Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals?
出版年份 2019 全文链接
标题
Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals?
作者
关键词
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出版物
MOVEMENT DISORDERS
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2019-09-05
DOI
10.1002/mds.27823
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration
- (2019) Danielle E. Mor et al. MOVEMENT DISORDERS
- Regulation and Function of Mitochondria–Lysosome Membrane Contact Sites in Cellular Homeostasis
- (2019) Yvette C. Wong et al. TRENDS IN CELL BIOLOGY
- Parkinson’s disease-linkedD620N VPS35knockin mice manifest tau neuropathology and dopaminergic neurodegeneration
- (2019) Xi Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease
- (2019) Sara Bandres-Ciga et al. MOVEMENT DISORDERS
- Relationship between neuromelanin and dopamine terminals within the Parkinson’s nigrostriatal system
- (2019) Antonio Martín-Bastida et al. BRAIN
- Dopaminergic Vulnerability in Parkinson Disease: The Cost of Humans’ Habitual Performance
- (2019) Ledia F. Hernandez et al. TRENDS IN NEUROSCIENCES
- Blood–brain barrier opening with focused ultrasound in experimental models of Parkinson's disease
- (2019) Maria Eleni Karakatsani et al. MOVEMENT DISORDERS
- Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity
- (2018) Esteban Luna et al. ACTA NEUROPATHOLOGICA
- Critical appraisal of pathology transmission in the α-synuclein fibril model of Lewy body disorders
- (2018) Negin Nouraei et al. EXPERIMENTAL NEUROLOGY
- Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function
- (2018) Myung Jong Kim et al. HUMAN MOLECULAR GENETICS
- Comparative analysis of Parkinson's disease–associated genes in mice reveals altered survival and bioenergetics of Parkin-deficient dopamine neurons
- (2018) Nicolas Giguère et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The metabolic pattern of idiopathic REM sleep behavior disorder reflects early-stage Parkinson’s disease
- (2018) Sanne Katherina Meles et al. JOURNAL OF NUCLEAR MEDICINE
- Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis
- (2018) Yvette C. Wong et al. NATURE
- Crosstalk between presynaptic trafficking and autophagy in Parkinson's disease
- (2018) Ping-Yue Pan et al. NEUROBIOLOGY OF DISEASE
- Deregulation of autophagy and vesicle trafficking in Parkinson’s disease
- (2018) Patricia Sheehan et al. NEUROSCIENCE LETTERS
- LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease
- (2018) Maria Nguyen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson's Disease
- (2018) Nicolas Giguère et al. Frontiers in Neurology
- α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons
- (2018) Jessica M. Froula et al. Acta Neuropathologica Communications
- Parkinson's disease: convergence on synaptic homeostasis
- (2018) Sandra‐Fausia Soukup et al. EMBO JOURNAL
- Morphology of mitochondria in spatially restricted axons revealed by cryo-electron tomography
- (2018) Tara D. Fischer et al. PLOS BIOLOGY
- Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment
- (2018) Ayami Okuzumi et al. Acta Neuropathologica Communications
- Glucocerebrosidase mutations and synucleinopathies: Toward a model of precision medicine
- (2018) Fabio Blandini et al. MOVEMENT DISORDERS
- Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson’s Disease
- (2018) Maria Nguyen et al. TRENDS IN NEUROSCIENCES
- Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress
- (2017) Han Shi et al. HUMAN MOLECULAR GENETICS
- Limited distal organelles and synaptic function in extensive monoaminergic innervation
- (2017) Juan Tao et al. JOURNAL OF CELL SCIENCE
- Differential Presynaptic ATP Supply for Basal and High-Demand Transmission
- (2017) Courtney Sobieski et al. JOURNAL OF NEUROSCIENCE
- Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons
- (2017) Ping-Yue Pan et al. JOURNAL OF NEUROSCIENCE
- Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy
- (2017) J.A. Obeso et al. MOVEMENT DISORDERS
- A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
- (2017) Diana Chang et al. NATURE GENETICS
- α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
- (2017) Yvette C Wong et al. NATURE MEDICINE
- Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant α-synuclein rat model of parkinsonism
- (2017) Jacqueline A. Gleave et al. NEUROBIOLOGY OF DISEASE
- The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas
- (2017) Joseph R. Ecker et al. NEURON
- Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons
- (2017) Mian Cao et al. NEURON
- Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture
- (2017) Thomas Misgeld et al. NEURON
- Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease
- (2017) Amy R. Dunn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
- (2017) Lena F. Burbulla et al. SCIENCE
- The Mesoaccumbens Pathway: A Retrograde Labeling and Single-Cell Axon Tracing Analysis in the Mouse
- (2017) Claudia Rodríguez-López et al. Frontiers in Neuroanatomy
- Synucleins Have Multiple Effects on Presynaptic Architecture
- (2017) Karina J. Vargas et al. Cell Reports
- Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice
- (2017) Mattia Volta et al. eLife
- Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence
- (2016) Joseph R. Mazzulli et al. ANALYTICAL CHEMISTRY
- D NAJC 6 Mutations Associated With Early-Onset Parkinson's Disease
- (2016) Simone Olgiati et al. ANNALS OF NEUROLOGY
- Arf6 and the 5'phosphatase of synaptojanin 1 regulate autophagy in cone photoreceptors
- (2016) Ashley A. George et al. BIOESSAYS
- