SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC
出版年份 2016 全文链接
标题
SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC
作者
关键词
Hepatocellular carcinoma, DNA damage, Histones, Cell cycle and cell division, Mutation databases, Carcinogenesis, Microarrays, Mouse models
出版物
PLoS One
Volume 11, Issue 11, Pages e0165835
出版商
Public Library of Science (PLoS)
发表日期
2016-11-09
DOI
10.1371/journal.pone.0165835
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Sirtuins at the Breaking Point: SIRT6 in DNA Repair
- (2016) David B. Lombard Aging-US
- SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair
- (2016) Ronald A. McCord et al. Aging-US
- Depletion of nuclear histone H2A variants is associated with chronic DNA damage signaling upon drug-evoked senescence of human somatic cells
- (2016) Mary F. Lopez et al. Aging-US
- Sirtuin 6 promotes transforming growth factor-β1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence
- (2015) Xin-Xia Feng et al. CANCER SCIENCE
- Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics
- (2015) Giovanna Sociali et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes
- (2015) K. Nagai et al. OSTEOARTHRITIS AND CARTILAGE
- Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer
- (2015) Sita Kugel et al. Cell Reports
- The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer
- (2014) Da Wang et al. DNA AND CELL BIOLOGY
- Senescence and apoptosis: dueling or complementary cell fates?
- (2014) B. G. Childs et al. EMBO REPORTS
- Genomic portrait of resectable hepatocellular carcinomas: Implications ofRB1andFGF19aberrations for patient stratification
- (2014) Sung-Min Ahn et al. HEPATOLOGY
- Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging
- (2014) Namgyu Lee et al. PROTEOMICS
- MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer
- (2014) U. Thirumurthi et al. Science Signaling
- SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer
- (2013) Mattaka Khongkow et al. CARCINOGENESIS
- Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients
- (2013) Jens U. Marquardt et al. HEPATOLOGY
- Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence
- (2013) N. Takasaka et al. JOURNAL OF IMMUNOLOGY
- SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence
- (2012) Anna Cardus et al. CARDIOVASCULAR RESEARCH
- The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
- (2012) Carlos Sebastián et al. CELL
- Assessing Cell and Organ Senescence Biomarkers
- (2012) Bruno Bernardes de Jesus et al. CIRCULATION RESEARCH
- The NAD+-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca2+Responses
- (2012) Inga Bauer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging
- (2012) Gaoxiang Jia et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin
- (2012) Lihua Min et al. NATURE CELL BIOLOGY
- Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
- (2012) Akihiro Fujimoto et al. NATURE GENETICS
- Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
- (2012) Z. Mao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SIRT6 Promotes DNA Repair Under Stress by Activating PARP1
- (2011) Z. Mao et al. SCIENCE
- Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells
- (2010) Shunsuke Minagawa et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Overexpression of High-Mobility Group Box 2 Is Associated with Tumor Aggressiveness and Prognosis of Hepatocellular Carcinoma
- (2010) J.-H. Kwon et al. CLINICAL CANCER RESEARCH
- Chromatin structure as a mediator of aging
- (2010) Jason Feser et al. FEBS LETTERS
- SIRT6 in DNA repair, metabolism and ageing
- (2010) D. B. Lombard et al. JOURNAL OF INTERNAL MEDICINE
- Elevated Histone Expression Promotes Life Span Extension
- (2010) Jason Feser et al. MOLECULAR CELL
- An age of fewer histones
- (2010) Philipp Oberdoerffer NATURE CELL BIOLOGY
- Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation
- (2010) Abderrahmane Kaidi et al. SCIENCE
- SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span
- (2009) Tiara L.A. Kawahara et al. CELL
- The DNA-damage response in human biology and disease
- (2009) Stephen P. Jackson et al. NATURE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started