Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure, and Weight Loss in Mice

(2017) Viktoria Gusarova et al.   ENDOCRINOLOGY

Exome-wide association study of plasma lipids in >300,000 individuals

(2017) Dajiang J Liu et al.   NATURE GENETICS

Angptl4 does not control hyperglucagonemia or α-cell hyperplasia following glucagon receptor inhibition

(2017) Haruka Okamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of lipid metabolism by angiopoietin-like proteins

(2016) Wieneke Dijk et al.   CURRENT OPINION IN LIPIDOLOGY

Angiopoietin-like protein 4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet mice

(2016) Yi Wang et al.   Molecular Medicine Reports

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

(2016) Luca A Lotta et al.   NATURE GENETICS

Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease

(2016) Anna Helgadottir et al.   NATURE GENETICS

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

(2016) Frederick E. Dewey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study

(2016) Frederick E. Dewey et al.   SCIENCE

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

(2016) Robert A. Scott et al.   Science Translational Medicine

The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking

(2016) Ren Zhang   Open Biology

Copeptin is an independent predictor of diabetic heart disease and death

(2015) Sofia Enhörning et al.   AMERICAN HEART JOURNAL

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys

(2015) Viktoria Gusarova et al.   JOURNAL OF LIPID RESEARCH

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Hepatic ANGPTL3 regulates adipose tissue energy homeostasis

(2015) Yan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience

(2015) William E. Kraus et al.   Journal of Cardiovascular Translational Research

Physiological regulation of lipoprotein lipase

(2014) Sander Kersten   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion

(2014) Viktoria Gusarova et al.   CELL

Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes

(2014) Valgerdur Steinthorsdottir et al.   NATURE GENETICS

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

(2014) Jason Flannick et al.   NATURE GENETICS

UK Biobank Data: Come and Get It

(2014) N. E. Allen et al.   Science Translational Medicine

Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population

(2013) Jane Z. Kuo et al.   DIABETOLOGIA

Genome-wide association study in a Chinese population with diabetic retinopathy

(2013) Wayne H.-H. Sheu et al.   HUMAN MOLECULAR GENETICS

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

(2013) Joshua C Denny et al.   NATURE BIOTECHNOLOGY

Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction

(2012) Anders Berg Jørgensen et al.   EUROPEAN HEART JOURNAL

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

Cohort Profile: The HUNT Study, Norway

(2012) S. Krokstad et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Remnant Cholesterol as a Causal Risk Factor for Ischemic Heart Disease

(2012) Anette Varbo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort

(2011) Yi-Cheng Chang et al.   CLINICAL ENDOCRINOLOGY

Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study

(2011)   DIABETOLOGIA

Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study

(2011) Abel N Kho et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

The Relationship Between Plasma Angiopoietin-like Protein 4 Levels, Angiopoietin-like Protein 4 Genotype, and Coronary Heart Disease Risk

(2010) Melissa C. Smart-Halajko et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations

(2010) J. C. Denny et al.   BIOINFORMATICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages

(2010) Laeticia Lichtenstein et al.   Cell Metabolism

A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)–Botnia study

(2010) B. Isomaa et al.   DIABETOLOGIA

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

A Highly Conserved Motif within the NH2-terminal Coiled-coil Domain of Angiopoietin-like Protein 4 Confers Its Inhibitory Effects on Lipoprotein Lipase by Disrupting the Enzyme Dimerization

(2009) Ming-hon Yau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Variation in ANGPTL4 Provides Insights into Protein Processing and Function

(2009) Wu Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Incretin-based therapies for type 2 diabetes mellitus

(2009) Julie A. Lovshin et al.   Nature Reviews Endocrinology