Metformin-Induced Mitochondrial Complex I Inhibition: Facts, Uncertainties, and Consequences

SIRT3 aggravates metformin-induced energy stress and apoptosis in ovarian cancer cells

(2018) Yao Wu et al.   EXPERIMENTAL CELL RESEARCH

Metformin selectively targets redox control of complex I energy transduction

(2018) Amy R. Cameron et al.   Redox Biology

The Therapeutic Potential of Metformin in Neurodegenerative Diseases

(2018) Carola Rotermund et al.   Frontiers in Endocrinology

Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation

(2018) Kathleen A. Boyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanisms of Metformin for Diabetes and Cancer Treatment

(2018) Min Li et al.   Frontiers in Physiology

Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activation

(2017) Wo-Lin Hou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains

(2017) Evelina Rekuviene et al.   NEUROSCIENCE LETTERS

Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I

(2017) Sunbin Ling et al.   Cell Death & Disease

Metformin attenuates myocardial ischemia-reperfusion injury via up-regulation of antioxidant enzymes

(2017) Xiaoling Wang et al.   PLoS One

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells

(2017) Camille Loubiere et al.   Scientific Reports

Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells

(2016) Gang Cheng et al.   CANCER RESEARCH

[11C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice Demonstrates Tissue-Specific Transporter Dependency

(2016) Jonas B. Jensen et al.   DIABETES

Rotenone induces apoptosis in human lung cancer cells by regulating autophagic flux

(2016) Wensi Hu et al.   IUBMB LIFE

Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer

(2016) Stepana Boukalova et al.   MOLECULAR CANCER THERAPEUTICS

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

(2016) Deheng Chen et al.   Cell Death & Disease

Anti-tumor activity of metformin: from metabolic and epigenetic perspectives

(2016) Xilan Yu et al.   Oncotarget

Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation

(2015) Monika Cahova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Selective Inhibition of Deactivated Mitochondrial Complex I by Biguanides

(2015) Satoshi Matsuzaki et al.   BIOCHEMISTRY

Respective effects of oxygen and energy substrate deprivation on beta cell viability

(2015) Sandrine Lablanche et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Transient complex I inhibition at the onset of reperfusion by extracellular acidification decreases cardiac injury

(2014) Aijun Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Metformin mitigates apoptosis in ischemic myocardium

(2014) Nassrene Y. Elmadhun et al.   JOURNAL OF SURGICAL RESEARCH

Metformin Impairs Mitochondrial Function in Skeletal Muscle of Both Lean and Diabetic Rats in a Dose-Dependent Manner

(2014) Bart Wessels et al.   PLoS One

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Diabetes, pancreatic cancer, and metformin therapy

(2014) Jun Gong et al.   Frontiers in Physiology

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D

(2012) Bo Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Permeability Transition Pore Inhibitors Prevent Ethanol-Induced Neuronal Death in Mice

(2012) Frederic Lamarche et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metformin Inhibits Human Androgen Production by Regulating Steroidogenic Enzymes HSD3B2 and CYP17A1 and Complex I Activity of the Respiratory Chain

(2012) Andrea Hirsch et al.   ENDOCRINOLOGY

Prerequisites for ubiquinone analogs to prevent mitochondrial permeability transition-induced cell death

(2012) Julie Belliere et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Cationic Amphiphilic Drugs Cause a Marked Expansion of Apparent Lysosomal Volume: Implications for an Intracellular Distribution-Based Drug Interaction

(2012) Ryan S. Funk et al.   MOLECULAR PHARMACEUTICS

Metformin pathways

(2012) Li Gong et al.   Pharmacogenetics and Genomics

Mitochondrial permeability transition in Ca2+-dependent apoptosis and necrosis

(2011) Andrea Rasola et al.   CELL CALCIUM

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

(2011) X. Stephenne et al.   DIABETOLOGIA

The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c

(2011) Mette M.H. Christensen et al.   Pharmacogenetics and Genomics

Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin

(2011) S Lablanche et al.   Cell Death & Disease

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway

(2010) Ana I. Morales et al.   KIDNEY INTERNATIONAL

Ubiquinone Analogs: A Mitochondrial Permeability Transition Pore-Dependent Pathway to Selective Cell Death

(2010) Flavien Devun et al.   PLoS One

Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study

(2009) K. Zhou et al.   DIABETES

Effect of Transient and Permanent Permeability Transition Pore Opening on NAD(P)H Localization in Intact Cells

(2009) Jean François Dumas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling

(2009) Yea-Tzy Deng et al.   MOLECULAR CARCINOGENESIS

Targeted Disruption of the Multidrug and Toxin Extrusion 1 (Mate1) Gene in Mice Reduces Renal Secretion of Metformin

(2009) M. Tsuda et al.   MOLECULAR PHARMACOLOGY

Complex I within Oxidatively Stressed Bovine Heart Mitochondria Is Glutathionylated on Cys-531 and Cys-704 of the 75-kDa Subunit

(2008) Thomas R. Hurd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the Mitochondrial ND3 Subunit as a Structural Component Involved in the Active/Deactive Enzyme Transition of Respiratory Complex I

(2008) Alexander Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

(2008) James A. Dykens et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY