Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level1,2

Liver enzymes, metabolomics and genome-wide association studies: From systems biology to the personalized medicine

(2015) Silvia Sookoian et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Activating transcription factor 4 mediates up-regulation of alanine aminotransferase 2 gene expression under metabolic stress

(2014) María C. Salgado et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease

(2014) Maryann Maximos et al.   HEPATOLOGY

Metabolic make-up of NASH: from fat and sugar to amino acids

(2014) Silvia Sookoian et al.   Nature Reviews Gastroenterology & Hepatology

Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD

(2013) Amedeo Lonardo et al.   CURRENT PHARMACEUTICAL DESIGN

Association Between High-Normal Levels of Alanine Aminotransferase and Risk Factors for Atherogenesis

(2013) M. Shadab Siddiqui et al.   GASTROENTEROLOGY

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Obstructive Sleep Apnea Is Associated with Fatty Liver and Abnormal Liver Enzymes: a Meta-analysis

(2013) Silvia Sookoian et al.   OBESITY SURGERY

Aminotransferase Levels Are Associated With Cardiometabolic Risk Above and Beyond Visceral Fat and Insulin Resistance

(2012) Stacy A. Porter et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Independent Association Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease in the US Population

(2012) Maria Stepanova et al.   Clinical Gastroenterology and Hepatology

Elevation of Alanine Transaminase and Markers of Liver Fibrosis After a Mixed Meal Challenge in Individuals with Type 2 Diabetes

(2012) E. Y. H. Khoo et al.   DIGESTIVE DISEASES AND SCIENCES

MetaboAnalyst 2.0--a comprehensive server for metabolomic data analysis

(2012) J. Xia et al.   NUCLEIC ACIDS RESEARCH

Alanine and aspartate aminotransferase and glutamine-cycling pathway: Their roles in pathogenesis of metabolic syndrome

(2012) Silvia Sookoian   WORLD JOURNAL OF GASTROENTEROLOGY

Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver disease

(2011) Silvia Sookoian et al.   ATHEROSCLEROSIS

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study

(2011) Neeraj Bhala et al.   HEPATOLOGY

Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter

(2010) Silvia Sookoian et al.   HEPATOLOGY

Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease

(2010) Giovanni Targher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Circulating levels and hepatic expression of molecular mediators of atherosclerosis in nonalcoholic fatty liver disease

(2009) Silvia Sookoian et al.   ATHEROSCLEROSIS

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Histopathology of Non-Alcoholic Fatty Liver Disease

(2009) Elizabeth M. Brunt   Clinics in Liver Disease

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

(2009) Silvia Sookoian et al.   JOURNAL OF LIPID RESEARCH

Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling

(2009) Yan Sun et al.   LABORATORY INVESTIGATION

Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis

(2009) Rui Liu et al.   LIVER INTERNATIONAL

Common variants at ten loci influence QT interval duration in the QTGEN Study

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Endogenously generated sulfur dioxide and its vasorelaxant effect in rats1

(2008) Shu-xu DU et al.   ACTA PHARMACOLOGICA SINICA

Aminotransferase Levels and 20-Year Risk of Metabolic Syndrome, Diabetes, and Cardiovascular Disease

(2008) Wolfram Goessling et al.   GASTROENTEROLOGY

Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects

(2008) S. Kechagias et al.   GUT

Regulatory Effect of Hydrogen Sulfide on Vascular Collagen Content in Spontaneously Hypertensive Rats

(2008) Xia ZHAO et al.   HYPERTENSION RESEARCH

Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: A systematic review

(2008) Silvia Sookoian et al.   JOURNAL OF HEPATOLOGY