SIRT6, a Mammalian deacylase with multitasking abilities

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

(2019) Xiao Tian et al.   CELL

Sirt4 is a mitochondrial regulator of metabolism and lifespan inDrosophila melanogaster

(2018) Jason G. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway

(2018) Irene Santos-Barriopedro et al.   Nature Communications

SIRT6 facilitates directional telomere movement upon oxidative damage

(2018) Ying Gao et al.   Scientific Reports

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

(2018) Weiqi Zhang et al.   NATURE

SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling

(2018) Thomas Strub et al.   Nature Communications

Natural polyphenols as sirtuin 6 modulators

(2018) Minna Rahnasto-Rilla et al.   Scientific Reports

Identification of a cellularly active SIRT6 allosteric activator

(2018) Zhimin Huang et al.   Nature Chemical Biology

Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model

(2017) Giovanna Sociali et al.   FASEB JOURNAL

SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition

(2017) Jiangping He et al.   FEBS Journal

Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice

(2017) Xiwen Xiong et al.   JOURNAL OF ENDOCRINOLOGY

Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6

(2017) María A. Zorrilla-Zubilete et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity

(2017) Przemysław L. Wencel et al.   MOLECULAR NEUROBIOLOGY

Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat

(2017) Lu Yao et al.   Cell Reports

SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion

(2017) Qiang Chen et al.   Cell Reports

Neuroprotective Functions for the Histone Deacetylase SIRT6

(2017) Shai Kaluski et al.   Cell Reports

Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice

(2017) Wen Chen et al.   Cell Reports

The Sirt6 gene: Does it play a role in tooth development?

(2017) Xueyang Liao et al.   PLoS One

Characterization of physiological defects in adult SIRT6-/- mice

(2017) Victoria Peshti et al.   PLoS One

A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes

(2016) Wesley Wei Wang et al.   ACS Chemical Biology

Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules

(2016) Weijie You et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

(2016) Sita Kugel et al.   CELL

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

(2016) Huize Pan et al.   CELL RESEARCH

SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling

(2016) Hu Wang et al.   Cell Stem Cell

SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein-Dependent Apoptotic Pathway

(2016) L.-K. Ran et al.   CLINICAL CANCER RESEARCH

SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

(2016) Berta N Vazquez et al.   EMBO JOURNAL

High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects

(2016) Jingwen Yu et al.   JOURNAL OF NEUROCHEMISTRY

LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56

(2016) Abhinav K. Jain et al.   MOLECULAR CELL

Identifying the functional contribution of the defatty-acylase activity of SIRT6

(2016) Xiaoyu Zhang et al.   Nature Chemical Biology

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage

(2016) Angela Rizzo et al.   NUCLEIC ACIDS RESEARCH

A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity

(2016) J Cai et al.   ONCOGENE

SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC

(2016) Namgyu Lee et al.   PLoS One

SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions

(2016) Abhishek Bhardwaj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway

(2016) Lihong Bai et al.   Oncotarget

Lysine fatty acylation promotes lysosomal targeting of TNF-α

(2016) Hong Jiang et al.   Scientific Reports

Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis

(2016) Sivan Elhanati et al.   Cell Reports

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks

(2016) Michael Van Meter et al.   Cell Reports

SIRT6 Is a Positive Regulator of Aldose Reductase Expression in U937 and HeLa cells under Osmotic Stress: In Vitro and In Silico Insights

(2016) Ahmet Can Timucin et al.   PLoS One

p53-dependent SIRT6 expression protects Aβ42-induced DNA damage

(2016) Eun Sun Jung et al.   Scientific Reports

Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway

(2016) Mi-Young Song et al.   Scientific Reports

Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells

(2016) J. R. Baker et al.   Scientific Reports

Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

(2015) Michele Cea et al.   BLOOD

SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9–Rad1–Hus1 checkpoint clamp

(2015) Bor-Jang Hwang et al.   BMC MOLECULAR BIOLOGY

SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner

(2015) Zhu Xu et al.   CELL CYCLE

A FRET-based assay for screening SIRT6 modulators

(2015) Yan Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Putative tumor suppression function of SIRT6 in endometrial cancer

(2015) Tomohiko Fukuda et al.   FEBS LETTERS

Cyclic AMP Signaling Reduces Sirtuin 6 Expression in Non-small Cell Lung Cancer Cells by Promoting Ubiquitin-Proteasomal Degradation via Inhibition of the Raf-MEK-ERK (Raf/Mitogen-activated Extracellular Signal-regulated Kinase/Extracellular Signal-regulated Kinase) Pathway

(2015) Eui-Jun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

(2015) Yuya Nishida et al.   MOLECULAR CELL

The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

(2015) Jean-Pierre Etchegaray et al.   NATURE CELL BIOLOGY

Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte

(2015) Longsen Han et al.   Scientific Reports

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer

(2015) Sita Kugel et al.   Cell Reports

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation

(2015) Yuko Atsumi et al.   Cell Reports

SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin Cancer

(2014) M. Ming et al.   CANCER RESEARCH

Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism

(2014) Selma Masri et al.   CELL

Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity

(2014) Rommel A. Mathias et al.   CELL

miR-34a/SIRT6 in squamous differentiation and cancer

(2014) G Paolo Dotto et al.   CELL CYCLE

Sirtuins, metabolism, and DNA repair

(2014) Jee-Eun Choi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

SIRT6 Is Required for Normal Retinal Function

(2014) Dafne M. Silberman et al.   PLoS One

SIRT6 Minor Allele Genotype Is Associated with >5-Year Decrease in Lifespan in an Aged Cohort

(2014) Mindi J. TenNapel et al.   PLoS One

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

(2014) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT6 Regulates Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells Partially via Suppressing the Nuclear Factor-κB Signaling Pathway

(2014) Hualing Sun et al.   STEM CELLS

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer

(2014) Y Chen et al.   Cell Death & Disease

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer

(2013) Mattaka Khongkow et al.   CARCINOGENESIS

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

A miR-34a-SIRT6 axis in the squamous cell differentiation network

(2013) Karine Lefort et al.   EMBO JOURNAL

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

(2013) L. Serrano et al.   GENES & DEVELOPMENT

Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients

(2013) Jens U. Marquardt et al.   HEPATOLOGY

The Role of SIRT6 Protein in Aging and Reprogramming of Human Induced Pluripotent Stem Cells

(2013) Amit Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxO3 Transcription Factor and Sirt6 Deacetylase Regulate Low Density Lipoprotein (LDL)-cholesterol Homeostasis via Control of the Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Gene Expression

(2013) Rongya Tao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals

(2013) M. Jedrusik-Bode et al.   JOURNAL OF CELL SCIENCE

Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence

(2013) N. Takasaka et al.   JOURNAL OF IMMUNOLOGY

The Ubiquitin Ligase CHIP Prevents SirT6 Degradation through Noncanonical Ubiquitination

(2013) Sarah M. Ronnebaum et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling

(2013) Debra Toiber et al.   MOLECULAR CELL

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

(2013) Annamaria Biroccio et al.   NATURE CELL BIOLOGY

SIRT6 exhibits nucleosome-dependent deacetylase activity

(2013) R. Gil et al.   NUCLEIC ACIDS RESEARCH

Altered expression of SIRT gene family in head and neck squamous cell carcinoma

(2013) Chi-Chih Lai et al.   TUMOR BIOLOGY

Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling

(2013) Federica Simeoni et al.   Scientific Reports

USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation

(2013) Zhenghong Lin et al.   Cell Reports

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

(2013) Jiyung Shin et al.   Cell Reports

Multiple Regulatory Layers of SREBP1/2 by SIRT6

(2013) Sivan Elhanati et al.   Cell Reports

Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics

(2013) Yewei Liu et al.   Protein & Cell

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

The NAD+-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca2+Responses

(2012) Inga Bauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin Catalysis and Regulation

(2012) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response

(2012) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progression of Chronic Liver Inflammation and Fibrosis Driven by Activation of c-JUN Signaling inSirt6Mutant Mice

(2012) Cuiying Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging

(2012) Gaoxiang Jia et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis

(2012) John E. Dominy et al.   MOLECULAR CELL

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin

(2012) Lihua Min et al.   NATURE CELL BIOLOGY

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

(2012) Nagalingam R Sundaresan et al.   NATURE MEDICINE

Identification of Novel Interacting Partners of Sirtuin6

(2012) Oxana Polyakova et al.   PLoS One

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence

(2012) Z. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C. elegans SIRT6/7 Homolog SIR-2.4 Promotes DAF-16 Relocalization and Function during Stress

(2012) Wei-Chung Chiang et al.   PLoS Genetics

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6

(2011) Eriko Michishita et al.   CELL CYCLE

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

(2011) Bo Yang et al.   CELL CYCLE

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

(2011) Michael Van Meter et al.   CELL CYCLE

Structure and Biochemical Functions of SIRT6

(2011) Patricia W. Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks

(2011) Tiara L. A. Kawahara et al.   PLoS Genetics

DAF-16/Forkhead Box O Transcription Factor: Many Paths to a Single Fork(head) in the Road

(2010) Kelvin Yen et al.   ANTIOXIDANTS & REDOX SIGNALING

Sterol metabolism and SREBP activation

(2010) Ryuichiro Sato   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

(2010) Jing Ye et al.   CELL

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice

(2010) Cuiying Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional dissection of SIRT6: Identification of domains that regulate histone deacetylase activity and chromatin localization

(2010) Ruth I. Tennen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

(2010) Wei Fan et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C

(2010) M. Ming et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin regulation and genome maintenance by mammalian SIRT6

(2010) Ruth I. Tennen et al.   TRENDS IN BIOCHEMICAL SCIENCES

SIRT6 protects against pathological damage caused by diet-induced obesity

(2009) Yariv Kanfi et al.   AGING CELL

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

Histone H3 Lysine 56 Acetylation Is Linked to the Core Transcriptional Network in Human Embryonic Stem Cells

(2009) Wei Xie et al.   MOLECULAR CELL

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

(2009) Frédéric Van Gool et al.   NATURE MEDICINE

The impact of retrotransposons on human genome evolution

(2009) Richard Cordaux et al.   NATURE REVIEWS GENETICS

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

Epigenetic Control of rDNA Loci in Response to Intracellular Energy Status

(2008) Akiko Murayama et al.   CELL

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

Cellular Dysfunction in Sepsis

(2008) Mervyn Singer   CLINICS IN CHEST MEDICINE

Regulation of SIRT6 protein levels by nutrient availability

(2008) Yariv Kanfi et al.   FEBS LETTERS

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis

(2008) Rui-Hong Wang et al.   MOLECULAR CELL

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase/Visfatin Enzymatic Activity Identifies a New Inflammatory Pathway Linked to NAD

(2008) Nathalie Busso et al.   PLoS One

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA