The Janus Face of Cereals: Wheat‐Derived Prebiotics Counteract the Detrimental Effect of Gluten on Metabolic Homeostasis in Mice Fed a High‐Fat/High‐Sucrose Diet

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2

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The DPP-4 inhibitor vildagliptin impacts the gut microbiota and prevents disruption of intestinal homeostasis induced by a Western diet in mice

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Fructan, Rather Than Gluten, Induces Symptoms in Patients With Self-Reported Non-Celiac Gluten Sensitivity

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Effects of a Gluten-Containing Meal on Gastric Emptying and Gallbladder Contraction

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Increased gut permeability in cancer cachexia: mechanisms and clinical relevance

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Wheat-derived arabinoxylan oligosaccharides with bifidogenic properties abolishes metabolic disorders induced by western diet in mice

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Sensitive detection of cereal fractions that are toxic to celiac disease patients by using monoclonal antibodies to a main immunogenic wheat peptide

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Gluten intake and risk of type 2 diabetes in three large prospective cohort studies of US men and women

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Klebsiella oxytoca expands in cancer cachexia and acts as a gut pathobiont contributing to intestinal dysfunction

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The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health

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A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

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Probiotics improve gut microbiota dysbiosis in obese mice fed a high-fat or high-sucrose diet

(2018) Cheng Kong et al.   NUTRITION

Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or With Obesity

(2017) Alissa C. Nicolucci et al.   GASTROENTEROLOGY

Nutritional Wheat Amylase-Trypsin Inhibitors Promote Intestinal Inflammation via Activation of Myeloid Cells

(2017) Victor F. Zevallos et al.   GASTROENTEROLOGY

Celiac Disease and Nonceliac Gluten Sensitivity

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What is gluten?

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Gluten-degrading bacteria are present in the human small intestine of healthy volunteers and celiac patients

(2017) Alexandra R. Herrán et al.   RESEARCH IN MICROBIOLOGY

Dietary Uncoupling of Gut Microbiota and Energy Harvesting from Obesity and Glucose Tolerance in Mice

(2017) Matthew J. Dalby et al.   Cell Reports

High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice

(2017) Liang Xiao et al.   Microbiome

The human digestive tract has proteases capable of gluten hydrolysis

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Effects of Gliadin consumption on the Intestinal Microbiota and Metabolic Homeostasis in Mice Fed a High-fat Diet

(2017) Li Zhang et al.   Scientific Reports

Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity

(2017) Francesco Suriano et al.   Scientific Reports

Randomized clinical trial: Effective gluten degradation by Aspergillus niger-derived enzyme in a complex meal setting

(2017) Julia König et al.   Scientific Reports

Long term effects of gluten-free diet in non-celiac wheat sensitivity

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Duodenal Bacteria From Patients With Celiac Disease and Healthy Subjects Distinctly Affect Gluten Breakdown and Immunogenicity

(2016) Alberto Caminero et al.   GASTROENTEROLOGY

Endurance Training Attenuates Catabolic Signals Induced by TNF-α in Muscle of Mice

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ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation

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Large Gliadin Peptides Detected in the Pancreas of NOD and Healthy Mice following Oral Administration

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Gut microorganisms as promising targets for the management of type 2 diabetes

(2015) Nathalie M. Delzenne et al.   DIABETOLOGIA

Wheat gluten intake increases weight gain and adiposity associated with reduced thermogenesis and energy expenditure in an animal model of obesity

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Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia

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Prolyl Endopeptidase Activity Is Correlated with Colorectal Cancer Prognosis

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Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity

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Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice

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Gliadin Fragments and a Specific Gliadin 33-mer Peptide Close KATP Channels and Induce Insulin Secretion in INS-1E Cells and Rat Islets of Langerhans

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Modulatory Effect of Gliadin Peptide 10-mer on Epithelial Intestinal CACO-2 Cell Inflammatory Response

(2013) Antonella Capozzi et al.   PLoS One

Short-Chain Fructo-Oligosaccharides Modulate Intestinal Microbiota and Metabolic Parameters of Humanized Gnotobiotic Diet Induced Obesity Mice

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Monitoring of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces

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Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women

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Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4

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Modulation of phenotypic and functional maturation of dendritic cells by intestinal bacteria and gliadin: relevance for celiac disease

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Gluten-free diet reduces adiposity, inflammation and insulin resistance associated with the induction of PPAR-alpha and PPAR-gamma expression

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The cellular and signaling networks linking the immune system and metabolism in disease

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Wheat-derived arabinoxylan oligosaccharides with prebiotic effect increase satietogenic gut peptides and reduce metabolic endotoxemia in diet-induced obese mice

(2012) A M Neyrinck et al.   Nutrition & Diabetes

Prebiotic and Other Health-Related Effects of Cereal-Derived Arabinoxylans, Arabinoxylan-Oligosaccharides, and Xylooligosaccharides

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Bifidobacteria inhibit the inflammatory response induced by gliadins in intestinal epithelial cells via modifications of toxic peptide generation during digestion

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A Food-Grade Enzyme Preparation with Modest Gluten Detoxification Properties

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Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3

(2008) Karen M. Lammers et al.   GASTROENTEROLOGY

Toward the Assessment of Food Toxicity for Celiac Patients: Characterization of Monoclonal Antibodies to a Main Immunogenic Gluten Peptide

(2008) Belén Morón et al.   PLoS One