Cell Cycle-Dependent Control and Roles of DNA Topoisomerase II

Casein kinase II-dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast

(2019) Norihiko Nakazawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pif1-Family Helicases Support Fork Convergence during DNA Replication Termination in Eukaryotes

(2019) Tom D. Deegan et al.   MOLECULAR CELL

The Impact of the C-Terminal Region on the Interaction of Topoisomerase II Alpha with Mitotic Chromatin

(2019) Melissa Antoniou-Kourounioti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resolution of human ribosomal DNA occurs in anaphase, dependent on tankyrase 1, condensin II, and topoisomerase IIα

(2019) Zharko Daniloski et al.   GENES & DEVELOPMENT

PICH and TOP3A cooperate to induce positive DNA supercoiling

(2019) Anna H. Bizard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitotic Chromosome Mechanics: How Cells Segregate Their Genome

(2019) Paul Batty et al.   TRENDS IN CELL BIOLOGY

The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity

(2018) Andrew B. Fielding et al.   ONCOGENE

A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest

(2018) Katharina Deiss et al.   NUCLEIC ACIDS RESEARCH

The Unresolved Problem of DNA Bridging

(2018) María Fernández-Casañas et al.   Genes

Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint

(2017) Toshiyuki Kozuki et al.   NUCLEIC ACIDS RESEARCH

Metaphase chromosome structure is dynamically maintained by condensin I-directed DNA (de)catenation

(2017) Ewa Piskadlo et al.   eLife

A noncatalytic function of the topoisomerase II CTD in Aurora B recruitment to inner centromeres during mitosis

(2016) Heather Edgerton et al.   JOURNAL OF CELL BIOLOGY

SUMOylation of DNA topoisomerase IIα regulates histone H3 kinase Haspin and H3 phosphorylation in mitosis

(2016) Makoto M. Yoshida et al.   JOURNAL OF CELL BIOLOGY

Physical Proximity of Sister Chromatids Promotes Top2-Dependent Intertwining

(2016) Nicholas Sen et al.   MOLECULAR CELL

Sister chromatid resolution is an intrinsic part of chromosome organization in prophase

(2016) Kota Nagasaka et al.   NATURE CELL BIOLOGY

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

(2016) Kiran Kumar Naidu Guturi et al.   Nature Communications

Selective killing of G2 decatenation checkpoint defective colon cancer cells by catalytic topoisomerase II inhibitor

(2015) Chetan Kumar Jain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

(2015) Ram Madabhushi et al.   CELL

SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin

(2015) Hyunju Ryu et al.   CELL CYCLE

The mechanism of DNA replication termination in vertebrates

(2015) James M. Dewar et al.   NATURE

Aneuploidy and chromosomal instability in cancer: a jackpot to chaos

(2015) Maybelline Giam et al.   Cell Division

PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis

(2015) Christian F. Nielsen et al.   Nature Communications

Condensin Relocalization from Centromeres to Chromosome Arms Promotes Top2 Recruitment during Anaphase

(2015) Joanne Leonard et al.   Cell Reports

The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling

(2015) Veronica Krenn et al.   Frontiers in Oncology

14-3-3 epsilon prevents G2/M transition of fertilized mouse eggs by binding with CDC25B

(2014) Cheng Cui et al.   BMC DEVELOPMENTAL BIOLOGY

TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres

(2014) Martina Stagno d´Alcontres et al.   CELL CYCLE

Chromosome length and perinuclear attachment constrain resolution of DNA intertwines

(2014) Iris Titos et al.   JOURNAL OF CELL BIOLOGY

Topoisomerase IIα in chromosome instability and personalized cancer therapy

(2014) T Chen et al.   ONCOGENE

A Synthetic Lethal Interaction between APC/C and Topoisomerase Poisons Uncovered by Proteomic Screens

(2014) Manuel Eguren et al.   Cell Reports

A novel chromatin tether domain controls topoisomerase IIα dynamics and mitotic chromosome formation

