Article
Biology
Dong Hyun Kim, Hee Young Kim, Sunjung Cho, Su-Jin Yoo, Won-Ju Kim, Hye Ran Yeon, Kyungho Choi, Je-Min Choi, Seong Wook Kang, Won-Woo Lee
Summary: The study demonstrates the crucial role of IL-1RII receptor in regulating IL-17 responses, affecting the functionality of CD4(+) T cells by limiting IL-1 beta responsiveness.
Article
Biochemistry & Molecular Biology
Laura Perucho, Laura Icardi, Elisabetta Di Simone, Veronica Basso, Alessandra Agresti, Amaia Vilas Zornoza, Teresa Lozano, Felipe Prosper, Juan Jose Lasarte, Anna Mondino
Summary: Sin3A plays a crucial role in regulating the differentiation of Th17 cells and the development of lymphocytes.
Article
Multidisciplinary Sciences
Michael Crawford, Nicholas Borcherding, Nitin Karandikar
Summary: CD4(+) T-helper 17 (Th17) T cells play a crucial role in promoting inflammation through the secretion of IL-17 and are a major therapeutic target for autoimmune disorders. Recent studies have shown that IL-17 family cytokines can directly act on CD4(+) T cells, specifically naive cells, leading to functional changes. The differences in downstream signaling and functional consequences suggest that IL-17AF heterodimer is the most influential cytokine.
Article
Immunology
Shaokui Chen, Zibei Lin, Tianzhen He, Md Sahidul Islam, Long Xi, Ping Liao, Yang Yang, Ying Zheng, Xin Chen
Summary: There is evidence that topical administration of TET nanoemulsion can stimulate the expansion of Tregs through the TNF-TNFR2 pathway and inhibit the development of psoriasis-like disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Laura A. Shaw, Tianda Z. Deng, Kyla D. Omilusik, Kennidy K. Takehara, Quynh P. Nguyen, Ananda W. Goldrath
Summary: CD4(+) T cells are important in vaccine development, but the existence of multiple helper subsets complicates the identification of memory precursor cells. Recent research has found that the expression of Id3 can identify a subset of CD4(+) T cells with memory potential, which exhibit significant re-expansion in response to secondary infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Urmi Roy, Romulo S. de Oliveira, Eric J. C. Galvez, Achim Gronow, Marijana Basic, Laura Garcia Perez, Nicola Gagliani, Andre Bleich, Samuel Huber, Till Strowig
Summary: The study reveals that segmented filamentous bacteria (SFB) not only induce Th17 cells but also distinct IL-17A negative CD4+ T cell populations in the intestine, some of which produce IL-22 upon restimulation and during enteric infections. These cells, presumably Th22 cells, develop independently of intestinal Th17 cells and produce a different set of cytokines compared to Th17 cells. This suggests that aside from Th17, SFB can also induce CD4+ T cell populations that serve as an immediate source of IL-22 during intestinal inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yanyu Zhang, Song Gao, Shifei Yao, Danlin Weng, Yan Wang, Qi Huang, Xuemei Zhang, Hong Wang, Wenchun Xu
Summary: The study found that the SPY1 vaccine increased the expression of IL-27 and its specific receptor (WSX-1), promoting vaccine protection through activation of the STAT3 and NF-κB signaling pathways and production of memory CD4(+)T cells to enhance Th17 cell polarization. Additionally, the immune protection of the vaccine was independent of aerobic glycolysis.
Article
Immunology
Christina Seitz, Anne-Laure Joly, Fang Fang, Katie Frith, Paul Gray, John Andersson
Summary: The transcription factor FOXP3 is crucial for the development and function of CD4(+)FOXP3(+) regulatory T (Treg) cells. Alterations in the expression of FOXP3 isoforms are associated with inflammatory disease progression. This study investigates the effects of a specific FOXP3 mutation on Treg cell subsets. The findings suggest that the full-length FOXP3 isoform is important for maintaining Treg cell lineage stability but not essential for Treg cell activation.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Emil Lagumdzic, Clara Pernold, Marta Viano, Simone Olgiati, Michael W. Schmitt, Kerstin H. Mair, Armin Saalmueller
Summary: Pigs have the potential to be a valuable research model for studying human diseases, pharmacology, and transplantation. This study aimed to better understand the porcine immune system by analyzing the transcriptomes of different subsets of porcine CD8(+) T cells. The results showed distinct gene expression patterns in different subsets, providing valuable information for further research on porcine immune cell subsets.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Biochemical Research Methods
Andrea Olga Papadopoulos, Zaza Mtine Ndhlovu
Summary: With advancements in CRISPR technology, it is now possible to edit the naive CD4(+) T cells in the immune system, improving its overall function.
