标题
The importance of catalytic promiscuity for enzyme design and evolution
作者
关键词
-
出版物
Nature Reviews Chemistry
Volume 3, Issue 12, Pages 687-705
出版商
Springer Science and Business Media LLC
发表日期
2019-11-15
DOI
10.1038/s41570-019-0143-x
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein
- (2019) Inha Cho et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A “Broad Spectrum” Carbene Transferase for Synthesis of Chiral α-Trifluoromethylated Organoborons
- (2019) Lur Alonso-Cotchico et al. ACS Central Science
- A Biocatalytic Platform for Synthesis of Chiral α-Trifluoromethylated Organoborons
- (2019) Xiongyi Huang et al. ACS Central Science
- Asymmetric δ-Lactam Synthesis with a Monomeric Streptavidin Artificial Metalloenzyme
- (2019) Isra S. Hassan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Understanding and Modulating Metalloenzymes with Unnatural Amino Acids, Non-Native Metal Ions, and Non-Native Metallocofactors
- (2019) Evan N. Mirts et al. ACCOUNTS OF CHEMICAL RESEARCH
- Beyond the Second Coordination Sphere: Engineering Dirhodium Artificial Metalloenzymes To Enable Protein Control of Transition Metal Catalysis
- (2019) Jared C. Lewis ACCOUNTS OF CHEMICAL RESEARCH
- LmrR: A Privileged Scaffold for Artificial Metalloenzymes
- (2019) Gerard Roelfes ACCOUNTS OF CHEMICAL RESEARCH
- Directed Evolution of Artificial Metalloenzymes: A Universal Means to Tune the Selectivity of Transition Metal Catalysts?
- (2019) Manfred T. Reetz ACCOUNTS OF CHEMICAL RESEARCH
- Photoenzymatic Catalysis Enables Radical-Mediated Ketone Reduction in Ene-Reductases
- (2019) Braddock A. Sandoval et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Design and evolution of an enzyme with a non-canonical organocatalytic mechanism
- (2019) Ashleigh J. Burke et al. NATURE
- Site-selective enzymatic C‒H amidation for synthesis of diverse lactams
- (2019) Inha Cho et al. SCIENCE
- Chemical Optimization of Whole-Cell Transfer Hydrogenation Using Carbonic Anhydrase as Host Protein
- (2019) Johannes G. Rebelein et al. ACS Catalysis
- The Effect of Cofactor Binding on the Conformational Plasticity of the Biological Receptors in Artificial Metalloenzymes: The Case Study of LmrR
- (2019) Lur Alonso-Cotchico et al. Frontiers in Chemistry
- Optimization of the Turnover in Artificial Enzymes via Directed Evolution Results in the Coupling of Protein Dynamics to Chemistry
- (2019) Joseph W. Schafer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Photoexcitation of flavoenzymes enables a stereoselective radical cyclization
- (2019) Kyle F. Biegasiewicz et al. SCIENCE
- Stereodivergent Evolution of Artificial Enzymes for the Michael Reaction
- (2018) Xavier Garrabou et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- An Artificial Heme Enzyme for Cyclopropanation Reactions
- (2018) Lara Villarino et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Reactivity and Selectivity of Iminium Organocatalysis Improved by a Protein Host
- (2018) Alexander R Nödling et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Directed Evolution of Protein Catalysts
- (2018) Cathleen Zeymer et al. Annual Review of Biochemistry
- Chemoselective Cyclopropanation over Carbene Y–H Insertion Catalyzed by an Engineered Carbene Transferase
- (2018) Eric J. Moore et al. JOURNAL OF ORGANIC CHEMISTRY
- Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases
- (2018) Kyle F. Biegasiewicz et al. Nature Chemistry
- A designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue
- (2018) Ivana Drienovská et al. Nature Chemistry
- Evolving artificial metalloenzymes via random mutagenesis
