Article
Immunology
Maria Jose Perez-Saez, Audrey Uffing, Juliette Leon, Naoka Murakami, Andreia Watanabe, Thiago J. Borges, Venkata S. Sabbisetti, Pamela Cureton, Victoria Kenyon, Leigh Keating, Karen Yee, Carla Aline Fernandes Satiro, Gloria Serena, Friedhelm Hildebrandt, Cristian Riella, Towia A. Libermann, Minxian Wang, Julio Pascual, Joseph Bonventre, Paolo Cravedil, Alessio Fasano, Leonardo Riella
Summary: The study found that a gluten-free and dairy-free diet had a significant anti-inflammatory effect in children with steroid-resistant nephrotic syndrome, promoting a favorable regulatory gut microbiota and increasing T regulatory/T helper 17 cells ratio. Further trials are necessary to explore the potential of this dietary intervention in children with SRNS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Any Elisa de Souza Schmidt Goncalves, Guilherme Zweig Rocha, Rodrigo Marin, Rafael Ludemann Camargo, Andrey dos Santos, Helison do Carmo, Dioze Guadagnini, Orlando Petrucci, Zenaide Providello Moyses, Vera Maria Cury Salemi, Alexandre Gabarra Oliveira, Mario Jose Abdalla Saad
Summary: Diet-induced obesity can lead to pulmonary hypertension, potentially involving PPAR-gamma and ER stress. Treatment with pioglitazone can improve insulin resistance and pulmonary hypertension, increasing the expression of adiponectin and PPAR-gamma in the pulmonary artery.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Guang Ren, Patrick Tae Joon Hwang, Reid Millican, Juhee Shin, Brigitta C. Brott, Thomas van Groen, Craig M. Powell, Sushant Bhatnagar, Martin E. Young, Ho-Wook Jun, Jeong-A Kim
Summary: This study demonstrates the effects of using PANO gel to inject exogenous NO on high-fat diet-induced obesity, insulin resistance, and cognitive functions. The use of PANO gel reduces body weight gain, improves glucose tolerance, decreases insulin and leptin levels, and enhances insulin signaling. Additionally, the PANO gel reduces inflammation, increases lipolysis, decreases serum lipids and liver triglycerides, stimulates the development of brown and beige fat tissues, increases cerebral blood flow, and improves learning and memory abilities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nutrition & Dietetics
Allison M. Hodge, Md Nazmul Karim, James R. Hebert, Nitin Shivappa, Barbora de Courten
Summary: The study found that dietary inflammatory index and Alternative Healthy Eating Index-2010 were positively associated with diabetes incidence, while Mediterranean Diet Score was not. Mediation analysis indicated that body size played a moderate to large mediating role in the association between AHEI and DII and incident diabetes.
Article
Biochemistry & Molecular Biology
Jose Alberto Molina-Tijeras, Antonio Jesus Ruiz-Malagon, Laura Hidalgo-Garcia, Patricia Diez-Echave, Maria Jesus Rodriguez-Sojo, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Jose Perez del Palacio, Maria Reyes Gonzalez-Tejero, Maria Elena Rodriguez-Cabezas, Julio Galvez, Alba Rodriguez-Nogales, Teresa Vezza, Francesca Algieri
Summary: Obesity, a global public health problem, is increasing in prevalence rate. Plant-based treatments, such as Lavandula multifida extract (LME), have been gaining attention as a means to manage obesity and its comorbidities. In this study, LME was found to reduce weight gain, improve insulin sensitivity and glucose tolerance, decrease inflammation in the liver and adipose tissue, regulate gut permeability, and reduce oxidative stress. These findings suggest that LME may be a promising supplementary approach for managing obesity and its comorbidities.
