Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)

Potential biomarker of metformin action

(2014) Ling He et al.   JOURNAL OF ENDOCRINOLOGY

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Activation of Basal Gluconeogenesis by Coactivator p300 Maintains Hepatic Glycogen Storage

(2013) Ling He et al.   MOLECULAR ENDOCRINOLOGY

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake

(2012) Yossi Dagon et al.   Cell Metabolism

The Effect of Novel Promoter Variants in MATE1 and MATE2 on the Pharmacokinetics and Pharmacodynamics of Metformin

(2012) S L Stocker et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway

(2012) Luisa Garcia-Haro et al.   FEBS LETTERS

Short-term treatment with metformin suppresses toll like receptors (TLRs) activity in isoproterenol-induced myocardial infarction in rat: Are AMPK and TLRs connected?

(2012) Hamid Soraya et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Transcriptional Co-activator p300 Maintains Basal Hepatic Gluconeogenesis

(2012) Ling He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

5′-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes

(2011) Yugo Tsuchiya et al.   BIOSCIENCE REPORTS

Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration

(2011) S. Larsen et al.   DIABETOLOGIA

Suppression of AMPK Activation via S485 Phosphorylation by IGF-I during Hyperglycemia Is Mediated by AKT Activation in Vascular Smooth Muscle Cells

(2011) Junyu Ning et al.   ENDOCRINOLOGY

Adrenergic Regulation of AMP-activated Protein Kinase in Brown Adipose Tissuein Vivo

(2011) Thomas Pulinilkunnil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

Role of KLF15 in Regulation of Hepatic Gluconeogenesis and Metformin Action

(2010) M. Takashima et al.   DIABETES

Increased Expression of Hepatic Organic Cation Transporter 1 and Hepatic Distribution of Metformin in High-fat Diet-induced Obese Mice

(2010) Eun-Hee Jang et al.   Drug Metabolism and Pharmacokinetics

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

(2009) Ling He et al.   CELL

New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

(2009) G. Libby et al.   DIABETES CARE

Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes: ZODIAC-16

(2009) G. W.D. Landman et al.   DIABETES CARE

PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis

(2009) Nabil Djouder et al.   EMBO JOURNAL

Antidiabetic Therapies Affect Risk of Pancreatic Cancer

(2009) Donghui Li et al.   GASTROENTEROLOGY