Metformin activates a duodenal Ampk–dependent pathway to lower hepatic glucose production in rats

AMPK in the Small Intestine in Normal and Pathophysiological Conditions

(2014) Elodie Harmel et al.   ENDOCRINOLOGY

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment

(2014) Michael Pollak   NATURE MEDICINE

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

(2013) David B. Shackelford et al.   CANCER CELL

Jejunal Leptin-PI3K Signaling Lowers Glucose Production

(2013) Brittany A. Rasmussen et al.   Cell Metabolism

Effects of Sitagliptin and Metformin Treatment on Incretin Hormone and Insulin Secretory Responses to Oral and "Isoglycemic" Intravenous Glucose

(2013) I. Vardarli et al.   DIABETES

Identification and Characterization of GLP-1 Receptor-Expressing Cells Using a New Transgenic Mouse Model

(2013) P. Richards et al.   DIABETES

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and Inhibiting Its Activity

(2013) G. He et al.   MOLECULAR AND CELLULAR BIOLOGY

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Insulin Activates Erk1/2 Signaling in the Dorsal Vagal Complex to Inhibit Glucose Production

(2012) Beatrice M. Filippi et al.   Cell Metabolism

Overlap of Endocrine Hormone Expression in the Mouse Intestine Revealed by Transcriptional Profiling and Flow Cytometry

(2012) Abdella M. Habib et al.   ENDOCRINOLOGY

Duodenal Activation of cAMP-Dependent Protein Kinase Induces Vagal Afferent Firing and Lowers Glucose Production in Rats

(2012) Brittany A. Rasmussen et al.   GASTROENTEROLOGY

Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes

(2012) Danna M Breen et al.   NATURE MEDICINE

Clinical Pharmacokinetics of Metformin

(2011) Garry G. Graham et al.   CLINICAL PHARMACOKINETICS

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Mechanisms Underlying Metformin-Induced Secretion of Glucagon-Like Peptide-1 from the Intestinal L Cell

(2011) Andrew J. Mulherin et al.   ENDOCRINOLOGY

Duodenal Mucosal Protein Kinase C-δ Regulates Glucose Production in Rats

(2011) Andrea Kokorovic et al.   GASTROENTEROLOGY

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice

(2010) A. Maida et al.   DIABETOLOGIA

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuronal regulation of homeostasis by nutrient sensing

(2010) Tony K T Lam   NATURE MEDICINE

Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network

(2009) Grace W.C. Cheung et al.   Cell Metabolism

Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes

(2009) V. T. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-analysis: Metformin Treatment in Persons at Risk for Diabetes Mellitus

(2008) Shelley R. Salpeter et al.   AMERICAN JOURNAL OF MEDICINE

Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production

(2008) Penny Y. T. Wang et al.   NATURE