Inflammatory bowel disease—From mechanisms to treatment strategies

NOD2-Deficient Mice Have Impaired Resistance to Mycobacterium tuberculosis Infection through Defective Innate and Adaptive Immunity

(2014) M. Divangahi et al.   JOURNAL OF IMMUNOLOGY

Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes

(2014) J. Pene et al.   JOURNAL OF IMMUNOLOGY

The Utility of Probiotics in the Treatment of Irritable Bowel Syndrome: A Systematic Review

(2009) Darren M Brenner et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Vexed Relationship Between Clostridium Difficile and Inflammatory Bowel Disease: An Assessment of Carriage in an Outpatient Setting Among Patients in Remission

(2009) Evelyn M Clayton et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Crohn’s Disease: an Immune Deficiency State

(2009) Daniel J. B. Marks et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The immunopathogenesis of Crohn's disease: a three-stage model

(2009) Gavin W Sewell et al.   CURRENT OPINION IN IMMUNOLOGY

Novel cytokine-targeted therapies and intestinal inflammation

(2009) Maximilian J Waldner et al.   CURRENT OPINION IN PHARMACOLOGY

Clostridium Difficile and Inflammatory Bowel Disease

(2009) Ashwin N. Ananthakrishnan et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis

(2009) E A M Festen et al.   GUT

Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis

(2009) E Gonzalez-Rey et al.   GUT

Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

(2009) Andrew M. Smith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

(2009) Melanie A. Kleinschek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: The Foxp3 Target miR-155 Contributes to the Development of Regulatory T Cells

(2009) S. Kohlhaas et al.   JOURNAL OF IMMUNOLOGY

Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity

(2009) Takashi Yabana et al.   JOURNAL OF PATHOLOGY

Therapeutic Effect of Blocking CXCR2 on Neutrophil Recruitment and Dextran Sodium Sulfate-Induced Colitis

(2009) S. M. Farooq et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Therapeutic implications of manipulating and mining the microbiota

(2009) Fergus Shanahan   JOURNAL OF PHYSIOLOGY-LONDON

Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project

(2009) Kenneth R Carson et al.   LANCET ONCOLOGY

Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis

(2009) K Vandenbroucke et al.   Mucosal Immunology

Ulcerative colitis–risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study

(2009) Mark S Silverberg et al.   NATURE GENETICS

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

(2009) Changsheng Du et al.   NATURE IMMUNOLOGY

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF

(2009) Jesper Worm et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells

(2009) Maurizio Ceppi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla

(2009) M. A. Mahowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease

(2009) J. Mattes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of stem cell transplantation in inflammatory bowel disease

(2008) P. J. Fortun et al.   AUTOIMMUNITY

Host-bacteria interaction in inflammatory bowel disease

(2008) P. Knight et al.   BRITISH MEDICAL BULLETIN

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Treatment of Active Crohn's Disease With MLN0002, a Humanized Antibody to the α4β7 Integrin

(2008) Brian G. Feagan et al.   Clinical Gastroenterology and Hepatology

Therapy of ulcerative colitis: state of the art

(2008) Oliver Brain et al.   CURRENT OPINION IN GASTROENTEROLOGY

MicroRNAs Are Differentially Expressed in Ulcerative Colitis and Alter Expression of Macrophage Inflammatory Peptide-2α

(2008) Feng Wu et al.   GASTROENTEROLOGY

Microbial Influences in Inflammatory Bowel Diseases

(2008) R. Balfour Sartor   GASTROENTEROLOGY

Adipose-Derived Mesenchymal Stem Cells Alleviate Experimental Colitis by Inhibiting Inflammatory and Autoimmune Responses

(2008) Manuel A. González et al.   GASTROENTEROLOGY

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

(2008) T Kobayashi et al.   GUT

The role of the novel Th17 cytokine IL-26 in intestinal inflammation

(2008) J Dambacher et al.   GUT

Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases

(2008) C. N Bernstein et al.   GUT

Th17 Cell Differentiation: The Long and Winding Road

(2008) Mandy J. McGeachy et al.   IMMUNITY

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

(2008) Ana Izcue et al.   IMMUNITY

Leukocyte adhesion molecules in animal models of inflammatory bowel disease

(2008) Jesús Rivera-Nieves et al.   INFLAMMATORY BOWEL DISEASES

Hepatocyte nuclear factor 4α in the intestinal epithelial cells protects against inflammatory bowel disease

(2008) Sung-Hoon Ahn et al.   INFLAMMATORY BOWEL DISEASES

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease

(2008) Mark M.W. Chong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice

(2008) Allisson Freire Bento et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Why are MSCs therapeutic? New data: new insight

(2008) AI Caplan   JOURNAL OF PATHOLOGY

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

(2008) Andre Franke et al.   NATURE GENETICS

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

(2008) Sheila A Fisher et al.   NATURE GENETICS

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

(2008) Steven A McCarroll et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Impaired Autophagy of an Intracellular Pathogen Induced by a Crohn's Disease Associated ATG16L1 Variant

(2008) Petric Kuballa et al.   PLoS One

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Homeostasis by the Homeobox Gene Caudal and Commensal-Gut Mutualism in Drosophila

(2008) J.-H. Ryu et al.   SCIENCE

Detection of Mycobacterium avium subspecies paratuberculosis from patients with Crohnʼs disease using nucleic acid-based techniques: A systematic review and meta-analysis

(2007) I. Abubakar et al.   INFLAMMATORY BOWEL DISEASES

Muramyl dipeptide–induced differential gene expression in NOD2 mutant and wild-type crohnʼs disease patient–derived dendritic cells

(2007) Zuzana Zelinkova et al.   INFLAMMATORY BOWEL DISEASES

A small molecule, orally active, α4β1/α4β7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats

(2006) Julio Cortijo et al.   BRITISH JOURNAL OF PHARMACOLOGY