Review
Biochemistry & Molecular Biology
Marco A. Andonegui-Elguera, Rodrigo E. Caceres-Gutierrez, Alejandro Lopez-Saavedra, Fernanda Cisneros-Soberanis, Montserrat Justo-Garrido, Jose Diaz-Chavez, Luis A. Herrera
Summary: During mitosis, chromatin undergoes various activities regulated by histone post-translational modifications (HPTMs). Specific HPTMs play roles in chromosome condensation, centromere formation, and the assembly of regulatory protein complexes. Additionally, environmental factors can modify HPTMs, affecting chromosome segregation and genome stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Yuting Liu, Kehui Wang, Li Huang, Jicheng Zhao, Xinpeng Chen, Qiang Wu, Zhouliang Yu, Guohong Li
Summary: The phosphorylation of CENP-A Ser68 is crucial for the cell-cycle-dependent deposition of CENP-A and cell viability.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Cell Biology
Conor P. Herlihy, Sabine Hahn, Nicole M. Hermance, Elizabeth A. Crowley, Amity L. Manning
Summary: Epigenetic modifications of histones at centromeres and pericentromeric chromatin are crucial for centromere structure and function. Increased localization of Suv39 and Suv420 at centromeres suppresses transcription, compromises Aurora B localization, and leads to errors in chromosome alignment and segregation.
JOURNAL OF CELL SCIENCE
(2021)
Article
Plant Sciences
Yang Liu, Chunhui Wang, Handong Su, James A. Birchler, Fangpu Han
Summary: Haspin regulates chromosomal localization and segregation in both human and plant cells through H3T3 phosphorylation, with slightly different roles observed in mitosis and meiosis in plants. Plant Haspin lacks motifs necessary for binding to specific proteins involved in cohesion, leading to distinct mechanisms of action compared to animals.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Cell Biology
Shreyas Sridhar, Tatsuo Fukagawa
Summary: The assembly of functional kinetochore is crucial for accurate chromosome segregation during mitosis. Internal and external structures of kinetochore face multiple challenges, but linker proteins play an important role in force propagation and recruitment of outer kinetochore. Understanding these linkages and regulatory pathways is essential for understanding kinetochore structural diversity and plasticity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Celia R. Bloom, Brian J. North
Summary: BubR1 plays a crucial role in mitosis and its post-translational modifications are important for its function, which may be associated with pathological conditions.
CELL AND BIOSCIENCE
(2021)
Review
Oncology
Ana Gonzalez-Garcia, Antonio Garrido, Ana C. Carrera
Summary: Genetic alterations in the PI3-kinase/PTEN pathway are common in cancer cells. Current efforts to treat PTEN-dependent tumors mainly focus on PI3-kinase inhibition, but modulating PTEN post-translational modifications could provide alternative therapeutic strategies.
Article
Biochemistry & Molecular Biology
Yujue Chen, Qian Zhang, Hong Liu
Summary: Non-coding centromeres, highly divergent in DNA sequences across species, are actively transcribed by RNAP II, facilitating CENP-A deposition and maintaining centromeric cohesion during mitosis. The regulation of centromeric transcription appears to be unique, as some traditional transcription initiation factors may not be required. This review discusses the novel role and regulation of centromeric transcription, as well as potential underlying mechanisms.
Article
Cell Biology
Xue Bessie Su, Menglu Wang, Claudia Schaffner, Olga O. Nerusheva, Dean Clift, Christos Spanos, David A. Kelly, Michael Tatham, Andreas Wallek, Yehui Wu, Juri Rappsilber, A. Arockia Jeyaprakash, Zuzana Storchova, Ronald T. Hay, Adele L. Marston
Summary: During cell mitosis, SUMOylation plays a critical role in modulating error correction mechanisms by regulating protein interactions, leading to stable sister kinetochore biorientation and timely anaphase onset.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Genetics & Heredity
Andrew D. McAinsh, Adele L. Marston
Summary: This paper presents the components, assembly, structure, and function of kinetochores. The authors outline a blueprint for kinetochore assembly and discuss how functions are mapped onto this architecture. They also explore how the underlying chromatin influences kinetochore shape.
ANNUAL REVIEW OF GENETICS
(2022)
Review
Veterinary Sciences
Tong Zhou, Mingshu Wang, Anchun Cheng, Qiao Yang, Bin Tian, Ying Wu, Renyong Jia, Shun Chen, Mafeng Liu, Xin-Xin Zhao, Xuming Ou, Sai Mao, Di Sun, Shaqiu Zhang, Dekang Zhu, Juan Huang, Qun Gao, Yanling Yu, Ling Zhang
Summary: This article mainly describes the viral protein kinases and their mechanisms of regulating viral protein function through phosphorylation. The study of post-translational modification of viral proteins is of great significance for understanding viral infection mechanisms and developing antiviral treatment.