Article
Plant Sciences
Rasidat O. Tijani, Jose Alberto Molina-Tijeras, Teresa Vezza, Antonio Jesus Ruiz-Malagon, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Oyindamola O. Abiodun, Julio Galvez
Summary: The methanol extract of Myrianthus arboreus leaf showed significant therapeutic effects in a mice model of metabolic syndrome induced by a high-fat diet, including reducing weight gain, improving blood sugar and insulin resistance, and enhancing lipid profile. Additionally, the extract demonstrated potential in treating metabolic disorders through modulation of inflammatory status and gene expression related to obesity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Pauline S. Effting, Anand Thirupathi, Alexandre P. Muller, Barbara C. Pereira, Diane M. Sepa-Kishi, Luis F. B. Marqueze, Franciane T. F. Vasconcellos, Renata T. Nesi, Talita C. B. Pereira, Luiza W. Kist, Mauricio R. Bogo, Rolando B. Ceddia, Ricardo A. Pinho
Summary: This study found that ladder climbing, as a model of resistance exercise, can reverse the metabolic and inflammatory effects of high-fat diet-induced obesity in mice. The training reduced body weight, adipocyte size, improved glycemic control, and reduced inflammation in skeletal muscles.
Review
Nutrition & Dietetics
Bara Aljada, Ahmed Zohni, Wael El-Matary
Summary: The gluten-free diet is popular for treating immune-mediated disorders caused by gluten, but it has disadvantages like high costs, nutritional deficiencies, and social and psychological barriers. Close follow-up with patients following the diet is recommended, and more data is needed to assess its effectiveness in managing mental and cognitive disorders.
Review
Nutrition & Dietetics
Soghra Bagheri, Samaneh Zolghadri, Agata Stanek
Summary: Obesity is linked to metabolic abnormalities, cardiovascular diseases, and cancer. The rate of obesity has increased in recent decades, and there is a connection between obesity and the gut microbiota. Inflammation plays a role in this connection. Anti-inflammatory nutrients, foods, and diets are important in managing obesity.
Article
Multidisciplinary Sciences
Payal Kapoor, Apoorv Tiwari, Saloni Sharma, Vandita Tiwari, Bhawna Sheoran, Usman Ali, Monika Garg
Summary: Researchers found that anthocyanin-rich diets have a significant impact on gut flora. Conducting large-scale trials is challenging, so merging data from small studies can be helpful. This comprehensive meta-analysis examined the influence of anthocyanins on Firmicutes/Bacteroide ratio and short-chain fatty acids. The results showed that anthocyanin-rich diets reduced the ratio and had the highest impact on acetic acid among three SCFAs. The meta-analysis provided strong evidence that anthocyanin supplementation improves gut health biomarkers.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Bingyang Dai, Jiankun Xu, Xu Li, Le Huang, Chelsea Hopkins, Honglian Wang, Hao Yao, Jie Mi, Lizhen Zheng, Jiali Wang, Wenxue Tong, Dick Ho-Kiu Chow, Ye Li, Xuan He, Peijie Hu, Ziyi Chen, Haiyue Zu, Yixuan Li, Yao Yao, Qing Jiang, Ling Qin
Summary: This study found that osteopontin secreted by epididymal white adipose tissue activates osteoclasts and promotes bone matrix degradation. It also modulates macrophages to engulf lipid droplets released from adipocytes. Surgical removal of adipose tissue or injection of antibodies can alleviate high-fat diet-induced bone loss.
NATURE COMMUNICATIONS
(2022)
Review
Nutrition & Dietetics
Giuseppe Defeudis, Maria Chiara Massari, Giovanni Terrana, Lucia Coppola, Nicola Napoli, Silvia Migliaccio
Summary: Celiac disease is increasingly being diagnosed, and the only available treatment is a gluten-free diet (GFD). The impact of gluten on metabolic syndrome and related inflammatory response is still uncertain due to conflicting results. Research on the role of the GFD in glycometabolic parameters, vitamin D, and inflammatory cytokines is necessary. This narrative review provides evidence on the effects of the GFD on various metabolic parameters, but the overall impact on metabolic syndrome components remains unclear.
