Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases
出版年份 2016 全文链接
标题
Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases
作者
关键词
-
出版物
Nature Communications
Volume 7, Issue -, Pages 10911
出版商
Springer Nature
发表日期
2016-03-08
DOI
10.1038/ncomms10911
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Better prediction of functional effects for sequence variants
- (2015) Maximilian Hecht et al. BMC GENOMICS
- Evidence for the Formation of an Enamine Species during Aldol and Michael-type Addition Reactions Promiscuously Catalyzed by 4-Oxalocrotonate Tautomerase
- (2015) Harshwardhan Poddar et al. CHEMBIOCHEM
- Deep mutational scanning: a new style of protein science
- (2014) Douglas M Fowler et al. NATURE METHODS
- Measuring the activity of protein variants on a large scale using deep mutational scanning
- (2014) Douglas M Fowler et al. Nature Protocols
- Demethionylation of Pro-1 variants of 4-oxalocrotonate tautomerase in Escherichia coli by co-expression with an engineered methionine aminopeptidase
- (2014) Bert-Jan Baas et al. FEBS Open Bio
- How good are my data and what is the resolution?
- (2013) Philip R. Evans et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Recent Advances in the Study of Enzyme Promiscuity in the Tautomerase Superfamily
- (2013) Bert-Jan Baas et al. CHEMBIOCHEM
- Promiscuous Catalysis of Asymmetric Michael-Type Additions of Linear Aldehydes to β-Nitrostyrene by the Proline-Based Enzyme 4-Oxalocrotonate Tautomerase
- (2013) Yufeng Miao et al. CHEMBIOCHEM
- Paraldehyde as an Acetaldehyde Precursor in Asymmetric Michael Reactions Promoted by Site-Isolated Incompatible Catalysts
- (2013) Xinyuan Fan et al. CHEMISTRY-A EUROPEAN JOURNAL
- Biocatalytic Michael-Type Additions of Acetaldehyde to Nitroolefins with the Proline-Based Enzyme 4-Oxalocrotonate Tautomerase Yielding Enantioenriched γ-Nitroaldehydes
- (2013) Edzard M. Geertsema et al. CHEMISTRY-A EUROPEAN JOURNAL
- Asymmetric Michael Reaction of Acetaldehyde with Nitroolefins Catalyzed by Highly Water-Compatible Organocatalysts in Aqueous Media
- (2012) Yupu Qiao et al. ADVANCED SYNTHESIS & CATALYSIS
- Promiscuous enzyme-catalyzed Michael addition: synthesis of warfarin and derivatives
- (2012) Bang-Hua Xie et al. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
- The spatial architecture of protein function and adaptation
- (2012) Richard N. McLaughlin Jr et al. NATURE
- One-Pot Synthesis of Spirooxindole Derivatives Catalyzed by Lipase in the Presence of Water
- (2011) She-Jie Chai et al. ADVANCED SYNTHESIS & CATALYSIS
- Bridging between Organocatalysis and Biocatalysis: Asymmetric Addition of Acetaldehyde to β-Nitrostyrenes Catalyzed by a Promiscuous Proline-Based Tautomerase
- (2011) Ellen Zandvoort et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Systematic Screening for Catalytic Promiscuity in 4-Oxalocrotonate Tautomerase: Enamine Formation and Aldolase Activity
- (2011) Ellen Zandvoort et al. CHEMBIOCHEM
- Functionalization of Fe3O4 magnetic nanoparticles for organocatalytic Michael reactions
- (2011) Paola Riente et al. JOURNAL OF MATERIALS CHEMISTRY
- Acidic proteinase from Aspergillus usamii catalyzed Michael addition of ketones to nitroolefins
- (2011) Ke-Ling Xu et al. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
- Silyl Fluoride Electrophiles for the Enantioselective Synthesis of Silylated Pyrrolidine Catalysts
- (2011) Kaleb I. Jentzsch et al. JOURNAL OF ORGANIC CHEMISTRY
- A novel enzymatic tandem process: utilization of biocatalytic promiscuity for high stereoselective synthesis of 5-hydroxyimino-4,5-dihydrofurans
- (2011) Ming-Yu Wu et al. TETRAHEDRON
- Integration, scaling, space-group assignment and post-refinement
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Kinetic and Structural Characterization of a Heterohexamer 4-Oxalocrotonate Tautomerase fromChloroflexus aurantiacusJ-10-fl: Implications for Functional and Structural Diversity in the Tautomerase Superfamily,
- (2010) Elizabeth A. Burks et al. BIOCHEMISTRY
- The lipase-catalyzed asymmetric C–C Michael addition
- (2010) Jian-Feng Cai et al. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
- Mutational effects and the evolution of new protein functions
- (2010) Misha Soskine et al. NATURE REVIEWS GENETICS
- The highly enantioselective Michael addition of ketones to nitrodienes catalyzed by the efficient organocatalyst system of pyrrolidinyl-thioimidazole and chiral thioureido acid
- (2010) Zhao-Bo Li et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- A Highly Selective, Polymer-Supported Organocatalyst for Michael Additions with Enzyme-Like Behavior
- (2009) Esther Alza et al. ADVANCED SYNTHESIS & CATALYSIS
- A Simple Organocatalytic Enantioselective Synthesis of Pregabalin
- (2009) Oriol Bassas et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Directed evolution drives the next generation of biocatalysts
- (2009) Nicholas J Turner Nature Chemical Biology
- Investigation of lipase-catalyzed Michael-type carbon–carbon bond formations
- (2009) Gernot A. Strohmeier et al. TETRAHEDRON
- Asymmetric Michael Reaction of Acetaldehyde Catalyzed by Diphenylprolinol Silyl Ether
- (2008) Yujiro Hayashi et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Catalytic Asymmetric Michael Reactions of Acetaldehyde
- (2008) Patricia García-García et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Tripeptides as Efficient Asymmetric Catalysts for 1,4-Addition Reactions of Aldehydes to Nitroolefins–A Rational Approach
- (2008) Markus Wiesner et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The chemical versatility of the β–α–β fold: Catalytic promiscuity and divergent evolution in the tautomerase superfamily
- (2008) G. J. Poelarends et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- An efficient enantioselective method for asymmetric Michael addition of nitroalkanes to α,β-unsaturated aldehydes
- (2008) Yongcan Wang et al. CHEMICAL COMMUNICATIONS
- Organocatalytic Asymmetric Total Synthesis of (R)-Rolipram and Formal Synthesis of (3S,4R)-Paroxetine
- (2008) Peter S. Hynes et al. ORGANIC LETTERS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started