Article
Cell Biology
Brooks Hopkins, Justin Fisher, Meiping Chang, Xiaoyan Tang, Zhimei Du, William J. Kelly, Zuyi Huang
Summary: This study conducted experiments on the growth of different T cell subsets under different combinations of IL-2, IL-7, and IL-15, developed mathematical models to predict optimal growth conditions, and analyzed RNA sequencing data to study gene networks influencing growth pathways.
Article
Immunology
Shun Tanemoto, Tomohisa Sujino, Kentaro Miyamoto, Jonathan Moody, Yusuke Yoshimatsu, Yoshinari Ando, Ikuko Koya, Yosuke Harada, Anna Okuzawa Tojo, Keiko Ono, Yukie Hayashi, Kaoru Takabayashi, Koji Okabayashi, Toshiaki Teratani, Yohei Mikami, Nobuhiro Nakamoto, Naoki Hosoe, Haruhiko Ogata, Chung-Chau Hon, Jay W. Shin, Takanori Kanai
Summary: This study identified the presence of cytotoxic CD4(+)CD8(+) T cells in the human intestine, with a significantly reduced percentage in patients with inflammatory bowel disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Rui Xu, Ming Wu, Shuna Liu, Wenwen Shang, Rong Li, Juan Xu, Lei Huang, Fang Wang
Summary: Immunotherapy is expected to be a promising treatment for ovarian cancer due to its immunogenicity. However, immunosuppression in the tumor microenvironment poses challenges. Studies have shown that the metabolism pathways of Tregs in the cancer environment may contribute to immunosuppression, and TLR8 can reverse the inhibitory function of Tregs. Activation of TLR8 signaling results in decreased glucose metabolism in Tregs and promotes proliferation of naive T cells in the ovarian cancer microenvironment.
CELL DEATH & DISEASE
(2021)
Article
Biology
George Elias, Pieter Meysman, Esther Bartholomeus, Nicolas De Neuter, Nina Keersmaekers, Arvid Suls, Hilde Jansens, Aisha Souquette, Hans De Reu, Marie-Paule Emonds, Evelien Smits, Eva Lion, Paul G. Thomas, Geert Mortier, Pierre Van Damme, Philippe Beutels, Kris Laukens, Viggo Van Tendeloo, Benson Ogunjimi
Summary: This study demonstrates the significant impact of preexisting memory CD4 T cell clones on vaccine-induced immunity to hepatitis B. The presence of these clones can predict the strength and timing of the immune response to vaccination.
Article
Immunology
Bilade Cherqaoui, Frederic Cremazy, Marc Lauraine, Ghazal Shammas, Roula Said-Nahal, Hendrick Mambu Mambueni, Felicie Costantino, Marine Fourmont, Audrey Hulot, Henri-Jean Garchon, Simon Glatigny, Luiza M. Araujo, Maxime Breban
Summary: The naïve CD4+ T cells of B27-rats exhibit a predisposition towards Th17 differentiation due to a STAT1 deficiency, which occurs early and is associated with an epigenetic Th17 bias. This molecular phenomenon may contribute to the persistent proinflammatory skew of CD4+ T cells in SpA patients, providing new insights for understanding and treating SpA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Don-Marc Franchini, Olivia Lanvin, Marie Tosolini, Emilie Patras de Campaigno, Anne Cammas, Sarah Pericart, Clara-Maria Scarlata, Morgane Lebras, Cedric Rossi, Laetitia Ligat, Frederic Pont, Paola B. Arimondo, Camille Laurent, Maha Ayyoub, Fabien Despas, Maryse Lapeyre-Mestre, Stefania Millevoi, Jean-Jacques Fournie
Article
Oncology
Camille-Charlotte Balanca, Clara-Maria Scarlata, Marie Michelas, Christel Devaud, Victor Sarradin, Camille Franchet, Carlos MartinezGomez, Carlos Gomez-Roca, Marie Tosolini, Diana Heaugwane, Francoise Lauzeral-Vizcaino, Lucile Mir-Mesnier, Virginie Feliu, Carine Valle, Frederic Pont, Gwenael Ferron, Laurence Gladieff, Stephanie Motton, Yann Tanguy Le Gac, Agnes Dupret-Bories, Jerome Sarini, Benjamin Vairel, Claire Illac, Aurore Siegfried-Vergnon, Eliane Mery, Jean-Jacques Fournie, Sebastien Vergez, Jean-Pierre Delord, Philippe Rochaix, Alejandra Martinez, Maha Ayyoub
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Oncology
