The cellular and signaling networks linking the immune system and metabolism in disease

Hypoxia and Hypoxia-Inducible Factor-1  Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function

(2014) J. Jantsch et al.   JOURNAL OF IMMUNOLOGY

The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet-Fed Mice

(2011) C. Jiang et al.   DIABETES

Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice

(2011) Xavier Prieur et al.   DIABETES

Selective Inactivation of c-Jun NH2-Terminal Kinase in Adipose Tissue Protects Against Diet-Induced Obesity and Improves Insulin Sensitivity in Both Liver and Skeletal Muscle in Mice

(2011) X. Zhang et al.   DIABETES

High-Fat Diet-Induced Adipocyte Cell Death Occurs Through a Cyclophilin D Intrinsic Signaling Pathway Independent of Adipose Tissue Inflammation

(2011) D. Feng et al.   DIABETES

Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance

(2011) N. Sachithanandan et al.   DIABETES

Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet-Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis

(2011) F. C. McGillicuddy et al.   DIABETES

Fractalkine Is a Novel Human Adipochemokine Associated With Type 2 Diabetes

(2011) R. Shah et al.   DIABETES

Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice

(2011) G. M. Kowalski et al.   DIABETOLOGIA

Association Between Disease-Modifying Antirheumatic Drugs and Diabetes Risk in Patients With Rheumatoid Arthritis and Psoriasis

(2011) Daniel H. Solomon   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Interleukin-6 Protects Human Macrophages from Cellular Cholesterol Accumulation and Attenuates the Proinflammatory Response

(2011) Eric Frisdal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment with Anakinra Improves Disposition Index But Not Insulin Sensitivity in Nondiabetic Subjects with the Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study

(2011) Edwin J. P. van Asseldonk et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Gut microbiome, obesity, and metabolic dysfunction

(2011) Herbert Tilg et al.   JOURNAL OF CLINICAL INVESTIGATION

Krüppel-like factor 4 regulates macrophage polarization

(2011) Xudong Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency of the Leukotriene B4 Receptor, BLT-1, Protects against Systemic Insulin Resistance in Diet-Induced Obesity

(2011) M. Spite et al.   JOURNAL OF IMMUNOLOGY

Human nutrition, the gut microbiome and the immune system

(2011) Andrew L. Kau et al.   NATURE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Serial changes in inflammatory biomarkers after Roux-en-Y gastric bypass surgery

(2011) Gary D. Miller et al.   Surgery for Obesity and Related Diseases

Absence of macrophage inflammatory protein-1α does not impact macrophage accumulation in adipose tissue of diet-induced obese mice

(2010) Bonnie K. Surmi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats

(2010) Swarup K. Chakrabarti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

PKCζ-Regulated Inflammation in the Nonhematopoietic Compartment Is Critical for Obesity-Induced Glucose Intolerance

(2010) Sang Jun Lee et al.   Cell Metabolism

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis

(2010) A. E. Obstfeld et al.   DIABETES

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

(2010) V. B. Matthews et al.   DIABETOLOGIA

Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression

(2010) M Zeyda et al.   INTERNATIONAL JOURNAL OF OBESITY

Functional Heterogeneity of CD11c-positive Adipose Tissue Macrophages in Diet-induced Obese Mice

(2010) Pingping Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome

(2010) Takara L. Stanley et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Diet, gut microbiota and immune responses

(2010) Kendle M Maslowski et al.   NATURE IMMUNOLOGY

T-Cell Recruitment and Th1 Polarization in Adipose Tissue During Diet-Induced Obesity in C57BL/6 Mice

(2010) Katherine J. Strissel et al.   Obesity

The role of inflammation and macrophage accumulation in the development of obesity-induced type 2 diabetes mellitus and the possible therapeutic effects of long-chain n-3 PUFA

(2010) Elizabeth Oliver et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity

(2010) N. Ouchi et al.   SCIENCE

Myeloid Cell-Restricted Insulin Receptor Deficiency Protects Against Obesity-Induced Inflammation and Systemic Insulin Resistance

(2010) Jan Mauer et al.   PLoS Genetics

Kupffer cell activation is a causal factor for hepatic insulin resistance

(2009) Nicolas Lanthier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin

(2009) Janet E. Digby et al.   ATHEROSCLEROSIS

Critical role of Kupffer cells in the management of diet-induced diabetes and obesity

(2009) Audrey M. Neyrinck et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adipocyte CREB Promotes Insulin Resistance in Obesity

(2009) Ling Qi et al.   Cell Metabolism

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle

(2009) E.-G. Hong et al.   DIABETES

Gene Profiling of Human Adipose Tissue During Evoked Inflammation In Vivo

(2009) R. Shah et al.   DIABETES

Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice

(2009) S. Fujisaka et al.   DIABETES

How safe is the use of thiazolidinediones in clinical practice?

(2009) CV Rizos et al.   Expert Opinion On Drug Safety

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue

(2009) R W O'Rourke et al.   INTERNATIONAL JOURNAL OF OBESITY

Keratinocyte-derived Chemokine in Obesity

(2009) Jaap G. Neels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Muscle c-Jun NH2-Terminal Kinase 1 in Obesity-Induced Insulin Resistance

(2009) G. Sabio et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

(2009) Jian Liu et al.   NATURE MEDICINE

Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71

(2009) Yorihiro Nishimura et al.   NATURE MEDICINE

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

PPARγ activation in adipocytes is sufficient for systemic insulin sensitization

(2009) Shigeki Sugii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of PPARγ function by TNF-α

(2008) Jianping Ye   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism

(2008) Thien T. Tran et al.   Cell Metabolism

Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity

(2008) Leonie Heilbronn et al.   CURRENT PHARMACEUTICAL DESIGN

Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity

(2008) O. Osborn et al.   CYTOKINE

Blockade of  4 Integrin Signaling Ameliorates the Metabolic Consequences of High-Fat Diet-Induced Obesity

(2008) C. C. Feral et al.   DIABETES

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

(2008) J. M. Haus et al.   DIABETES

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

The Antiinflammatory Cytokine Interleukin-1 Receptor Antagonist Protects from High-Fat Diet-Induced Hyperglycemia

(2008) Nadine S. Sauter et al.   ENDOCRINOLOGY

Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice

(2008) Mathieu Membrez et al.   FASEB JOURNAL

Increased Cellular Free Cholesterol in Macrophage-specificAbca1Knock-out Mice Enhances Pro-inflammatory Response of Macrophages

(2008) Xuewei Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE

Genetics of gene expression and its effect on disease

(2008) Valur Emilsson et al.   NATURE

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

(2008) G. Sabio et al.   SCIENCE