A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease

The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases

(2019) Mathias L. Richard et al.   Nature Reviews Gastroenterology & Hepatology

Colonic epithelial cell diversity in health and inflammatory bowel disease

(2019) Kaushal Parikh et al.   NATURE

Genetic Factors and the Intestinal Microbiome Guide Development of Microbe-based Therapies for Inflammatory Bowel Diseases

(2019) Louis J. Cohen et al.   GASTROENTEROLOGY

Myeloid‐derived suppressor cells: roles and relations with Th2, Th17 and Treg cells in asthma

(2019) Qingdong Guan et al.   ALLERGY

Effects and Mechanism of Constitutive TL1A Expression on Intestinal Mucosal Barrier in DSS-Induced Colitis

(2019) Mingyue Yang et al.   DIGESTIVE DISEASES AND SCIENCES

Non-classical monocyte homing to the gut via α4β7 integrin mediates macrophage-dependent intestinal wound healing

(2019) Lena Schleier et al.   GUT

IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes

(2019) Rui Sun et al.   GUT

Challenges in IBD Research: Environmental Triggers

(2019) Shuk-Mei Ho et al.   INFLAMMATORY BOWEL DISEASES

Myeloid-Derived Suppressor Cells in Lung Transplantation

(2019) Tobias Heigl et al.   Frontiers in Immunology

Diet Rich in Animal Protein Promotes Pro-inflammatory Macrophage Response and Exacerbates Colitis in Mice

(2019) Klara Kostovcikova et al.   Frontiers in Immunology

TL1A modulates the severity of colitis by promoting Th9 differentiation and IL-9 secretion

(2019) Dong Wang et al.   LIFE SCIENCES

Intestinal macrophages and their interaction with the enteric nervous system in health and Inflammatory Bowel Disease

(2018) Elisa Meroni et al.   Acta Physiologica

A comprehensive review and update on Crohn's disease

(2018) Mahesh Gajendran et al.   DM DISEASE-A-MONTH

Reversing Ongoing Chronic Intestinal Inflammation and Fibrosis by Sustained Block of IL-12 and IL-23 Using a Vaccine in Mice

(2018) Qingdong Guan et al.   INFLAMMATORY BOWEL DISEASES

Th17 plasticity and its relevance to inflammatory bowel disease

(2018) Aito Ueno et al.   JOURNAL OF AUTOIMMUNITY

Urbanization and the gut microbiota in health and inflammatory bowel disease

(2018) Tao Zuo et al.   Nature Reviews Gastroenterology & Hepatology

TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice

(2018) Hui Li et al.   PATHOLOGY RESEARCH AND PRACTICE

CD96 expression determines the inflammatory potential of IL-9–producing Th9 cells

(2018) Katarina Stanko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease

(2018) Arianne C. Richard et al.   PLoS Genetics

Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis

(2018) Jim G. Castellanos et al.   IMMUNITY

Phenotypic and Functional Diversities of Myeloid-Derived Suppressor Cells in Autoimmune Diseases

(2018) Huijuan Ma et al.   MEDIATORS OF INFLAMMATION

Plasmacytoid Dendritic Cells Are Largely Dispensable for the Pathogenesis of Experimental Inflammatory Bowel Disease

(2018) Catherine M. Sawai et al.   Frontiers in Immunology

An Overview of the Innate and Adaptive Immune System in Inflammatory Bowel Disease

(2017) Matthew C. Choy et al.   INFLAMMATORY BOWEL DISEASES

Immunopathophysiology of inflammatory bowel disease: how genetics link barrier dysfunction and innate immunity to inflammation

(2017) Minesh Mehta et al.   Innate Immunity

MDSCs are involved in the protumorigenic potentials of GM-CSF in colitis-associated cancer

(2017) Ning Ma et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease

(2017) Qingdong Guan et al.   MEDIATORS OF INFLAMMATION

Fine-mapping inflammatory bowel disease loci to single-variant resolution

(2017) Hailiang Huang et al.   NATURE

A functional genomics predictive network model identifies regulators of inflammatory bowel disease

(2017) Lauren A Peters et al.   NATURE GENETICS

Gut microbiota and IBD: causation or correlation?

(2017) Josephine Ni et al.   Nature Reviews Gastroenterology & Hepatology

Genetics and Pathogenesis of Inflammatory Bowel Disease

(2016) Ta-Chiang Liu et al.   Annual Review of Pathology-Mechanisms of Disease

Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis

(2016) Maninder Sidhu-Varma et al.   INFLAMMATORY BOWEL DISEASES

Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases

(2016) Kyle T. Dolan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice

(2016) Yungang Wang et al.   Oncotarget

The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation

(2016) Agnieszka M Kabat et al.   eLife

Functional Myeloid-Derived Suppressor Cell Subsets Recover Rapidly after Allogeneic Hematopoietic Stem/Progenitor Cell Transplantation

(2015) Qingdong Guan et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The association of tissue anti-TNF drug levels with serological and endoscopic disease activity in inflammatory bowel disease: the ATLAS study

(2015) Andres J Yarur et al.   GUT

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

IL-9 and its receptor are predominantly involved in the pathogenesis of UC

(2014) Nancy Nalleweg et al.   GUT

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

(2014) Aditya Murthy et al.   NATURE

TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

(2014) Katharina Gerlach et al.   NATURE IMMUNOLOGY

Downregulation of Hematopoietic MUC1 during Experimental Colitis Increases Tumor-Promoting Myeloid-Derived Suppressor Cells

(2013) T. W. Poh et al.   CLINICAL CANCER RESEARCH

Th9 cells: differentiation and disease

(2013) Mark H. Kaplan   IMMUNOLOGICAL REVIEWS

Employing an IL-23 p19 vaccine to block IL-23 ameliorates chronic murine colitis

(2013) Qingdong Guan et al.   Immunotherapy

The Role of Macrophages and Dendritic Cells in the Initiation of Inflammation in IBD

(2013) Erin C. Steinbach et al.   INFLAMMATORY BOWEL DISEASES

Comparison of experimental mouse models of inflammatory bowel disease

(2013) SOO YOUN OH et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

CD14hi HLA-DRdim macrophages, with a resemblance to classical blood monocytes, dominate inflamed mucosa in Crohnˈs disease

(2013) Susanne Thiesen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The role and potential therapeutic application of myeloid-derived suppressor cells in TNBS-induced colitis

(2013) Qingdong Guan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting IL-23 by employing a p40 peptide-based vaccine ameliorates murine allergic skin and airway inflammation

(2012) Q. Guan et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

An IL-17 peptide-based and virus-like particle vaccine enhances the bioactivity of IL-17in vitroandin vivo

(2012) Qingdong Guan et al.   Immunotherapy

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

Tumor Necrosis Factor Blockade for Treatment of Inflammatory Bowel Disease: Efficacy and Safety

(2012) Benjamin Ngo et al.   Current Molecular Pharmacology

Immune and nonimmune components orchestrate the pathogenesis of inflammatory bowel disease

(2011) Silvio Danese   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Anti-TNF therapy: Safety aspects of taking the risk

(2011) Hemda Rosenblum et al.   AUTOIMMUNITY REVIEWS

Intestinal macrophages - specialised adaptation to a unique environment

(2011) Calum C. Bain et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

Autophagy, Microbial Sensing, Endoplasmic Reticulum Stress, and Epithelial Function in Inflammatory Bowel Disease

(2011) Arthur Kaser et al.   GASTROENTEROLOGY

Interleukin-35 Mediates Mucosal Immune Responses That Protect Against T-Cell–Dependent Colitis

(2011) Stefan Wirtz et al.   GASTROENTEROLOGY

Experimental Inflammatory Bowel Disease: Insights into the Host-Microbiota Dialog

(2011) Maya Saleh et al.   IMMUNITY

Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory bowel disease

(2011) Gheorghe Hundorfean et al.   INFLAMMATORY BOWEL DISEASES

Myeloid derived suppressor cells in human diseases

(2011) Tim F. Greten et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ex Vivo IL-1 Receptor Type I Expression in Human CD4 + T Cells Identifies an Early Intermediate in the Differentiation of Th17 from FOXP3 + Naive Regulatory T Cells

(2011) Caroline Raffin et al.   JOURNAL OF IMMUNOLOGY

Mucosal Macrophages in Intestinal Homeostasis and Inflammation

(2011) Allan McI Mowat et al.   Journal of Innate Immunity

Unknown

(2011) Qingdong Guan et al.   MOLECULAR MEDICINE

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease

(2011) W Strober et al.   Mucosal Immunology

Free radical-producing myeloid-derived regulatory cells: potent activators and suppressors of lung inflammation and airway hyperresponsiveness

(2011) J Deshane et al.   Mucosal Immunology

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Environmental influences on T regulatory cells in inflammatory bowel disease

(2011) Gijs Hardenberg et al.   SEMINARS IN IMMUNOLOGY

Recent advances in cytokines: Therapeutic implications for inflammatory bowel diseases

(2011) Guillaume Bouguen   WORLD JOURNAL OF GASTROENTEROLOGY

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Inflammatory bowel disease—From mechanisms to treatment strategies

(2010) Silvia Melgar et al.   AUTOIMMUNITY

What is new with Nods?

(2010) Joao G Magalhaes et al.   CURRENT OPINION IN IMMUNOLOGY

CD4+CD25+ Regulatory T Cells Suppress Th17-Responses in an Experimental Colitis Model

(2010) Haruei Ogino et al.   DIGESTIVE DISEASES AND SCIENCES

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

(2010) Philip P. Ahern et al.   IMMUNITY

Regulation of intestinal homeostasis by dendritic cells

(2010) Hiroyuki Tezuka et al.   IMMUNOLOGICAL REVIEWS

Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors

(2010) Jinfang Zhu et al.   IMMUNOLOGICAL REVIEWS

IL-23/IL-17 axis in IBD

(2010) Massimiliano Sarra et al.   INFLAMMATORY BOWEL DISEASES

Intestinal dendritic cells

(2010) S. C. Ng et al.   INFLAMMATORY BOWEL DISEASES

New pathophysiological insights and modern treatment of IBD

(2010) Matthias A. Engel et al.   JOURNAL OF GASTROENTEROLOGY

Identification of an Autophagy Defect in Smokers' Alveolar Macrophages

(2010) M. M. Monick et al.   JOURNAL OF IMMUNOLOGY

TLR4/MyD88-induced CD11b+Gr-1intF4/80+ non-migratory myeloid cells suppress Th2 effector function in the lung

(2010) M Arora et al.   Mucosal Immunology

The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation

(2010) F Meylan et al.   Mucosal Immunology

IL-35-mediated induction of a potent regulatory T cell population

(2010) Lauren W Collison et al.   NATURE IMMUNOLOGY

The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models

(2010) Sandra Nell et al.   NATURE REVIEWS MICROBIOLOGY

Human ROR t+ TH17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineage-specific polarizing factors

(2010) D. Valmori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

(2010) Thomas Condamine et al.   TRENDS IN IMMUNOLOGY

IL-1β and IL-2 convert human Treg into TH17 cells

(2009) Florence Deknuydt et al.   CLINICAL IMMUNOLOGY

Therapeutic targeting of myeloid-derived suppressor cells

(2009) Stefano Ugel et al.   CURRENT OPINION IN PHARMACOLOGY

Environmental Factors Affecting Inflammatory Bowel Disease: Have We Made Progress?

(2009) Peter Laszlo Lakatos   DIGESTIVE DISEASES

Th1/Th17 Immune Response Is Induced by Mesenteric Lymph Node Dendritic Cells in Crohn's Disease

(2009) Atsushi Sakuraba et al.   GASTROENTEROLOGY

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

Differential regulation of interleukin 17 and interferon   production in inflammatory bowel disease

(2009) L. Rovedatti et al.   GUT

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

(2009) Maria A. Curotto de Lafaille et al.   IMMUNITY

TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohnʼs disease

(2009) Nobuhiko Kamada et al.   INFLAMMATORY BOWEL DISEASES

Targeting TGF-β1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitis

(2009) Yanbing Ma et al.   INFLAMMATORY BOWEL DISEASES

Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease

(2009) Nicola Eastaff-Leung et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Dendritic cells in intestinal homeostasis and disease

(2009) Maria Rescigno et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Nod2 in the development of Crohn's disease

(2009) Soichiro Yamamoto et al.   MICROBES AND INFECTION

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

IBD-Associated TL1A Gene (TNFSF15) Haplotypes Determine Increased Expression of TL1A Protein

(2009) Kathrin S. Michelsen et al.   PLoS One

Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor ROR t

(2009) M. Ayyoub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of IL-17-producing FOXP3+ regulatory T cells in humans

(2009) K. S. Voo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of recombinant vaccines against IL-12/IL-23 p40 and in vivo evaluation of their effects in the downregulation of intestinal inflammation in murine colitis

(2009) Qingdong Guan et al.   VACCINE

Enhancement of IL-10 bioactivity using an IL-10 peptide-based vaccine exacerbates Leishmania major infection and improves airway inflammation in mice

(2009) Gang Zhou et al.   VACCINE

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

(2008) H. J. P. M. Koenen et al.   BLOOD

Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21

(2008) Daniele Fina et al.   GASTROENTEROLOGY

Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease: A New Immunoregulatory Pathway

(2008) Lydia A. Haile et al.   GASTROENTEROLOGY

TL1A (TNFSF15) Regulates the Development of Chronic Colitis by Modulating Both T-Helper 1 and T-Helper 17 Activation

(2008) Hidetoshi Takedatsu et al.   GASTROENTEROLOGY

Smad7 Controls Resistance of Colitogenic T Cells to Regulatory T Cell-Mediated Suppression

(2008) Massimo C. Fantini et al.   GASTROENTEROLOGY

The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease

(2008) Megan E. Himmel et al.   IMMUNOLOGY

Monocyte-derived dendritic cells from Crohn patients show differential NOD2/CARD15-dependent immune responses to bacteria

(2008) Valentina Salucci et al.   INFLAMMATORY BOWEL DISEASES

Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: Inconsistent correlation between forkhead box protein 3 expression and disease severity

(2008) Eleonora Gambineri et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis

(2008) Nobuhiko Kamada et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of inflammatory responses by IL-17F

(2008) Xuexian O. Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-6–dependent spontaneous proliferation is required for the induction of colitogenic IL-17–producing CD8+T cells

(2008) Masaki Tajima et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

(2008) Bhanu P. Pappu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New therapeutic strategies for treatment of inflammatory bowel disease

(2008) R Atreya et al.   Mucosal Immunology

The molecular basis of NOD2 susceptibility mutations in Crohn's disease

(2008) W Strober et al.   Mucosal Immunology

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages

(2008) Santhakumar Manicassamy et al.   SEMINARS IN IMMUNOLOGY