Article
Biochemical Research Methods
Lei Huang, Qinzhu Bai, Zhuoran Wang, Xu Zhang, Kexuan Liu, Jing Cui, Liuyi Du, Shuchen Liu, Yunhe Fu, Huan Wang, Daowei Li, Hongchen Sun
Summary: Nonalcoholic fatty liver disease (NAFLD) is a significant metabolic disease worldwide and is linked to systemic inflammation and the development of extrahepatic complications. Current treatments for NAFLD are limited in effectiveness and safety. This study demonstrates that pharmacologically active carbon dots derived from metformin can selectively accumulate in the liver, improve NAFLD, and also benefit other organs and tissues. This research presents a feasible and safe strategy to target the liver and treat NAFLD and its associated complications.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Seung Yeon Park, Hyun Jung Lee, Jin-Ho Song, Yong Kyoo Shin, A. M. Abd El-Aty, Amer Ramadan, A. Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jung
Summary: In summary, DITA treatment attenuated palmitate-induced impairment of insulin signaling and inflammation in C2C12 myocytes by enhancing AMPK phosphorylation, PPAR delta expression, and FGF21 secretion. This study suggests that targeting the AMPK/FGF21/PPAR delta pathway may alleviate insulin resistance in skeletal muscle cells.
Article
Biotechnology & Applied Microbiology
Xiaozhong Huang, Qingguo Cao, Cen Chen, Zhenglin Xie, Jinshan Fan
Summary: This study investigates the effects of fermented barley extracts on obesity and inflammatory responses, and suggests that these extracts could be beneficial in improving inflammatory status and gut microflora.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Psychology, Clinical
Edna M. Sant'Anna, Sara P. C. Paiva, Raphael P. Santos, Ana M. S. Rodrigues, Nakita A. Davis, Simone F. Nery, Fernanda P. Maia, Adaliene V. M. Ferreira, Fernando M. Reis
Summary: In the short term, the mindfulness-based program did not lead to weight loss in infertile women, but it did contribute to a reduction in waist circumference, possibly due to a decrease in food energy intake.
JOURNAL OF PSYCHOSOMATIC OBSTETRICS & GYNECOLOGY
(2022)
Article
Immunology
Luciana Maria Oliveira, Denise Silva Nogueira, Ricardo Marcelo Geraldi, Fernando Sergio Barbosa, Chiara Cassia Oliveira Amorim, Ana Clara Gazzinelli-Guimaraes, Nathalia Maria Resende, Natalia Pinheiro-Rosa, Lucas Rocha Kraemer, Matheus Silverio Mattos, Lilian Lacerda Bueno, Ana Maria Caetano Faria, Remo Castro Russo, Soraya Gaze, Ricardo Toshio Fujiwara
Summary: This study evaluates the kinetic aspects of immune parasitological parameters in male mice with early ascariasis, and suggests a synergetic action of intestinal and pulmonary secretory IgA contributing to protection against early ascariasis by reducing the amount of migrating larvae and leukocyte influx.
