Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology

TM6SF2: A novel target for plasma lipid regulation

(2018) Ting-Ting Li et al.   ATHEROSCLEROSIS

Multitrait Genome-Wide Association Analysis of Macronutrient Intake Identifies 12 Novel Loci for Dietary Intake and Unravels Genetic Overlap with Lifestyle Traits and Cardiometabolic Diseases

(2018) HASSAN S. DASHTI et al.   DIABETES

Genetic variants in CYP7A1 and risk of myocardial infarction and symptomatic gallstone disease

(2018) Faiza Qayyum et al.   EUROPEAN HEART JOURNAL

Fibrosis Severity as a Determinant of Cause-Specific Mortality in Patients With Advanced Nonalcoholic Fatty Liver Disease

(2018) Eduardo Vilar-Gomez et al.   GASTROENTEROLOGY

Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD

(2018) Cyrielle Caussy et al.   HEPATOLOGY

ADAPT: An algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis

(2018) Samuel J. Daniels et al.   HEPATOLOGY

Genetic and functional analysis of FGF21 in NAFLD/NASH

(2018) R. Gallego-Durán et al.   JOURNAL OF HEPATOLOGY

The PNPLA3 SNP rs738409:G allele is associated with increased liver disease-associated mortality but reduced overall mortality in a population-based cohort

(2018) Peter J. Meffert et al.   JOURNAL OF HEPATOLOGY

Genetics and epigenetics of NAFLD and NASH: Clinical impact

(2018) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030

(2018) Chris Estes et al.   JOURNAL OF HEPATOLOGY

Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence?

(2018) Amedeo Lonardo et al.   JOURNAL OF HEPATOLOGY

How CRISPR is transforming drug discovery

(2018) Andrew Scott   NATURE

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

(2018) Masahiro Kanai et al.   NATURE GENETICS

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

(2018) Anubha Mahajan et al.   NATURE GENETICS

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

(2018) Lesley Hoyles et al.   NATURE MEDICINE

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease

(2018) Noura S. Abul-Husn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

(2018) Viktoria Gusarova et al.   Nature Communications

A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure

(2018) Timothy M. Frayling et al.   Cell Reports

Genes that make you fat, but keep you healthy

(2018) Ruth J.F. Loos et al.   JOURNAL OF INTERNAL MEDICINE

Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis

(2018) Miriam S. Udler et al.   PLOS MEDICINE

Worldwide trends in insufficient physical activity from 2001 to 2016: a pooled analysis of 358 population-based surveys with 1·9 million participants

(2018) Regina Guthold et al.   Lancet Global Health

The Role of PCSK9 in the Pathogenesis of Non-alcoholic Fatty Liver Disease and the Effect of PCSK9 Inhibitors

(2018) Eleni Theocharidou et al.   CURRENT PHARMACEUTICAL DESIGN

Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension

(2018) Yingjie Ji et al.   DIABETES

HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease

(2018) Yanling Ma et al.   HEPATOLOGY

A polymorphism in the Irisin-encoding gene (FNDC5) associates with hepatic steatosis by differential miRNA binding to the 3′UTR

(2018) Mayada Metwally et al.   JOURNAL OF HEPATOLOGY

Beyond fat accumulation, NAFLD genetics converges on lipid droplet biology

(2018) Guido Baselli et al.   JOURNAL OF LIPID RESEARCH

Target-Specific Precision of CRISPR-Mediated Genome Editing

(2018) Anob M. Chakrabarti et al.   MOLECULAR CELL

Altered hepatic genes related to retinol metabolism and plasma retinol in patients with non-alcoholic fatty liver disease

(2018) Paulina Pettinelli et al.   PLoS One

Phenome-wide association studies across large population cohorts support drug target validation

(2018) Dorothée Diogo et al.   Nature Communications

Liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease: Mendelian randomization and meta-analysis of 279 013 individuals

(2017) Bo Kobberø Lauridsen et al.   EUROPEAN HEART JOURNAL

PNPLA3, TM6SF2, and MBOAT7 Genotypes and Coronary Artery Disease

(2017) Nynke Simons et al.   GASTROENTEROLOGY

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells

(2017) Francesca Virginia Bruschi et al.   HEPATOLOGY

Interferon lambda 4 rs368234815 TT>δG variant is associated with liver damage in patients with nonalcoholic fatty liver disease

(2017) Salvatore Petta et al.   HEPATOLOGY

The membrane-bound O-acyltransferase domain-containing 7 variant rs641738 increases inflammation and fibrosis in chronic hepatitis B

(2017) Khaled Thabet et al.   HEPATOLOGY

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

The ubiquity of pleiotropy in human disease

(2017) Kevin Chesmore et al.   HUMAN GENETICS

MERTK rs4374383 variant predicts incident nonalcoholic fatty liver disease and diabetes: role of mononuclear cell activation and adipokine response to dietary fat

(2017) Giovanni Musso et al.   HUMAN MOLECULAR GENETICS

Elevated Liver Enzymes and Mortality in Older Individuals

(2017) Suzanne E. Mahady et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis

(2017) Cyrielle Caussy et al.   JOURNAL OF CLINICAL INVESTIGATION

BMS-986036 (pegylated FGF21) in patients with non-alcoholic steatohepatitis: a phase 2 study

(2017) A. Sanyal et al.   JOURNAL OF HEPATOLOGY

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

(2017) P. Dongiovanni et al.   JOURNAL OF INTERNAL MEDICINE

Network analyses identify liver‐specific targets for treating liver diseases

(2017) Sunjae Lee et al.   Molecular Systems Biology

IFN-λ3, not IFN-λ4, likely mediates IFNL3–IFNL4 haplotype–dependent hepatic inflammation and fibrosis

(2017) Mohammed Eslam et al.   NATURE GENETICS

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci

(2017) Stefan Stender et al.   NATURE GENETICS

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

(2017) Brian D Hobbs et al.   NATURE GENETICS

Exome-wide association study of plasma lipids in >300,000 individuals

(2017) Dajiang J Liu et al.   NATURE GENETICS

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Genetic architecture: the shape of the genetic contribution to human traits and disease

(2017) Nicholas J. Timpson et al.   NATURE REVIEWS GENETICS

Human genetic variation and the gut microbiome in disease

(2017) Andrew Brantley Hall et al.   NATURE REVIEWS GENETICS

Genetic determination of body fat distribution and the attributive influence on metabolism

(2017) Ellen Fehlert et al.   Obesity

Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level1,2

(2016) Silvia Sookoian et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Liver fat accumulation is associated with circulating PCSK9

(2016) Massimiliano Ruscica et al.   ANNALS OF MEDICINE

Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease

(2016) Hanieh Yaghootkar et al.   DIABETES

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Than Transient Elastography

(2016) Kento Imajo et al.   GASTROENTEROLOGY

Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study

(2016) Jeffrey Cui et al.   HEPATOLOGY

Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes

(2016) Mohammed Eslam et al.   HEPATOLOGY

FibroGENE: A gene-based model for staging liver fibrosis

(2016) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

MERTK rs4374383 polymorphism affects the severity of fibrosis in non-alcoholic fatty liver disease

(2016) Salvatore Petta et al.   JOURNAL OF HEPATOLOGY

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

(2016) Luca A Lotta et al.   NATURE GENETICS

A plethora of pleiotropy across complex traits

(2016) Peter M Visscher et al.   NATURE GENETICS

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

(2016) Jun Wang et al.   NATURE GENETICS

The effect of host genetics on the gut microbiome

(2016) Marc Jan Bonder et al.   NATURE GENETICS

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

The implications of the shared genetics of psychiatric disorders

(2016) Michael C O'Donovan et al.   NATURE MEDICINE

The role of the gut microbiota in NAFLD

(2016) Christopher Leung et al.   Nature Reviews Gastroenterology & Hepatology

MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C

(2016) Khaled Thabet et al.   Nature Communications

Does Metabolically Healthy Obesity Exist?

(2016) Araceli Muñoz-Garach et al.   Nutrients

Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes

(2015) Tove Fall et al.   DIABETES

A systematic review of the prevalence of mildly abnormal liver function tests and associated health outcomes

(2015) Sven Radcke et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study

(2015) Rohit Loomba et al.   GASTROENTEROLOGY

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

(2015) Robert J. Wong et al.   GASTROENTEROLOGY

Transmembrane 6 superfamily member 2 gene E167K variant impacts on steatosis and liver damage in chronic hepatitis C patients

(2015) Marta Milano et al.   HEPATOLOGY

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

(2015) Paola Dongiovanni et al.   HEPATOLOGY

Genetic and epigenetic mechanisms of NASH

(2015) Mohammed Eslam et al.   Hepatology International

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

(2015) Daniel I Swerdlow et al.   LANCET

New genetic loci link adipose and insulin biology to body fat distribution

(2015) Dmitry Shungin et al.   NATURE

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

(2015) Stephan Buch et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of type 2 diabetes subgroups through topological analysis of patient similarity

(2015) Li Li et al.   Science Translational Medicine

Genome-Wide Association Studies and Hepatitis C: Harvesting the Benefits of the Genomic Revolution

(2015) Mohammed Eslam et al.   SEMINARS IN LIVER DISEASE

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

(2015) Mohammed Eslam et al.   Nature Communications

Pleiotropic Effects of Lipid Genes on Plasma Glucose, HbA1c, and HOMA-IR Levels

(2014) N. Li et al.   DIABETES

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

(2014) Carlo Pirazzi et al.   HUMAN MOLECULAR GENETICS

Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma

(2014) Y.-L. Liu et al.   JOURNAL OF HEPATOLOGY

The Single Nucleotide Polymorphism rs499765 Is Associated with Fibroblast Growth Factor 21 and Nonalcoholic Fatty Liver Disease in a Chinese Population with Normal Glucose Tolerance

(2014) Shan Jiang et al.   Journal of Nutrigenetics and Nutrigenomics

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

(2014) Oddgeir L Holmen et al.   NATURE GENETICS

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content

(2014) H. Mahdessian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B

(2013) Mauro Viganò et al.   HEPATOLOGY

Characterization of european ancestry nonalcoholic fatty liver disease-associated variants in individuals of african and hispanic descent

(2013) Nicholette D. Palmer et al.   HEPATOLOGY

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

Body Fat Distribution and Risk of Cardiovascular Disease

(2012) Jean-Pierre Després   CIRCULATION

Genome-Wide Association Study Identifies Variants Associated With Progression of Liver Fibrosis From HCV Infection

(2012) Etienne Patin et al.   GASTROENTEROLOGY

Unraveling the genetics of fatty liver in obese children: Additive effect of P446L GCKR and I148M PNPLA3 polymorphisms

(2012) Luca Valenti et al.   HEPATOLOGY

Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis

(2012) Rohit Loomba et al.   HEPATOLOGY

Immune-mediated disease genetics: the shared basis of pathogenesis

(2012) Chris Cotsapas et al.   TRENDS IN IMMUNOLOGY

Effect of genetic and environmental influences on cardiometabolic risk factors: a twin study

(2011) György Jermendy et al.   Cardiovascular Diabetology

Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance

(2011) N. Maneka G. De Silva et al.   DIABETES

Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study

(2011) P. Almgren et al.   DIABETOLOGIA

China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up

(2011) Z. Chen et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy

(2011) David Preiss   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Use of A Mendelian Randomization Approach to Assess the Causal Relation of  -Glutamyltransferase with Blood Pressure and Serum Insulin Levels

(2010) D. Conen et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Genetic Covariance Between γ-Glutamyl Transpeptidase and Fatty Liver Risk Factors: Role of β2-Adrenergic Receptor Genetic Variation in Twins

(2010) Rohit Loomba et al.   GASTROENTEROLOGY

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

Fatty liver disease: the hepatic manifestation of metabolic syndrome

(2010) Amalia Gastaldelli   HYPERTENSION RESEARCH

A position statement on NAFLD/NASH based on the EASL 2009 special conference

(2010) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

Missing heritability and strategies for finding the underlying causes of complex disease

(2010) Evan E. Eichler et al.   NATURE REVIEWS GENETICS

Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease

(2010) Giovanni Targher et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Prevalence of Metabolically Healthy Obese Subjects Defined by BMI and Dual-Energy X-Ray Absorptiometry

(2010) Jennifer L. Shea et al.   Obesity

Molecular basis of trait correlations

(2010) Yongsheng Chen et al.   TRENDS IN PLANT SCIENCE

Shadows of complexity: what biological networks reveal about epistasis and pleiotropy

(2009) Anna L. Tyler et al.   BIOESSAYS

Heritability of Nonalcoholic Fatty Liver Disease

(2009) Jeffrey B. Schwimmer et al.   GASTROENTEROLOGY

Decreased survival of subjects with elevated liver function tests during a 28-year follow-up

(2009) Cecilia Söderberg et al.   HEPATOLOGY

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

(2009) Silvia Sookoian et al.   JOURNAL OF LIPID RESEARCH

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Fatty Liver

(2007) Anna Kotronen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY