Genetic architecture: the shape of the genetic contribution to human traits and disease
出版年份 2017 全文链接
标题
Genetic architecture: the shape of the genetic contribution to human traits and disease
作者
关键词
-
出版物
NATURE REVIEWS GENETICS
Volume 19, Issue 2, Pages 110-124
出版商
Springer Nature
发表日期
2017-12-11
DOI
10.1038/nrg.2017.101
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants
- (2017) Stephen Burgess et al. EPIDEMIOLOGY
- Rare and low-frequency coding variants alter human adult height
- (2017) Eirini Marouli et al. NATURE
- Genetic effects on gene expression across human tissues
- (2017) François Aguet et al. NATURE
- Genotype–covariate interaction effects and the heritability of adult body mass index
- (2017) Matthew R Robinson et al. NATURE GENETICS
- Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
- (2017) John P Kemp et al. NATURE GENETICS
- Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
- (2017) Zhiqiang Li et al. NATURE GENETICS
- Mendelian randomization in cardiometabolic disease: challenges in evaluating causality
- (2017) Michael V. Holmes et al. Nature Reviews Cardiology
- Selection against variants in the genome associated with educational attainment
- (2017) Augustine Kong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The impact of migration on tuberculosis epidemiology and control in high-income countries: a review
- (2016) Manish Pareek et al. BMC Medicine
- The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
- (2016) William J. Astle et al. CELL
- Toward Precision Medicine: TBC1D4 Disruption Is Common Among the Inuit and Leads to Underdiagnosis of Type 2 Diabetes
- (2016) Despoina Manousaki et al. DIABETES CARE
- The genetic architecture of type 2 diabetes
- (2016) Christian Fuchsberger et al. NATURE
- Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps
- (2016) Valentina Iotchkova et al. NATURE GENETICS
- Physical and neurobehavioral determinants of reproductive onset and success
- (2016) Felix R Day et al. NATURE GENETICS
- A reference panel of 64,976 haplotypes for genotype imputation
- (2016) NATURE GENETICS
- Detection of human adaptation during the past 2000 years
- (2016) Yair Field et al. SCIENCE
- Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
- (2015) J. Bowden et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both
- (2015) Brian A. Ference et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture
- (2015) Hou‐Feng Zheng et al. NATURE
- Population genetic differentiation of height and body mass index across Europe
- (2015) Matthew R Robinson et al. NATURE GENETICS
- Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers
- (2015) Carlo Sidore et al. NATURE GENETICS
- The support of human genetic evidence for approved drug indications
- (2015) Matthew R Nelson et al. NATURE GENETICS
- Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index
- (2015) Jian Yang et al. NATURE GENETICS
- Large-scale whole-genome sequencing of the Icelandic population
- (2015) Daniel F Gudbjartsson et al. NATURE GENETICS
- LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
- (2015) Brendan K Bulik-Sullivan et al. NATURE GENETICS
- A copy number variation map of the human genome
- (2015) Mehdi Zarrei et al. NATURE REVIEWS GENETICS
- Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia
- (2015) Daniel Gaudet et al. NEW ENGLAND JOURNAL OF MEDICINE
- An update on the genetic architecture of hyperuricemia and gout
- (2015) Tony R Merriman ARTHRITIS RESEARCH & THERAPY
- The Power of Gene-Based Rare Variant Methods to Detect Disease-Associated Variation and Test Hypotheses About Complex Disease
- (2015) Loukas Moutsianas et al. PLoS Genetics
- Estimating Genome-Wide Significance for Whole-Genome Sequencing Studies
- (2014) ChangJiang Xu et al. GENETIC EPIDEMIOLOGY
- Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
- (2014) Ron Do et al. NATURE
- A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
- (2014) Ida Moltke et al. NATURE
- Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31
- (2014) Unnur Styrkarsdottir et al. NATURE GENETICS
- Defining the role of common variation in the genomic and biological architecture of adult human height
- (2014) Andrew R Wood et al. NATURE GENETICS
- Large-scale genomics unveils the genetic architecture of psychiatric disorders
- (2014) Jacob Gratten et al. NATURE NEUROSCIENCE
- The contribution of genetic variants to disease depends on the ruler
- (2014) John S. Witte et al. NATURE REVIEWS GENETICS
- Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease
- (2014) Anders Berg Jørgensen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- UK Biobank Data: Come and Get It
- (2014) N. E. Allen et al. Science Translational Medicine
- Epidemiological studies of migration and environmental risk factors in the inflammatory bowel diseases
- (2014) Yanna Ko WORLD JOURNAL OF GASTROENTEROLOGY
- A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans
- (2014) Nicholas J. Timpson et al. Nature Communications
- Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants
- (2014) Kalliope Panoutsopoulou et al. Nature Communications
- A Population Genetic Signal of Polygenic Adaptation
- (2014) Jeremy J. Berg et al. PLoS Genetics
- Acculturation and obesity among migrant populations in high income countries – a systematic review
- (2013) Maryam Delavari et al. BMC PUBLIC HEALTH
- Empirical power of very rare variants for common traits and disease: results from sanger sequencing 1998 individuals
- (2013) Martin Ladouceur et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits
- (2013) Unnur Styrkarsdottir et al. NATURE
- Discovery and refinement of loci associated with lipid levels
- (2013) Cristen J Willer et al. NATURE GENETICS
- Validating therapeutic targets through human genetics
- (2013) Robert M. Plenge et al. NATURE REVIEWS DRUG DISCOVERY
- The heritability of human disease: estimation, uses and abuses