(2013) Andrew B. Lane et al.   JOURNAL OF CELL BIOLOGY

Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally

(2013) M. Yekezare et al.   JOURNAL OF CELL SCIENCE

Defective Decatenation Checkpoint Function Is a Common Feature of Melanoma

(2013) Kelly Brooks et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

BAF complexes facilitate decatenation of DNA by topoisomerase IIα

(2013) Emily C. Dykhuizen et al.   NATURE

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

Condensin aids sister chromatid decatenation by topoisomerase II

(2013) Adrian Charbin et al.   NUCLEIC ACIDS RESEARCH

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα

(2012) Kumiko Samejima et al.   JOURNAL OF CELL BIOLOGY

DNA catenation maintains structure of human metaphase chromosomes

(2012) David L. V. Bauer et al.   NUCLEIC ACIDS RESEARCH

A model for chromosome condensation based on the interplay between condensin and topoisomerase II

(2012) Jonathan Baxter et al.   TRENDS IN GENETICS

Revised genetic requirements for the decatenation G2 checkpoint: The role of ATM

(2011) Jacquelyn J. Bower et al.   CELL CYCLE

Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells

(2011) Ruth E. Gonzalez et al.   CELL CYCLE

Anaphase DNA bridges induced by lack of RecQ5 inDrosophilasyncytial embryos

(2011) Haruna Sakurai et al.   FEBS LETTERS

Cohesin's Concatenation of Sister DNAs Maintains Their Intertwining

(2011) Ana-Maria Farcas et al.   MOLECULAR CELL

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression

(2011) Mahesh Ramamoorthy et al.   NUCLEIC ACIDS RESEARCH

Positive Supercoiling of Mitotic DNA Drives Decatenation by Topoisomerase II in Eukaryotes

(2011) J. Baxter et al.   SCIENCE

Prevention of DNA re-replication in eukaryotic cells

(2011) L. N. Truong et al.   Journal of Molecular Cell Biology

TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

(2010) Jing Ye et al.   CELL

SMC complexes and topoisomerase II work together so that sister chromatids can work apart

(2010) Claudia Tapia-Alveal et al.   CELL CYCLE

Rad9A Is Required for G2Decatenation Checkpoint and to Prevent Endoreduplication in Response to Topoisomerase II Inhibition

(2010) Deborah A. Greer Card et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity

(2010) Hyunju Ryu et al.   JOURNAL OF CELL BIOLOGY

Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division

(2010) L. H.-C. Wang et al.   JOURNAL OF CELL SCIENCE

Replication Termination at Eukaryotic Chromosomes Is Mediated by Top2 and Occurs at Genomic Loci Containing Pausing Elements

(2010) Daniele Fachinetti et al.   MOLECULAR CELL

Topoisomerase IIα maintains genomic stability through decatenation G2 checkpoint signaling

(2010) J J Bower et al.   ONCOGENE

The MCM-Binding Protein ETG1 Aids Sister Chromatid Cohesion Required for Postreplicative Homologous Recombination Repair

(2010) Naoki Takahashi et al.   PLoS Genetics

The decision to enter mitosis: feedback and redundancy in the mitotic entry network

(2009) Arne Lindqvist et al.   JOURNAL OF CELL BIOLOGY

Conjugation of Human Topoisomerase 2  with Small Ubiquitin-like Modifiers 2/3 in Response to Topoisomerase Inhibitors: Cell Cycle Stage and Chromosome Domain Specificity

(2008) M. Agostinho et al.   CANCER RESEARCH

Resolution of Sister Centromeres Requires RanBP2-Mediated SUMOylation of Topoisomerase IIα

(2008) Meelad M. Dawlaty et al.   CELL

Condensin-Dependent rDNA Decatenation Introduces a Temporal Pattern to Chromosome Segregation

(2008) Claudio D'Ambrosio et al.   CURRENT BIOLOGY

Loss of RecQ5 leads to spontaneous mitotic defects and chromosomal aberrations in Drosophila melanogaster

(2008) Minoru Nakayama et al.   DNA REPAIR

A topoisomerase II-dependent mechanism for resetting replicons at the S-M-phase transition

(2008) O. Cuvier et al.   GENES & DEVELOPMENT

Plk1-dependent Phosphorylation Regulates Functions of DNA Topoisomerase IIα in Cell Cycle Progression

(2008) Hongchang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Topoisomerase II Inactivation Prevents the Completion of DNA Replication in Budding Yeast

(2008) Jonathan Baxter et al.   MOLECULAR CELL

Topoisomerase IIα controls the decatenation checkpoint

(2008) Kuntian Luo et al.   NATURE CELL BIOLOGY

Casein kinase I  /  phosphorylates topoisomerase II  at serine-1106 and modulates DNA cleavage activity

(2008) A. G. Grozav et al.   NUCLEIC ACIDS RESEARCH