期刊
ONCOTARGET
卷 7, 期 13, 页码 15356-15368出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.7324
关键词
inflammatory bowel disease; exosomes; myeloid-derived suppressor cells; inflammation; Immunology and Microbiology Section; Immune response; Immunity
资金
- Jiangsu Province 333 Project [BRA2015197]
- National Natural Science Foundation of China [31470881, 31170849]
- Specialized Project for Clinical Medicine of Jiangsu Province [BL2014065]
- Natural Science Foundation of Jiangsu [BK20150533]
- Specialized Research Fund for the Doctoral Program of Higher Education [20133227110008]
- Health Department Foundation of Jiangsu Province [Z201312]
- Science and Technology Support Program (Social Development) of Zhenjiang [SH2014039]
- Summit of the Six Top Talents Program of Jiangsu Province [2015-WSN-116]
- Jiangsu University Science Foundation [15JDG070, 11JDG093, FCJJ2015022]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Myeloid-derived suppressor cells (MDSC) have been described in inflammatory bowel disease (IBD), but their role in the disease remains controversial. We sought to define the effect of granulocytic MDSC-derived exosomes (G-MDSC exo) in dextran sulphate sodium (DSS)-induced murine colitis. G-MDSC exo-treated mice showed greater resistance to colitis, as reflected by lower disease activity index, decreased inflammatory cell infiltration damage. There was a decrease in the proportion of Th1 cells and an increase in the proportion of regulatory T cells (Tregs) in mesenteric lymph nodes (MLNs) from G-MDSC exo-treated colitis mice. Moreover, lower serum levels of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha were detected in G-MDSC exo-treated colitis mice. Interestingly, inhibition of arginase (Arg)-1 activity in G-MDSC exo partially abrogated the spontaneous improvement of colitis. In addition, G-MDSC exo could suppress CD4(+) T cell proliferation and IFN-gamma secretion in vitro and inhibit the delayed-type hypersensitivity (DTH) response, and these abilities were associated with Arg-1 activity. Moreover, G-MDSC exo promoted the expansion of Tregs in vitro. Taken together, these results suggest that G-MDSC exo attenuate DSS-induced colitis through inhibiting Th1 cells proliferation and promoting Tregs expansion.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据