A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity

The Histone Deacetylase SIRT6: At the Crossroads Between Epigenetics, Metabolism and Disease

(2015) Jean-Pierre Etchegaray et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

SIRT6, a protein with many faces

(2013) Asaf A. Gertler et al.   BIOGERONTOLOGY

A miR-34a-SIRT6 axis in the squamous cell differentiation network

(2013) Karine Lefort et al.   EMBO JOURNAL

The Role of SIRT6 Protein in Aging and Reprogramming of Human Induced Pluripotent Stem Cells

(2013) Amit Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence

(2013) N. Takasaka et al.   JOURNAL OF IMMUNOLOGY

SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling

(2013) Debra Toiber et al.   MOLECULAR CELL

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation

(2013) Zhenghong Lin et al.   Cell Reports

SIRT6 Puts Cancer Metabolism in the Driver’s Seat

(2012) Costas A. Lyssiotis et al.   CELL

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis

(2012) John E. Dominy et al.   MOLECULAR CELL

Metabolism in 'the driver's seat

(2012) Luisa Tasselli et al.   NATURE

Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin

(2012) Lihua Min et al.   NATURE CELL BIOLOGY

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

(2012) Nagalingam R Sundaresan et al.   NATURE MEDICINE

Are sirtuins viable targets for improving healthspan and lifespan?

(2012) Joseph A. Baur et al.   NATURE REVIEWS DRUG DISCOVERY

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation

(2012) Peter Kolesar et al.   NUCLEIC ACIDS RESEARCH

Sub-cellular localization, expression and functions of Sirt6 during the cell cycle in HeLa cells

(2012) Pooneh Memar Ardestani et al.   Nucleus

Characterizing the N- and C-terminal Small Ubiquitin-like Modifier (SUMO)-interacting Motifs of the Scaffold Protein DAXX

(2011) Eric Escobar-Cabrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

(2011) A. Davalos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks

(2011) Tiara L. A. Kawahara et al.   PLoS Genetics

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

SIRT6 in DNA repair, metabolism and ageing

(2010) D. B. Lombard et al.   JOURNAL OF INTERNAL MEDICINE

Functional dissection of SIRT6: Identification of domains that regulate histone deacetylase activity and chromatin localization

(2010) Ruth I. Tennen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

SUMO-Specific Protease 2 Is Essential for Suppression of Polycomb Group Protein-Mediated Gene Silencing during Embryonic Development

(2010) Xunlei Kang et al.   MOLECULAR CELL

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation

(2010) Abderrahmane Kaidi et al.   SCIENCE

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

SUMOylation and De-SUMOylation: Wrestling with Life's Processes

(2008) Edward T. H. Yeh   JOURNAL OF BIOLOGICAL CHEMISTRY