VETERINARY RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Yun Li, Hong Yang, Tianhan He, Liang Zhang, Chao Liu
Summary: Cav1.2 plays a crucial role in neurodegenerative diseases, but the regulation of its activity remains incompletely understood. The repurposing of DHP drugs may offer potential therapeutic strategies, but further research is needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Juan Facundo Chrestia, Ornella Turani, Noelia Rodriguez Araujo, Guillermina Hernando, Maria del Carmen Esandi, Cecilia Bouzat
Summary: Nicotinic acetylcholine receptors (nAChRs) are widely distributed in the central and peripheral nervous system and play crucial roles in vital physiological processes. Post-translational modifications (PTMs) have been shown to regulate different aspects of nAChR life cycle, but our knowledge in this field is still limited and many important aspects remain unknown.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Rajan Iyyappan, Daria Aleshkina, Hao Ming, Michal Dvoran, Kianoush Kakavand, Denisa Jansova, Edgar del Llano, Lenka Gahurova, Alexander W. Bruce, Tomas Masek, Martin Pospisek, Filip Horvat, Michal Kubelka, Zongliang Jiang, Andrej Susor
Summary: The study reveals a highly dynamic and oscillatory pattern of translational reprogramming in oocytes and early embryos, which is crucial for their developmental competence.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Isabel M. Martin, Camilo Aponte-Santamaria, Lisa Schmidt, Marius Hedtfeld, Adel Iusupov, Andrea Musacchio, Frauke Graeter
Summary: The central intrinsically disordered region (IDR) of the inner centromere protein (INCENP) undergoes conformational changes upon phosphorylation, leading to expansion of the IDR. The transition between globule and coil conformations of the IDR is non-monotonic and dependent on the degree of phosphorylation. Phosphorylation regulates the cohesiveness and phase behavior of INCENP IDR assemblies, influencing the function of INCENP in chromosome segregation.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Walter E. Mills, Jennifer M. Spence, Tatsuo Fukagawa, Christine J. Farr
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Genetics & Heredity
Viryinie Faure, Thomas Wenner, Carol Cooley, Emer Bourke, Christine J. Farr, Shunichi Takeda, Ciaran G. Morrison
Article
Cell Biology
Kumiko Samejima, Itaru Samejima, Paola Vagnarelli, Hiromi Ogawa, Giulia Vargiu, David A. Kelly, Flavia de Lima Alves, Alastair Kerr, Lydia C. Green, Damien F. Hudson, Shinya Ohta, Carol A. Cooke, Christine J. Farr, Juri Rappsilber, William C. Earnshaw
JOURNAL OF CELL BIOLOGY
(2012)
Article
Cell Biology
Carol Cooley, Katie M. Baird, Virginie Faure, Thomas Wenner, Jillian L. Stewart, Sonie Modino, Predrag Slijepcevic, Christine J. Farr, Ciaran G. Morrison
MOLECULAR BIOLOGY OF THE CELL
(2009)
Article
Cell Biology
Susana A. Ribeiro, Jesse C. Gatlin, Yimin Dong, Ajit Joglekar, Lisa Cameron, Damien F. Hudson, Christine J. Farr, Bruce F. McEwen, Edward D. Salmon, William C. Earnshaw, Paola Vagnarelli
MOLECULAR BIOLOGY OF THE CELL
(2009)
Article
Genetics & Heredity
Christopher C. Park, Sangtae Ahn, Joshua S. Bloom, Andy Lin, Richard T. Wang, Tongtong Wu, Aswin Sekar, Arshad H. Khan, Christine J. Farr, Aldons J. Lusis, Richard M. Leahy, Kenneth Lange, Desmond J. Smith
Article
Biochemistry & Molecular Biology
Mark Johnson, Hui Hui Phua, Sophia C. Bennett, Jennifer M. Spence, Christine J. Farr
NUCLEIC ACIDS RESEARCH
(2009)
Article
Biochemistry & Molecular Biology
Christine J. Farr, Melissa Antoniou-Kourounioti, Michael L. Mimmack, Arsen Volkov, Andrew C. G. Porter
NUCLEIC ACIDS RESEARCH
(2014)
Article
Multidisciplinary Sciences
Brankica Mravinac, Lori L. Sullivan, Jason W. Reeves, Christopher M. Yan, Kristen S. Kopf, Christine J. Farr, Mary G. Schueler, Beth A. Sullivan
Review
Endocrinology & Metabolism
David J. Easty, Christine J. Farr, Bryan T. Hennessy
Summary: Vitamin D is a powerful steroid hormone that has widespread effects on gene expression and biological pathways, but its utility as a therapeutic agent is limited by hypercalcemic effects. Vitamin D superagonists show promise in treatment, but require agonists with high cell-tissue specificity to be successful.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Jennifer M. Spence, Hui Hui Phua, Walter Mills, Adam J. Carpenter, Andrew C. G. Porter, Christine J. Farr
JOURNAL OF CELL SCIENCE
(2007)
Article
Cell Biology
Paola Vagnarelli, Damien F. Hudson, Susana A. Ribeiro, Laura Trinkle-Mulcahy, Jennifer M. Spence, Fan Lai, Christine J. Farr, Angus I. Lamond, William C. Earnshaw
NATURE CELL BIOLOGY
(2006)