Melissa Prat, Augustin Le Naour, Kimberley Coulson, Fanny Lemee, Helene Leray, Godefroy Jacquemin, Mouna Chirine Rahabi, Lea Lemaitre, Helene Authier, Gwenael Ferron, Jean-Marc Barret, Alejandra Martinez, Maha Ayyoub, Jean-Pierre Delord, Laurence Gladieff, Isabelle Tabah-Fisch, Jean-Francois Prost, Bettina Couderc, Agnes Coste
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Review
Oncology
Alejandra Martinez, Jean-Pierre Delord, Maha Ayyoub, Christel Devaud
Article
Immunology
Marianne Weulersse, Assia Asrir, Andrea C. Pichler, Lea Lemaitre, Matthias Braun, Nadege Carrie, Marie-Veronique Joubert, Marie Le Moine, Laura Do Souto, Guillaume Gaud, Indrajit Das, Elisa Brauns, Clara M. Scarlata, Elena Morandi, Ashmitha Sundarrajan, Marine Cuisinier, Laure Buisson, Sabrina Maheo, Sahar Kassem, Arantxa Agesta, Michael Peres, Els Verhoeyen, Alejandra Martinez, Julien Mazieres, Loic Dupre, Thomas Gossye, Vera Pancaldi, Camille Guillerey, Maha Ayyoub, Anne S. Dejean, Abdelhadi Saoudi, Stanislas Goriely, Herve Avet-Loiseau, Tobias Bald, Mark J. Smyth, Ludovic Martinet
Article
Oncology
Anne Montfort, Thomas Filleron, Mathieu Virazels, Carine Dufau, Jean Milhes, Cecile Pages, Pascale Olivier, Maha Ayyoub, Muriel Mounier, Amelie Lusque, Stephanie Brayer, Jean-Pierre Delord, Nathalie Andrieu-Abadie, Thierry Levade, Celine Colacios, Bruno Segui, Nicolas Meyer
Summary: TNF blockers can help manage gastrointestinal inflammatory side effects following nivolumab and/or ipilimumab treatment in patients with advanced melanoma, and may enhance the efficacy of immune checkpoint inhibitors. The combination of certolizumab showed a high response rate in patients, warranting further investigation. Both combinations were found to be safe and showed clinical and biological activities in human patients.
CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Camille-Charlotte Balanca, Anna Salvioni, Clara-Maria Scarlata, Marie Michelas, Carlos Martinez-Gomez, Carlos Gomez-Roca, Victor Sarradin, Marie Tosolini, Carine Valle, Frederic Pont, Gwenael Ferron, Laurence Gladieff, Sebastien Vergez, Agnes Dupret-Bories, Eliane Mery, Philippe Rochaix, Jean-Jacques Fournie, Jean-Pierre Delord, Christel Devaud, Alejandra Martinez, Maha Ayyoub
Summary: Tumor antigen-specific CD4 T cells exhibit exhaustion in patients with head and neck, cervical, and ovarian cancer, characterized by high PD-1 and CD39 expression and low cytokine secretion despite functional presence. Terminal exhaustion of CD4 T cells is observed regardless of TIM-3 expression, suggesting divergence from CD8 T cell exhaustion. PD-1 blockade enhances CD4 T cell activation and promotes dendritic cell maturation, leading to improved tumor-specific CD8 T cell proliferation.
Review
Oncology
Jonathan Khalifa, Julien Mazieres, Carlos Gomez-Roca, Maha Ayyoub, Elizabeth Cohen-Jonathan Moyal
Summary: The dual immune effect of radiotherapy includes both immunostimulatory and immunosuppressive effects, which alone are not enough to drive a strong anti-tumor immune response in most cases. Hence, the rationale for combining radiotherapy and immunotherapy has arisen, with ongoing trials to assess this association in oncology. While some trials have shown promising results, questions remain on optimizing the combination of treatment modalities.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Carlos Martinez-Gomez, Marie Michelas, Clara-Maria Scarlata, Anna Salvioni, Carlos Gomez-Roca, Victor Sarradin, Francoise Lauzeral-Vizcaino, Virginie Feliu, Agnes Dupret-Bories, Gwenael Ferron, Jerome Sarini, Christel Devaud, Jean-Pierre Delord, Camille-Charlotte Balanca, Alejandra Martinez, Maha Ayyoub
Summary: This study identified a population of CD4 T cells expressing inhibitory receptors targeted by immunotherapy in the blood of cancer patients. It showed that high proportions of these cells prior to therapy were associated with a response to immunotherapy. The study also found that exhausted CD4 T cells, which contained low proportions of effector cytokine-producing cells, may play a role in clinical responsiveness to immunotherapy.
Article
Immunology
Virginie Feliu, Carlos Gomez-Roca, Marie Michelas, Noemie Thebault, Francoise Lauzeral-Vizcaino, Anna Salvioni, Lise Scandella, Emeline Sarot, Carine Valle, Camille-Charlotte Balanca, Clara-Maria Scarlata, Jean-Pierre Delord, Maha Ayyoub, Christel Devaud
Summary: Despite the high prognostic value of immune infiltrates in colorectal cancer (CRC), metastatic disease remains resistant to immunotherapy by immune checkpoint blockade (ICB). Here, we show, in metastatic CRC preclinical models, that orthotopically implanted primary colon tumors exert a colon-specific antimetastatic effect on distant hepatic lesions. Enterotropic alpha 4 beta 7 integrin-expressing neoantigen-specific CD8 T cells were key components of the antimetastatic effect. Our findings identify a systemic cancer immunosurveillance role for gut-primed tumor-specific alpha 4 beta 7+ CD8 T cells.
SCIENCE IMMUNOLOGY
(2023)
Meeting Abstract
Oncology
Michael R. Paillasse, James Garner, Michael Fitzgerald, Lise Davenne, Pierre-Benoit Ancey, Celine Poussereau-Pomie, Michael Esquerre, Gaelle Badet, Joel Tuyaret, Marie Mandron, Philippe Rochaix, Maha Ayyoub, Clara Maria Scarlata, Christine Menetrier-Caux, Chrsitophe Caux, Philippe Cassier, Jean-Pierre Delord, Carlos Gomez Roca, Pierre Fons
Article
Genetics & Heredity
Frederic Pont, Marie Tosolini, Qing Gao, Marion Perrier, Miguel Madrid-Mencia, Tse Shun Huang, Pierre Neuvial, Maha Ayyoub, Kristopher Nazor, Jean-Jacques Fournie
NAR GENOMICS AND BIOINFORMATICS
(2020)
Article
Multidisciplinary Sciences
Aurelie Fluckiger, Romain Daillere, Mohamed Sassi, Barbara Susanne Sixt, Peng Liu, Friedemann Loos, Corentin Richard, Catherine Rabu, Maryam Tidjani Alou, Anne-Gaelle Goubet, Fabien Lemaitre, Gladys Ferrere, Lisa Derosa, Connie P. M. Duong, Meriem Messaoudene, Andreanne Gagne, Philippe Joubert, Luisa De Sordi, Laurent Debarbieux, Sylvain Simon, Clara-Maria Scarlata, Maha Ayyoub, Belinda Palermo, Francesco Facciolo, Romain Boidot, Richard Wheeler, Ivo Gomperts Boneca, Zsofia Sztupinszki, Krisztian Papp, Istvan Csabai, Edoardo Pasolli, Nicola Segata, Carlos Lopez-Otin, Zoltan Szallasi, Fabrice Andre, Valerio Iebba, Valentin Quiniou, David Klatzmann, Jacques Boukhalil, Saber Khelaifia, Didier Raoult, Laurence Albiges, Bernard Escudier, Alexander Eggermont, Fathia Mami-Chouaib, Paola Nistico, Francois Ghiringhelli, Bertrand Routy, Nathalie Labarriere, Vincent Cattoir, Guido Kroemer, Laurence Zitvogel
Article
Oncology
Giulia Trimaglio, Anne-Francoise Tilkin-Mariame, Virginie Feliu, Francoise Lauzeral-Vizcaino, Marie Tosolini, Carine Valle, Maha Ayyoub, Olivier Neyrolles, Nathalie Vergnolle, Yoann Rombouts, Christel Devaud
Review
Immunology
Caroline Raffin, Linda T. Vo, Jeffrey A. Bluestone
NATURE REVIEWS IMMUNOLOGY
(2020)