A functional genomics predictive network model identifies regulators of inflammatory bowel disease

Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease

(2016) Qi Li et al.   GASTROENTEROLOGY

Rac Attack: Modulation of the Small GTPase Rac in Inflammatory Bowel Disease and Thiopurine Therapy

(2016) Margien L. Seinen et al.   Molecular Diagnosis & Therapy

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells

(2016) E. L. Soucie et al.   SCIENCE

A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity

(2015) Bao H. Duong et al.   IMMUNITY

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections

(2015) Kerry Dobbs et al.   NEW ENGLAND JOURNAL OF MEDICINE

JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles

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Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis

(2015) Stacey N. Harbour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allograft inflammatory factor-1 stimulates chemokine production and induces chemotaxis in human peripheral blood mononuclear cells

(2014) Masatoshi Kadoya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Significance of IL-1RA Polymorphism in Iranian Patients with Inflammatory Bowel Disease

(2014) Nasser Ebrahimi Daryani et al.   DIGESTIVE DISEASES AND SCIENCES

Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data

(2014) G.-B. Chen et al.   HUMAN MOLECULAR GENETICS

Comprehensive Intestinal T Helper Cell Profiling Reveals Specific Accumulation of IFN-γ+IL-17+Coproducing CD4+ T Cells in Active Inflammatory Bowel Disease

(2014) Anna-Maria Globig et al.   INFLAMMATORY BOWEL DISEASES

G Protein Signaling Modulator-3 Inhibits the Inflammasome Activity of NLRP3

(2014) Patrick M. Giguère et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

(2014) Yael Haberman et al.   JOURNAL OF CLINICAL INVESTIGATION

DOCK2 and DOCK5 Act Additively in Neutrophils To Regulate Chemotaxis, Superoxide Production, and Extracellular Trap Formation

(2014) Mayuki Watanabe et al.   JOURNAL OF IMMUNOLOGY

DOK3 Is Required for IFN-β Production by Enabling TRAF3/TBK1 Complex Formation and IRF3 Activation

(2014) Susana Soo-Yeon Kim et al.   JOURNAL OF IMMUNOLOGY

Essential Role of Elmo1 in Dock2-Dependent Lymphocyte Migration

(2014) C. Stevenson et al.   JOURNAL OF IMMUNOLOGY

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands

(2014) X. Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

(2014) A. Mortha et al.   SCIENCE

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

(2014) Sarah Kim et al.   Nature Communications

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation

(2013) Y. Sakai et al.   BLOOD

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Role of AIF-1 in the regulation of inflammatory activation and diverse disease processes

(2013) Yan-Ying Zhao et al.   CELLULAR IMMUNOLOGY

Genetic inactivation of the allograft inflammatory factor-1 locus

(2013) Isabel Casimiro et al.   GENESIS

Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: a phase II randomised study

(2013) Lloyd Mayer et al.   GUT

The Role of Macrophages and Dendritic Cells in the Initiation of Inflammation in IBD

(2013) Erin C. Steinbach et al.   INFLAMMATORY BOWEL DISEASES

Rac2-Deficiency Leads to Exacerbated and Protracted Colitis in Response to Citrobacter rodentium Infection

(2013) Ramzi Fattouh et al.   PLoS One

RNA-SeQC: RNA-seq metrics for quality control and process optimization

(2012) David S. DeLuca et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro

(2012) Yoshiko Onozawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense

(2012) Melissa A. Kinnebrew et al.   IMMUNITY

Receptor Signaling Lymphocyte-activation Molecule Family 1 (Slamf1) Regulates Membrane Fusion and NADPH Oxidase 2 (NOX2) Activity by Recruiting a Beclin-1/Vps34/Ultraviolet Radiation Resistance-associated Gene (UVRAG) Complex

(2012) Chunyan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LAPTM5 Protein Is a Positive Regulator of Proinflammatory Signaling Pathways in Macrophages

(2012) Wioletta K. Glowacka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Dok-3/Grb2 Protein Signal Module Attenuates Lyn Kinase-dependent Activation of Syk Kinase in B Cell Antigen Receptor Microclusters

(2012) Marion Lösing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis

(2012) Patrick M. Giguère et al.   MOLECULAR IMMUNOLOGY

Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers

(2012) I.-M. Wang et al.   Molecular Systems Biology

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

DOK3 Negatively Regulates LPS Responses and Endotoxin Tolerance

(2012) Qisheng Peng et al.   PLoS One

Regulation of the Formyl Peptide Receptor 1 (FPR1) Gene in Primary Human Macrophages

(2012) Claudio Gemperle et al.   PLoS One

GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals

(2012) A. R. Shenoy et al.   SCIENCE

Stitching together Multiple Data Dimensions Reveals Interacting Metabolomic and Transcriptomic Networks That Modulate Cell Regulation

(2012) Jun Zhu et al.   PLOS BIOLOGY

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

(2012) Eimear E. Kenny et al.   PLoS Genetics

Single Nucleotide Polymorphisms That Increase Expression of the Guanosine Triphosphatase RAC1 Are Associated With Ulcerative Colitis

(2011) Aleixo M. Muise et al.   GASTROENTEROLOGY

NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant inNCF2that results in reduced binding to RAC2

(2011) Aleixo M Muise et al.   GUT

An Evolutionary Analysis of RAC2 Identifies Haplotypes Associated with Human Autoimmune Diseases

(2011) M. Sironi et al.   MOLECULAR BIOLOGY AND EVOLUTION

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Intestinal CD103+ dendritic cells: master regulators of tolerance?

(2011) Charlotte L. Scott et al.   TRENDS IN IMMUNOLOGY

Unraveling the Genetics of Autoimmunity

(2010) Lauren A. Zenewicz et al.   CELL

Hem-1: Putting the “WAVE” into actin polymerization during an immune response

(2010) Heon Park et al.   FEBS LETTERS

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation

(2010) Kazuhito Gotoh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Autoimmune Disease Classification by Inverse Association with SNP Alleles

(2009) Marina Sirota et al.   PLoS Genetics

A point mutation in the murineHem1gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity

(2008) Heon Park et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE

Genetics of gene expression and its effect on disease

(2008) Valur Emilsson et al.   NATURE

Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks

(2008) Jun Zhu et al.   NATURE GENETICS

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

(2008) Stephanie L Sanos et al.   NATURE IMMUNOLOGY