INFECTION AND IMMUNITY
(2022)
Article
Neurosciences
Mariele Lino Silva, Lais Bhering Martins, Luana Caroline dos Santos, Gilberto Simeone Henriques, Antonio Lucio Teixeira, Ana Maria dos Santos Rodrigues, Adaliene Versiani Matos Ferreira
Summary: This study suggests that patients with migraine have lower plasma levels of minerals and lower dietary intake of minerals compared to individuals without migraine. It highlights the importance of dietary intervention to ensure adequate mineral intake as a therapeutic strategy for migraine.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Joaquim Pedro Brito-de-Sousa, Ana Carolina Campi-Azevedo, Ismael Artur da Costa-Rocha, Jesuanne Carla Silva-Andrade, Lizandra Morgado-Santos, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhaes, Matheus de Souza Gomes, Laurence Rodrigues Amaral, Andrea Teixeira-Carvalho, Thadia Evelyn Araujo, Eloisa Amalia Vieira Ferro, Rosiane Aparecida da Silva-Pereira, Lis Ribeiro do Valle Antonelli, Ana Maria Caetano de Faria, Angelica Oliveira Gomes, Olindo Assis Martins-Filho
Summary: This study reveals the impact of ageing on the pattern of serum soluble mediators. It shows a bimodal profile of serum soluble mediators, with one peak at 6-10 years and a second wave around 61-70 years. The study also identifies universal age-related biomarkers and differences in magnitude and timing between sexes.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Immunology
Ana Carolina de Sena Avellar, Mariana Naves Oliveira, Felipe Caixeta, Rafaela Cristina Vieira e Souza, Andrea Teixeira, Ana Maria Caetano Faria, Gabriela Silveira-Nunes, Elaine Spezialli Faria, Tatiani Uceli Maioli
Summary: Gestational diabetes mellitus (GDM) can affect the concentration of biomarkers in colostrum, potentially impacting the development of the newborn's immune system.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Anne C. S. Ramos, Luciana M. Oliveira, Yvanna L. D. C. O. Santos, Marlon C. S. Dantas, Cristiani I. B. Walker, Ana M. C. Faria, Lilian L. Bueno, Silvio S. Dolabella, Ricardo T. Fujiwara
Summary: This systematic review aimed to investigate the role of Immunoglobulin-A (IgA) as a mediator of protective immunity against gastrointestinal helminths. The results showed consistent associations between higher IgA levels and lower parasitological parameters in mice, rats, and sheep. However, the role of IgA in other host species remained uncertain, highlighting the need for further research.
IMMUNOLOGY LETTERS
(2022)
Article
Immunology
Maria Cecilia Campos Canesso, Thais Garcias Moreira, Ana Maria Caetano Faria
Summary: The intestine is a complex organ with specific niches and microenvironments filled with different cell types that are involved in physiological and inflammatory processes. The specialized environments within the intestine are critical for the development and functional adaptation of immune cells in the gut and gut-draining lymph nodes.
IMMUNOLOGY LETTERS
(2022)
Article
Cell Biology
D. F. Durso, G. Silveira-Nunes, M. M. Coelho, G. C. Camatta, L. H. Ventura, L. S. Nascimento, F. Caixeta, E. H. M. Cunha, A. Castelo-Branco, D. M. Fonseca, T. U. Maioli, A. Teixeira-Carvalho, C. Sala, M. J. Bacalini, P. Garagnani, C. Nardini, C. Franceschi, A. M. C. Faria
Summary: Living in endemic areas for chronic infectious diseases results in remodeling of inflammaging and acceleration of epigenetic aging in individuals regardless of their infectious status.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Article
Cell Biology
Mauro A. F. Guimaraes, Natalia Pinheiro-Rosa, Rafael P. Oliveira, Sarah L. F. Aguiar, Mariana C. G. Miranda, Luisa Lemos, Adna L. Souza, Daniela S. dos Reis, Samara R. Medeiros, William A. Goncalves, Sylvia S. Amaral, Vanessa Pinho, Anderson Miyoshi, Vasco A. Z. Azevedo, Rafael M. Rezende, Ana M. C. Faria
Summary: Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system. In this study, a protocol of oral tolerance induction using HSP65-producing Lactococcus lactis was proposed and successfully prevented and controlled MOG-induced experimental autoimmune encephalomyelitis (EAE) in mice. The treatment resulted in a reduction in EAE clinical score, higher frequencies of regulatory T cells, and reduced leukocyte adherence in the spinal cord. These findings suggest a novel therapeutic strategy for MS and other autoimmune diseases.
CELLULAR IMMUNOLOGY
(2023)
Editorial Material
Immunology
Licia Torres, Ana M. C. Faria
Summary: This study demonstrates that gut regionalization can affect microbiota and immunity through the regulation of GATA4 expression, which controls bacterial colonization, retinol metabolism, and IgA production. This metabolic-immune axis plays a crucial role in limiting intestinal Th17 responses and immunopathology.
Article
Microbiology
Juliana Lima Alves, Luisa Lemos, Nubia Morais Rodrigues, Vanessa Bastos Pereira, Patricia A. Vieira Barros, Maria Cecilia Campos Canesso, Mauro A. F. Guimaraes, Denise Carmona Cara, Anderson Miyoshi, Vasco Ariston Azevedo, Tatiani Uceli Maioli, Ana Cristina Gomes-Santos, Ana Maria Caetano Faria
Summary: Inflammatory bowel diseases (IBD) are gastrointestinal disorders characterized by a breakdown in intestinal homeostasis by inflammatory immune responses. Novel strategies for ameliorating IBD have been proposed. The study showed that different strains of Lactococcus lactis improved clinical scores and parameters of colitis, confirming their anti-inflammatory properties in this model.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Review
Nutrition & Dietetics
Gabriela Barbosa Pires Fagundes, Jenneffer Rayane Braga Tibaes, Mariele Lino Silva, Marina Marcolino Braga, Ana Leticia Malheiros Silveira, Antonio Lucio Teixeira, Adaliene Versiani Matos Ferreira
Summary: The objective of this study was to evaluate the effects of 8 weeks of time-restricted eating (TRE) with a caloric restriction on metabolic profile, metabolic rate, symptoms of mood and eating disorders, and weight loss in women with overweight or obesity. The results showed that subjects in the TRE group experienced more pronounced weight loss, body fat mass loss, and fat-free mass loss compared to those in the non-TRE group. However, these losses were not associated with changes in resting metabolic rate, metabolic profile, or symptoms of eating or mood disorders. In conclusion, 8 weeks of TRE does not influence behavioral parameters in individuals with overweight or obesity, but may lead to weight loss.
Article
Biotechnology & Applied Microbiology
Vivian C. Miranda, Ramon O. Souza, Monica F. Quintanilha, Bruno Gallotti, Helder C. Assis, Ana Maria C. Faria, Jacques R. Nicoli, Denise C. Cara, Flaviano S. Martins
Summary: This study aimed to evaluate the probiotic and postbiotic potential of Akkermansia muciniphila BAA-835 in an ovalbumin food allergy model. The results showed that treatment with viable A. muciniphila could alleviate weight loss, decrease serum levels of allergy-related antibodies, reduce intestinal injury and inflammation, and modify the gut microbiota composition. Additionally, the administration of inactivated bacteria also had a postbiotic effect by reducing allergy-related immune responses. These findings suggest that A. muciniphila BAA-835 has both probiotic and postbiotic properties in the prevention and treatment of food allergies.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Nutrition & Dietetics
Renato Elias Moreira-Junior, Mauro Andrade de Freitas Guimaraes, Miguel Etcheverria da Silva, Tatiani Uceli Maioli, Ana Maria Caetano Faria, Ana Lucia Brunialti-Godard
Summary: Mechanisms that dictate ethanol preference and addiction are not limited to the central nervous system, but also involve the immune system and gene transcription in the reward system. This study aimed to assess the impact of problematic alcohol consumption on the transcriptional profile of the Lrrk2 gene, neuroinflammation, and behavior, and investigate their interconnections.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Katia Anunciacao Costa, Marina Chaves de Oliveira, Leticia Maria de Souza Cordeiro, Cynthia Honorato Val, Fabiana Simao Machado, Simone Odilia Antunes Fernandes, Valbert Nascimento Cardoso, Mauro Martins Teixeira, Ana Leticia Malheiros Silveira, Adaliene Versiani Matos Ferreira
Summary: This study aims to evaluate the effects of a high-refined carbohydrate (HC) diet on small intestine changes. Male BALB/c mice were fed an HC diet for 8 weeks, and it was found that although there were no significant differences in body weight gain, mice fed the HC diet exhibited adiposity and metabolic alterations. However, there were no significant changes observed in intestinal integrity, tight junction protein expression, intestinal permeability, and bacterial translocation.
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)