- (2018) Hao Yang et al. Nature Chemistry
- Catalytic iron-carbene intermediate revealed in a cytochromeccarbene transferase
- (2018) Russell D. Lewis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enzymatic construction of highly strained carbocycles
- (2018) Kai Chen et al. SCIENCE
- E. coli surface display of streptavidin for directed evolution of an allylic deallylase
- (2018) Tillmann Heinisch et al. Chemical Science
- Artificial Metalloenzyme Design with Unnatural Amino Acids and Non-Native Cofactors
- (2018) Yang Yu et al. ACS Catalysis
- Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes
- (2018) Oliver F. Brandenberg et al. ACS Catalysis
- Chimeric Streptavidins as Host Proteins for Artificial Metalloenzymes
- (2018) Michela M. Pellizzoni et al. ACS Catalysis
- Diverse Engineered Heme Proteins Enable Stereodivergent Cyclopropanation of Unactivated Alkenes
- (2018) Anders M. Knight et al. ACS Central Science
- A designed heme-[4Fe-4S] metalloenzyme catalyzes sulfite reduction like the native enzyme
- (2018) Evan N. Mirts et al. SCIENCE
- Directed Evolution of a Designer Enzyme Featuring an Unnatural Catalytic Amino Acid
- (2018) Clemens Mayer et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions
- (2018) Kai Chen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
- (2018) Ruijie K. Zhang et al. NATURE
- Evolution of a highly active and enantiospecific metalloenzyme from short peptides
- (2018) Sabine Studer et al. SCIENCE
- Biocatalytic hydrogen atom transfer: an invigorating approach to free-radical reactions
- (2018) Yuji Nakano et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Manganese(V) Porphycene Complex Responsible for Inert C–H Bond Hydroxylation in a Myoglobin Matrix
- (2017) Koji Oohora et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Importance of Scaffold Flexibility/Rigidity in the Design and Directed Evolution of Artificial Metallo-β-lactamases
- (2017) Woon Ju Song et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Chemoselective, Enzymatic C–H Bond Amination Catalyzed by a Cytochrome P450 Containing an Ir(Me)-PIX Cofactor
- (2017) Paweł Dydio et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Catalytic Cyclopropanation by Myoglobin Reconstituted with Iron Porphycene: Acceleration of Catalysis due to Rapid Formation of the Carbene Species
- (2017) Koji Oohora et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Enantioselective Hydrogen Atom Transfer: Discovery of Catalytic Promiscuity in Flavin-Dependent ‘Ene’-Reductases
- (2017) Braddock A. Sandoval et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Genetically programmed chiral organoborane synthesis
- (2017) S. B. Jennifer Kan et al. NATURE
- Enantioselective, intermolecular benzylic C–H amination catalysed by an engineered iron-haem enzyme
- (2017) Christopher K. Prier et al. Nature Chemistry
- Multidrug resistance regulators (MDRs) as scaffolds for the design of artificial metalloenzymes
- (2017) Manuela Bersellini et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- An algal photoenzyme converts fatty acids to hydrocarbons
- (2017) Damien Sorigué et al. SCIENCE
- Design of an enantioselective artificial metallo-hydratase enzyme containing an unnatural metal-binding amino acid
- (2017) Ivana Drienovská et al. Chemical Science
- Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme
- (2017) Daniel W. Watkins et al. Nature Communications
- Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology: Challenges and Opportunities
- (2016) Tillmann Heinisch et al. ACCOUNTS OF CHEMICAL RESEARCH
- What are the Limitations of Enzymes in Synthetic Organic Chemistry?
