Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses

(2019) Ivana Kurelac et al.   Nature Communications

Role of Mitochondria in the Mechanism(s) of Action of Metformin

(2019) Guillaume Vial et al.   Frontiers in Endocrinology

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

(2019) Mengqi Li et al.   Cell Metabolism

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

Unraveling the Complex Interplay Between T Cell Metabolism and Function

(2018) Ramon I. Klein Geltink et al.   Annual Review of Immunology

Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer

(2018) Lifeng Li et al.   CANCER RESEARCH

Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway

(2018) Paige V. Bauer et al.   Cell Metabolism

Alkannin Inhibited Hepatic Inflammation in Diabetic Db/Db Mice

(2018) Wenhua Xue et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid CancerIn VitroandIn Vivo

(2018) Shilpa Thakur et al.   CLINICAL CANCER RESEARCH

Pharmacokinetics of metformin in patients with gastrointestinal intolerance

(2018) Laura J. McCreight et al.   DIABETES OBESITY & METABOLISM

Effect of metformin on glycaemic control in patients with type 1 diabetes: A meta-analysis of randomized controlled trials

(2018) Haiyang Meng et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Metformin improves obesity-associated inflammation by altering macrophages polarization

(2018) Yuanyuan Jing et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype

(2018) Zhao Yan et al.   MOLECULAR MEDICINE

Metformin reverses established lung fibrosis in a bleomycin model

(2018) Sunad Rangarajan et al.   NATURE MEDICINE

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

(2018) Anila K. Madiraju et al.   NATURE MEDICINE

Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment

(2018) Héctor F. Escobar-Morreale   Nature Reviews Endocrinology

Structural Alteration of Gut Microbiota during the Amelioration of Human Type 2 Diabetes with Hyperlipidemia by Metformin and a Traditional Chinese Herbal Formula: a Multicenter, Randomized, Open Label Clinical Trial

(2018) Xiaolin Tong et al.   mBio

Understanding the Representative Gut Microbiota Dysbiosis in Metformin-Treated Type 2 Diabetes Patients Using Genome-Scale Metabolic Modeling

(2018) Dorines Rosario et al.   Frontiers in Physiology

The Therapeutic Potential of Metformin in Neurodegenerative Diseases

(2018) Carola Rotermund et al.   Frontiers in Endocrinology

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development

(2018) Nadia Boudaba et al.   EBioMedicine

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

(2018) Ryan M. Esquejo et al.   EBioMedicine

Extensive impact of non-antibiotic drugs on human gut bacteria

(2018) Lisa Maier et al.   NATURE

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

(2018) Roger W. Hunter et al.   NATURE MEDICINE

The metabolic role of vagal afferent innervation

(2018) T. M. Zaved Waise et al.   Nature Reviews Gastroenterology & Hepatology

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers

(2018) Ilze Elbere et al.   PLoS One

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

(2018) Jamie N. Justice et al.   GeroScience

Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

(2018) Melanie J. Davies et al.   DIABETES CARE

Comparative effects of proximal and distal small intestinal administration of metformin on plasma glucose and glucagon-like peptide-1, and gastric emptying after oral glucose, in type 2 diabetes

(2018) Malcolm J. Borg et al.   DIABETES OBESITY & METABOLISM

Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

(2018) Melanie J. Davies et al.   DIABETOLOGIA

Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism

(2018) Ahmed Alshawi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

Metformin-Induced Mitochondrial Complex I Inhibition: Facts, Uncertainties, and Consequences

(2018) Eric Fontaine   Frontiers in Endocrinology

Homeostatic Immunity and the Microbiota

(2017) Yasmine Belkaid et al.   IMMUNITY

Single-Dose Metformin Enhances Bile Acid–Induced Glucagon-Like Peptide-1 Secretion in Patients With Type 2 Diabetes

(2017) Andreas Brønden et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metformin Suppresses Systemic Autoimmunity inRoquinsan/sanMice through Inhibiting B Cell Differentiation into Plasma Cells via Regulation of AMPK/mTOR/STAT3

(2017) Seon-Yeong Lee et al.   JOURNAL OF IMMUNOLOGY

Transporters Involved in Metformin Pharmacokinetics and Treatment Response

(2017) Xiaomin Liang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

(2017) Hao Wu et al.   NATURE MEDICINE

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial

(2017) John R Petrie et al.   Lancet Diabetes & Endocrinology

Effect of artificial pancreas systems on glycaemic control in patients with type 1 diabetes: a systematic review and meta-analysis of outpatient randomised controlled trials

(2017) Alanna Weisman et al.   Lancet Diabetes & Endocrinology

Attenuation of CD4 + CD25 + Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

(2017) Yuki Kunisada et al.   EBioMedicine

Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes

(2016) Nisa M. Maruthur et al.   ANNALS OF INTERNAL MEDICINE

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase

(2016) Hannah R. Bridges et al.   BMC BIOLOGY

Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells

(2016) Gang Cheng et al.   CANCER RESEARCH

Metformin Activates AMPK through the Lysosomal Pathway

(2016) Chen-Song Zhang et al.   Cell Metabolism

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

(2016) Dan Y. Gui et al.   Cell Metabolism

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance

(2016) Amy R. Cameron et al.   CIRCULATION RESEARCH

[11C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice Demonstrates Tissue-Specific Transporter Dependency

(2016) Jonas B. Jensen et al.   DIABETES

Metformin Is Associated With Higher Relative Abundance of Mucin-DegradingAkkermansia muciniphilaand Several Short-Chain Fatty Acid–Producing Microbiota in the Gut

(2016) Jacobo de la Cuesta-Zuluaga et al.   DIABETES CARE

Comment on Kazda et al. Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies. Diabetes Care 2016;39:1241–1249

(2016) Sweety Agrawal et al.   DIABETES CARE

Effect of Serotonin Transporter 5-HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study

(2016) Tanja Dujic et al.   DIABETES CARE

Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes

(2016) Tongzhi Wu et al.   DIABETES OBESITY & METABOLISM

Involvement of glucagon-like peptide-1 in the glucose-lowering effect of metformin

(2016) Emilie Bahne et al.   DIABETES OBESITY & METABOLISM

Effect of chenodeoxycholic acid and the bile acid sequestrant colesevelam on glucagon-like peptide-1 secretion

(2016) M. Hansen et al.   DIABETES OBESITY & METABOLISM

Once-daily delayed-release metformin lowers plasma glucose and enhances fasting and postprandial GLP-1 and PYY: results from two randomised trials

(2016) Ralph A. DeFronzo et al.   DIABETOLOGIA

Metformin and the gastrointestinal tract

(2016) Laura J. McCreight et al.   DIABETOLOGIA

Additional effect of metformin and celecoxib against lipid dysregulation and adipose tissue inflammation in high-fat fed rats with insulin resistance and fatty liver

(2016) Chieh-Hua Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Will delayed release metformin provide better management of diabetes type 2?

(2016) André J. Scheen   EXPERT OPINION ON PHARMACOTHERAPY

The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance

(2016) Adam H. Balen et al.   HUMAN REPRODUCTION UPDATE

Comparison of Clinical Outcomes and Adverse Events Associated With Glucose-Lowering Drugs in Patients With Type 2 Diabetes

(2016) Suetonia C. Palmer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

In Vivo Imaging of Human 11C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses

(2016) L. C. Gormsen et al.   JOURNAL OF NUCLEAR MEDICINE

Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer

(2016) Stepana Boukalova et al.   MOLECULAR CANCER THERAPEUTICS

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

(2016) Kaixin Zhou et al.   NATURE GENETICS

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

New insights into the anti-diabetic actions of metformin: from the liver to the gut

(2016) Tongzhi Wu et al.   Expert Review of Gastroenterology & Hepatology

Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis

(2016) Laura Negrotto et al.   JAMA Neurology

Immune Regulation of Metabolic Homeostasis in Health and Disease

(2015) Jonathan R. Brestoff et al.   CELL

Glucoregulatory Relevance of Small Intestinal Nutrient Sensing in Physiology, Bariatric Surgery, and Pharmacology

(2015) Frank A. Duca et al.   Cell Metabolism

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis

(2015) John D. Clarke et al.   DIABETES

Inhibition of the multidrug and toxin extrusion (MATE) transporter by pyrimethamine increases the plasma concentration of metformin but does not increase antihyperglycaemic activity in humans

(2015) J. Oh et al.   DIABETES OBESITY & METABOLISM

Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

(2015) Meltem Cetin et al.   DRUG DELIVERY

Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis

(2015) Negar Naderpoor et al.   HUMAN REPRODUCTION UPDATE

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages

(2015) Beth Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin as a potential combination therapy with existing front-line antibiotics for Tuberculosis

(2015) Rohit Vashisht et al.   Journal of Translational Medicine

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network

(2015) Clémence D Côté et al.   NATURE MEDICINE

Metformin activates a duodenal Ampk–dependent pathway to lower hepatic glucose production in rats

(2015) Frank A Duca et al.   NATURE MEDICINE

Regulation of metabolism by the innate immune system

(2015) Denise E. Lackey et al.   Nature Reviews Endocrinology

Immune-mediated antitumor effect by type 2 diabetes drug, metformin

(2015) Shingo Eikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic insight from the crystal structure of mitochondrial complex I

(2015) V. Zickermann et al.   SCIENCE

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

(2015) Mohamed-Sami Trabelsi et al.   Nature Communications

Metformin Inhibits Monocyte-to-Macrophage Differentiation via AMPK-Mediated Inhibition of STAT3 Activation: Potential Role in Atherosclerosis

(2015) Sathish Babu Vasamsetti et al.   DIABETES

Effect of Metformin on Metabolic Improvement and Gut Microbiota

(2014) Heetae Lee et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Metformin and respiratory chain complex I: the last piece of the puzzle?

(2014) Eric Fontaine   BIOCHEMICAL JOURNAL

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Control of Gluconeogenesis by Metformin: Does Redox Trump Energy Charge?

(2014) Joseph A. Baur et al.   Cell Metabolism

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine

(2014) Rune E. Kuhre et al.   DIABETES

Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study

(2014) Tanja Dujic et al.   DIABETES

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)

(2014) Jia Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin Suppresses Lipopolysaccharide (LPS)-induced Inflammatory Response in Murine Macrophages via Activating Transcription Factor-3 (ATF-3) Induction

(2014) Juyoung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk

(2014) Fleur Lien et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

An update on the pharmacogenomics of metformin: progress, problems and potential

(2014) Jennifer N Todd et al.   PHARMACOGENOMICS

Metformin affects macrophages’ phenotype and improves the activity of glutathione peroxidase, superoxide dismutase, catalase and decreases malondialdehyde concentration in a partially AMPK-independent manner in LPS-stimulated human monocytes/macrophages

(2014) Łukasz Bułdak et al.   Pharmacological Reports

Metformin as adjunct antituberculosis therapy

(2014) A. Singhal et al.   Science Translational Medicine

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

Mitochondrial Complex I

(2013) Judy Hirst   Annual Review of Biochemistry

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response

(2013) V. E. Zannella et al.   CLINICAL CANCER RESEARCH

Most Youth With Type 1 Diabetes in the T1D Exchange Clinic Registry Do Not Meet American Diabetes Association or International Society for Pediatric and Adolescent Diabetes Clinical Guidelines

(2013) J. R. Wood et al.   DIABETES CARE

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

Metformin enhances glucagon-like peptide 1 via cooperation between insulin and Wnt signaling

(2013) Mi-Hyun Kim et al.   JOURNAL OF ENDOCRINOLOGY

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel cobiotic containing a prebiotic and an antioxidant augments the glucose control and gastrointestinal tolerability of metformin: a case report

(2013) F. Greenway et al.   Beneficial Microbes

Cellular Responses to the Metal-Binding Properties of Metformin

(2012) L. Logie et al.   DIABETES

Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans

(2012) T. Wu et al.   DIABETES OBESITY & METABOLISM

Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion

(2012) H. E. Parker et al.   DIABETOLOGIA

Direct control of hepatic glucose production by interleukin-13 in mice

(2012) Kristopher J. Stanya et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells

(2012) Camilla Kappe et al.   JOURNAL OF GASTROENTEROLOGY

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

The effects of rosiglitazone and metformin on inflammation and endothelial dysfunction in patients with type 2 diabetes mellitus

(2011) Evren Fidan et al.   ACTA DIABETOLOGICA

Metformin slows down aging and extends life span of female SHR mice

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

Establishment of a Database of Metformin Plasma Concentrations and Erythrocyte Levels in Normal and Emergency Situations

(2011) Jean-Daniel Lalau et al.   CLINICAL DRUG INVESTIGATION

Clinical Pharmacokinetics of Metformin

(2011) Garry G. Graham et al.   CLINICAL PHARMACOKINETICS

GLUT2 Accumulation in Enterocyte Apical and Intracellular Membranes: A Study in Morbidly Obese Human Subjects and ob/ob and High Fat-Fed Mice

(2011) A. Ait-Omar et al.   DIABETES

Metformin and digestive disorders

(2011) M. Bouchoucha et al.   DIABETES & METABOLISM

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

(2011) X. Stephenne et al.   DIABETOLOGIA

Mechanisms Underlying Metformin-Induced Secretion of Glucagon-Like Peptide-1 from the Intestinal L Cell

(2011) Andrew J. Mulherin et al.   ENDOCRINOLOGY

The Role of Metformin in the Management of NAFLD

(2011) Angela Mazza et al.   Experimental Diabetes Research

The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c

(2011) Mette M.H. Christensen et al.   Pharmacogenetics and Genomics

Neuroendocrine dysfunction in polycystic ovary syndrome

(2011) Christine M. Burt Solorzano et al.   STEROIDS

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

Common Variants in 40 Genes Assessed for Diabetes Incidence and Response to Metformin and Lifestyle Intervention in the Diabetes Prevention Program

(2010) K. A. Jablonski et al.   DIABETES

Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice

(2010) A. Maida et al.   DIABETOLOGIA

Insulin enhances ACTH-stimulated androgen and glucocorticoid metabolism in hyperandrogenic women

(2010) Flavia Tosi et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

AMPK-dependent Repression of Hepatic Gluconeogenesis via Disruption of CREB·CRTC2 Complex by Orphan Nuclear Receptor Small Heterodimer Partner

(2010) Ji-Min Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with the Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society

(2010) Robert A. Wild et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5

(2010) Paul W Caton et al.   JOURNAL OF ENDOCRINOLOGY

Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

(2010) Y. Ilan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity

(2010) R. R. Ricardo-Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal

(2009) Patrice D Cani et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Kupffer cell activation is a causal factor for hepatic insulin resistance

(2009) Nicolas Lanthier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

(2009) Ling He et al.   CELL

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) W. Huang et al.   DIABETES

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Metformin and the intestine

(2008) C. J. Bailey et al.   DIABETOLOGIA