- (2013) Albert Tenesa et al. NATURE REVIEWS GENETICS
- Pleiotropy in complex traits: challenges and strategies
- (2013) Nadia Solovieff et al. NATURE REVIEWS GENETICS
- Pitfalls of predicting complex traits from SNPs
- (2013) Naomi R. Wray et al. NATURE REVIEWS GENETICS
- The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
- (2013) Danielle Welter et al. NUCLEIC ACIDS RESEARCH
- GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
- (2013) C. A. Rietveld et al. SCIENCE
- All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs
- (2013) Andrew J. Schork et al. PLoS Genetics
- Five Years of GWAS Discovery
- (2012) Peter M. Visscher et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Effect of a Monoclonal Antibody to PCSK9 on Low-Density Lipoprotein Cholesterol Levels in Statin-Intolerant Patients
- (2012) David Sullivan et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Evidence of widespread selection on standing variation in Europe at height-associated SNPs
- (2012) Michael C Turchin et al. NATURE GENETICS
- Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
- (2012) Karol Estrada et al. NATURE GENETICS
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- (2012) NATURE GENETICS
- Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
- (2012) Robert A Scott et al. NATURE GENETICS
- Erratum: Genetics of osteoporosis from genome-wide association studies: advances and challenges
- (2012) J. Brent Richards et al. NATURE REVIEWS GENETICS
- Regulation of glucose transport by insulin: traffic control of GLUT4
- (2012) Dara Leto et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The Empirical Power of Rare Variant Association Methods: Results from Sanger Sequencing in 1,998 Individuals
- (2012) Martin Ladouceur et al. PLoS Genetics
- WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk
- (2012) Hou-Feng Zheng et al. PLoS Genetics
- Antagonistic pleiotropy as a widespread mechanism for the maintenance of polymorphic disease alleles
- (2011) Ashley JR Carter et al. BMC Medical Genetics
- Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels
- (2011) Abbas Dehghan et al. CIRCULATION
- Comparison of statistical tests for disease association with rare variants
- (2011) Saonli Basu et al. GENETIC EPIDEMIOLOGY
- Performance comparison of exome DNA sequencing technologies
- (2011) Michael J Clark et al. NATURE BIOTECHNOLOGY
- Phase III and submission failures: 2007–2010
- (2011) John Arrowsmith NATURE REVIEWS DRUG DISCOVERY
- Understanding type 1 diabetes through genetics: advances and prospects
- (2011) Constantin Polychronakos et al. NATURE REVIEWS GENETICS
- Repetitive DNA and next-generation sequencing: computational challenges and solutions
- (2011) Todd J. Treangen et al. NATURE REVIEWS GENETICS
- Genome structural variation discovery and genotyping
- (2011) Can Alkan et al. NATURE REVIEWS GENETICS
- Interpretation and use of FRAX in clinical practice
- (2011) J. A. Kanis et al. OSTEOPOROSIS INTERNATIONAL
- Evolution of lactase persistence: an example of human niche construction
- (2011) P. Gerbault et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Synthetic Associations Created by Rare Variants Do Not Explain Most GWAS Results
- (2011) Naomi R. Wray et al. PLOS BIOLOGY
- Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals
- (2011) Carl A. Anderson et al. PLOS BIOLOGY
- A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci
- (2011) Jonathan P. Bradfield et al. PLoS Genetics
- The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: A study of postmenopausal twins
- (2010) N.K. Arden et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
- (2010) The Emerging Risk Factors Collaboration LANCET
- Common genetic determinants of vitamin D insufficiency: a genome-wide association study
- (2010) Thomas J Wang et al. LANCET
- Statistical analysis strategies for association studies involving rare variants
- (2010) Vikas Bansal et al. NATURE REVIEWS GENETICS
- How culture shaped the human genome: bringing genetics and the human sciences together
- (2010) Kevin N. Laland et al. NATURE REVIEWS GENETICS
- Rare Variants Create Synthetic Genome-Wide Associations
- (2010) Samuel P. Dickson et al. PLOS BIOLOGY
- Emerging Treatments in Cystic Fibrosis
- (2009) Andrew M. Jones et al. DRUGS
- Human genetic variation and its contribution to complex traits
- (2009) Kelly A. Frazer et al. NATURE REVIEWS GENETICS
- Decanalization and the origin of complex disease
- (2009) Greg Gibson NATURE REVIEWS GENETICS
- Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
- (2009) L. A. Hindorff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes
- (2009) David G. Clayton PLoS Genetics
- Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae
- (2009) Jennifer K. Lowe et al. PLoS Genetics
- Designing Genome-Wide Association Studies: Sample Size, Power, Imputation, and the Choice of Genotyping Chip
- (2009) Chris C. A. Spencer et al. PLoS Genetics
- Identification of loci associated with schizophrenia by genome-wide association and follow-up
- (2008) Michael C O'Donovan et al. NATURE GENETICS
- Common variants at 30 loci contribute to polygenic dyslipidemia
- (2008) Sekar Kathiresan et al. NATURE GENETICS
- Common and rare variants in multifactorial susceptibility to common diseases
- (2008) Walter Bodmer et al. NATURE GENETICS
- Newly identified loci that influence lipid concentrations and risk of coronary artery disease
- (2008) Cristen J Willer et al. NATURE GENETICS
- Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
- (2008) Sekar Kathiresan et al. NATURE GENETICS
- Heritability in the genomics era — concepts and misconceptions
- (2008) Peter M. Visscher et al. NATURE REVIEWS GENETICS
- Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation
- (2008) J. Z. Li et al. SCIENCE
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