Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
出版年份 2016 全文链接
标题
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
作者
关键词
-
出版物
NATURE GENETICS
Volume 49, Issue 1, Pages 17-26
出版商
Springer Nature
发表日期
2016-11-15
DOI
10.1038/ng.3714
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- A Robust Example of Collider Bias in a Genetic Association Study
- (2016) Felix R. Day et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Numerous Genes in Loci Associated With Body Fat Distribution Are Linked to Adipose Function
- (2016) Ingrid Dahlman et al. DIABETES
- Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease
- (2016) Hanieh Yaghootkar et al. DIABETES
- Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene
- (2016) Joshua W. Knowles et al. JOURNAL OF CLINICAL INVESTIGATION
- The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux
- (2016) Varman T. Samuel et al. JOURNAL OF CLINICAL INVESTIGATION
- Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease
- (2016) NEW ENGLAND JOURNAL OF MEDICINE
- Pioglitazone after Ischemic Stroke or Transient Ischemic Attack
- (2016) Walter N. Kernan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
- (2016) Frederick E. Dewey et al. NEW ENGLAND JOURNAL OF MEDICINE
- New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
- (2016) Yingchang Lu et al. Nature Communications
- The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer
- (2015) Brandi M. Baughman et al. ACS Chemical Biology
- Adjusting for Heritable Covariates Can Bias Effect Estimates in Genome-Wide Association Studies
- (2015) Hugues Aschard et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface
- (2015) Gagan D. Gupta et al. CELL
- Abdominal obesity: a marker of ectopic fat accumulation
- (2015) Ulf Smith JOURNAL OF CLINICAL INVESTIGATION
- HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
- (2015) Daniel I Swerdlow et al. LANCET
- New genetic loci link adipose and insulin biology to body fat distribution
- (2015) Dmitry Shungin et al. NATURE
- A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
- (2015) Majid Nikpay et al. NATURE GENETICS
- The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
- (2015) et al. SCIENCE
- The genetics of lipid storage and human lipodystrophies
- (2015) Ann L. Robbins et al. TRENDS IN MOLECULAR MEDICINE
- Biological interpretation of genome-wide association studies using predicted gene functions
- (2015) Tune H. Pers et al. Nature Communications
- Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs
- (2014) Xiaoling Zhang et al. BMC GENOMICS
- Genetic Evidence for a Normal-Weight "Metabolically Obese" Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes
- (2014) H. Yaghootkar et al. DIABETES
- Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity
- (2014) R. A. Scott et al. DIABETES
- Distinct Developmental Profile of Lower-Body Adipose Tissue Defines Resistance Against Obesity-Associated Metabolic Complications
- (2014) Katherine E. Pinnick et al. DIABETES
- Adipose Tissue and Metabolic Alterations: Regional Differences in Fat Cell Size and Number Matter, But Differently: A Cross-Sectional Study
- (2014) Mikael Rydén et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance
- (2014) Felicity Payne et al. JOURNAL OF CLINICAL INVESTIGATION
- Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans
- (2014) Roshni R. Singaraja et al. JOURNAL OF LIPID RESEARCH
- The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
- (2014) Rachel J. Perry et al. NATURE
- Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
- (2014) Ron Do et al. NATURE
- A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
- (2014) Ida Moltke et al. NATURE
- Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins
- (2014) Alfonso Buil et al. NATURE GENETICS
- Defining the role of common variation in the genomic and biological architecture of adult human height
- (2014) Andrew R Wood et al. NATURE GENETICS
- Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes
- (2014) Fredrik Karpe et al. Nature Reviews Endocrinology
- Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease
- (2014) Anders Berg Jørgensen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease
- (2014) Gerald I. Shulman NEW ENGLAND JOURNAL OF MEDICINE
- Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Development of an OP9 Derived Cell Line as a Robust Model to Rapidly Study Adipocyte Differentiation
- (2014) Jacqueline M. Lane et al. PLoS One
- A Central Role for GRB10 in Regulation of Islet Function in Man
- (2014) Inga Prokopenko et al. PLoS Genetics
- PIK3R1 Mutations Cause Syndromic Insulin Resistance with Lipoatrophy
- (2013) Christel Thauvin-Robinet et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Mutations in PIK3R1 Cause SHORT Syndrome
- (2013) David A. Dyment et al. AMERICAN JOURNAL OF HUMAN GENETICS
- SHORT Syndrome with Partial Lipodystrophy Due to Impaired Phosphatidylinositol 3 Kinase Signaling
- (2013) Kishan Kumar Chudasama et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Comparison of the abilities of the plasma triglyceride/high-density lipoprotein cholesterol ratio and the metabolic syndrome to identify insulin resistance
- (2013) Martin R Salazar et al. Diabetes & Vascular Disease Research
- Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data
- (2013) Stephen Burgess et al. GENETIC EPIDEMIOLOGY
- Discovery and refinement of loci associated with lipid levels
- (2013) Cristen J Willer et al. NATURE GENETICS
- The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
- (2013) Danielle Welter et al. NUCLEIC ACIDS RESEARCH
- What causes the insulin resistance underlying obesity?
- (2013) Olga T. Hardy et al. Current Opinion in Endocrinology Diabetes and Obesity
- Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
- (2013) Joshua C. Randall et al. PLoS Genetics
- Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications
- (2013) Norbert Stefan et al. Lancet Diabetes & Endocrinology
- What makes UK Biobank special?
- (2012) Rory Collins LANCET
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- (2012) NATURE GENETICS
- Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
- (2012) Robert A Scott et al. NATURE GENETICS
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
- (2012) Alisa K Manning et al. NATURE GENETICS
- Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
- (2011) DIABETOLOGIA
- Genetic Syndromes of Severe Insulin Resistance
- (2011) Robert K. Semple et al. ENDOCRINE REVIEWS
- Adult height variants affect birth length and growth rate in children
- (2011) Lavinia Paternoster et al. HUMAN MOLECULAR GENETICS
- Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
- (2011) Tuomas O Kilpeläinen et al. NATURE GENETICS
- A linear complexity phasing method for thousands of genomes
- (2011) Olivier Delaneau et al. NATURE METHODS
- Pioglitazone for Diabetes Prevention in Impaired Glucose Tolerance
- (2011) Ralph A. DeFronzo et al. NEW ENGLAND JOURNAL OF MEDICINE
- HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
- (2011) L. D. Ward et al. NUCLEIC ACIDS RESEARCH
- Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective
- (2010) Sam Virtue et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- LocusZoom: regional visualization of genome-wide association scan results
- (2010) R. J. Pruim et al. BIOINFORMATICS
- Association Between Adiposity in Midlife and Older Age and Risk of Diabetes in Older Adults
- (2010) Mary L. Biggs JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Lipid-induced insulin resistance: unravelling the mechanism
- (2010) Varman T Samuel et al. LANCET
- Candidate Causal Regulatory Effects by Integration of Expression QTLs with Complex Trait Genetic Associations
- (2010) Alexandra C. Nica et al. PLoS Genetics
- Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis
- (2009) Daniel I. Chasman et al. PLoS Genetics
- SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
- (2008) A. D. Johnson et al. BIOINFORMATICS
- Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
- (2008) Adilson Guilherme et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- General and Abdominal Adiposity and Risk of Death in Europe
- (2008) T. Pischon et al. NEW ENGLAND JOURNAL OF MEDICINE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search