- (2016) Manfred T. Reetz CHEMICAL RECORD
- Enantiocomplementary Synthesis of γ-Nitroketones Using Designed and Evolved Carboligases
- (2016) Xavier Garrabou et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Fast Knoevenagel Condensations Catalyzed by an Artificial Schiff-Base-Forming Enzyme
- (2016) Xavier Garrabou et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Abiological catalysis by artificial haem proteins containing noble metals in place of iron
- (2016) Hanna M. Key et al. NATURE
- Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light
- (2016) Megan A. Emmanuel et al. NATURE
- Directed evolution of artificial metalloenzymes for in vivo metathesis
- (2016) Markus Jeschek et al. NATURE
- Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase
- (2016) Richard Obexer et al. Nature Chemistry
- Installing hydrolytic activity into a completely de novo protein framework
- (2016) Antony J. Burton et al. Nature Chemistry
- Library design and screening protocol for artificial metalloenzymes based on the biotin-streptavidin technology
- (2016) Hendrik Mallin et al. Nature Protocols
- Enantioselective synthesis of an ophiobolin sesterterpene via a programmed radical cascade
- (2016) Z. G. Brill et al. SCIENCE
- An artificial metalloenzyme with the kinetics of native enzymes
- (2016) P. Dydio et al. SCIENCE
- Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
- (2016) S. B. Jennifer Kan et al. SCIENCE
- An enantioselective artificial Suzukiase based on the biotin–streptavidin technology
- (2016) Anamitra Chatterjee et al. Chemical Science
- Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases
- (2016) Jan-Ytzen van der Meer et al. Nature Communications
- Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor
- (2016) Kari E. Hernandez et al. ACS Catalysis
- A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates
- (2015) Xavier Garrabou et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Evidence for the Formation of an Enamine Species during Aldol and Michael-type Addition Reactions Promiscuously Catalyzed by 4-Oxalocrotonate Tautomerase
- (2015) Harshwardhan Poddar et al. CHEMBIOCHEM
- Generation, Characterization, and Tunable Reactivity of Organometallic Fragments Bound to a Protein Ligand
- (2015) Hanna M. Key et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design
- (2015) Tillmann Heinisch et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Supramolecular Assembly of Artificial Metalloenzymes Based on the Dimeric Protein LmrR as Promiscuous Scaffold
- (2015) Jeffrey Bos et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Novel artificial metalloenzymes by in vivo incorporation of metal-binding unnatural amino acids
- (2015) Ivana Drienovská et al. Chemical Science
- Mysteries of Metals in Metalloenzymes
- (2014) Crystal E. Valdez et al. ACCOUNTS OF CHEMICAL RESEARCH
- Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran
- (2014) Z. Jane Wang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Highly Diastereoselective and Enantioselective Olefin Cyclopropanation Using Engineered Myoglobin-Based Catalysts
- (2014) Melanie Bordeaux et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Neutralizing the Detrimental Effect of Glutathione on Precious Metal Catalysts
- (2014) Yvonne M. Wilson et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A designed supramolecular protein assembly with in vivo enzymatic activity
- (2014) Woon Ju Song et al. SCIENCE
- P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions
- (2014) Hans Renata et al. Catalysis Science & Technology
- Dynamic multidrug recognition by multidrug transcriptional repressor LmrR
- (2014) Koh Takeuchi et al. Scientific Reports
- Computational Enzyme Design
- (2013) Gert Kiss et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Promiscuous Catalysis of Asymmetric Michael-Type Additions of Linear Aldehydes to β-Nitrostyrene by the Proline-Based Enzyme 4-Oxalocrotonate Tautomerase
- (2013) Yufeng Miao et al. CHEMBIOCHEM
- Biocatalytic Michael-Type Additions of Acetaldehyde to Nitroolefins with the Proline-Based Enzyme 4-Oxalocrotonate Tautomerase Yielding Enantioenriched γ-Nitroaldehydes
- (2013) Edzard M. Geertsema et al. CHEMISTRY-A EUROPEAN JOURNAL
- Radical SAM-mediated methylation reactions
- (2013) Danica Galonić Fujimori CURRENT OPINION IN CHEMICAL BIOLOGY
- C(sp3)–H Bond Hydroxylation Catalyzed by Myoglobin Reconstituted with Manganese Porphycene
- (2013) Koji Oohora et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template
- (2013) Monika M. Meier et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A Dual Anchoring Strategy for the Localization and Activation of Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology
- (2013) Jeremy M. Zimbron et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Precision is essential for efficient catalysis in an evolved Kemp eliminase
- (2013) Rebecca Blomberg et al. NATURE
- A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo
- (2013) Pedro S Coelho et al. Nature Chemical Biology
- Evolution of a designed retro-aldolase leads to complete active site remodeling
- (2013) Lars Giger et al. Nature Chemical Biology
- Human carbonic anhydrase II as host protein for the creation of artificial metalloenzymes: the asymmetric transfer hydrogenation of imines
- (2013) Fabien W. Monnard et al. Chemical Science
- Cytochrome P450-catalyzed insertion of carbenoids into N–H bonds
- (2013) Z. Jane Wang et al. Chemical Science
- The crystal structure of multidrug-resistance regulator RamR with multiple drugs
- (2013) Suguru Yamasaki et al. Nature Communications
- Reconstructing a Missing Link in the Evolution of a Recently Diverged Phosphotriesterase by Active-Site Loop Remodeling
- (2012) Livnat Afriat-Jurnou et al. BIOCHEMISTRY
- Intramolecular Epistasis and the Evolution of a New Enzymatic Function
- (2012) Sajid Noor et al. PLoS One
- Robust design and optimization of retroaldol enzymes
- (2012) Eric A. Althoff et al. PROTEIN SCIENCE
- Iron-Catalyzed Cyclopropanation in 6 M KOH with in Situ Generation of Diazomethane
- (2012) B. Morandi et al. SCIENCE
- Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
- (2012) P. S. Coelho et al. SCIENCE
- Biotinylated Rh(III) Complexes in Engineered Streptavidin for Accelerated Asymmetric C-H Activation
- (2012) T. K. Hyster et al. SCIENCE
- Bridging between Organocatalysis and Biocatalysis: Asymmetric Addition of Acetaldehyde to β-Nitrostyrenes Catalyzed by a Promiscuous Proline-Based Tautomerase
- (2011) Ellen Zandvoort et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Artificial Transfer Hydrogenases for the Enantioselective Reduction of Cyclic Imines
- (2011) Marc Dürrenberger et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- De Novo Enzyme Design Using Rosetta3
- (2011) Florian Richter et al. PLoS One
- Artificial Metalloenzymes Based on the Biotin−Avidin Technology: Enantioselective Catalysis and Beyond
- (2010) Thomas R. Ward ACCOUNTS OF CHEMICAL RESEARCH
- Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
- (2010) Olga Khersonsky and Dan S. Tawfik Annual Review of Biochemistry
- Adding New Chemistries to the Genetic Code
- (2010) Chang C. Liu et al. Annual Review of Biochemistry
- Regioselective Hydroformylation of Styrene Using Rhodium-Substituted Carbonic Anhydrase
- (2010) Qing Jing et al. ChemCatChem
- Artificial Metalloenzymes
- (2010) Fiora Rosati et al. ChemCatChem
- Mutational effects and the evolution of new protein functions
- (2010) Misha Soskine et al. NATURE REVIEWS GENETICS
- Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction
- (2010) J. B. Siegel et al. SCIENCE
- A Novel Semi-biosynthetic Route for Artemisinin Production Using Engineered Substrate-Promiscuous P450BM3
- (2009) Jeffrey A. Dietrich et al. ACS Chemical Biology
- Catalytic Improvement and Evolution of Atrazine Chlorohydrolase
- (2009) C. Scott et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes
- (2009) Paul R. Ortiz de Montellano CHEMICAL REVIEWS
- Stereoselective Hydrogenation of Olefins Using Rhodium-Substituted Carbonic Anhydrase-A New Reductase
- (2009) Qing Jing et al. CHEMISTRY-A EUROPEAN JOURNAL
- Design of functional metalloproteins
- (2009) Yi Lu et al. NATURE
- Protein Dynamism and Evolvability
- (2009) N. Tokuriki et al. SCIENCE
- Artificial Metalloenzymes for Asymmetric Allylic Alkylation on the Basis of the Biotin–Avidin Technology
- (2008) Julien Pierron et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- X-Ray Structure and Designed Evolution of an Artificial Transfer Hydrogenase
- (2008) Marc Creus et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A Novel Type of Monoheme Cytochromec: Biochemical and Structural Characterization at 1.23 Å Resolution ofRhodothermus marinusCytochromec†‡
- (2008) Meike Stelter et al. BIOCHEMISTRY
- Direct Epoxidation inCandida antarcticaLipase B Studied by Experiment and Theory
- (2008) Maria Svedendahl et al. CHEMBIOCHEM
- Structure of the transcriptional regulator LmrR and its mechanism of multidrug recognition
- (2008) Pramod Kumar Madoori et al. EMBO JOURNAL
- Intense Neutral Drifts Yield Robust and Evolvable Consensus Proteins
- (2008) Shimon Bershtein et al. JOURNAL OF MOLECULAR BIOLOGY
- Kemp elimination catalysts by computational enzyme design
- (2008) Daniela Röthlisberger et al. NATURE
- De Novo Computational Design of Retro-Aldol Enzymes
- (2008) L. Jiang et al. SCIENCE
- Characterization of the Peroxidase Activity of CYP119, a Thermostable P450 FromSulfolobus acidocaldarius
- (2007) Kersten S. Rabe et al. CHEMBIOCHEM
- Asymmetric catalytic cyclopropanation reactions in water
- (2007) Irène Nicolas et al. COORDINATION CHEMISTRY REVIEWS
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