has been found to exhibit anti-viral, anti-microbial, and immunomodulatory properties, making it a potential candidate for nutritional interventions against SARS-CoV-2 infection and related COVID-19 pathogenesis. In vitro and in vivo studies have explored the mechanisms underlying LF's effects during different phases of SARS-CoV-2 infection.
Review
Nutrition & Dietetics
Elena Zocchi, Raquel Hontecillas, Andrew Leber, Alexandra Einerhand, Adria Carbo, Santina Bruzzone, Nuria Tubau-Juni, Noah Philipson, Victoria Zoccoli-Rodriguez, Laura Sturla, Josep Bassaganya-Riera
FRONTIERS IN NUTRITION
(2017)
Article
Nutrition & Dietetics
Jean-Michel Gaullier, Johan Halse, Hans Olav Hoivik, Kjetil Hoye, Christian Syvertsen, Minna Nurminiemi, Cecilie Hassfeld, Alexandra Einerhand, Marianne O'Shea, Ola Gudmundsen
BRITISH JOURNAL OF NUTRITION
(2007)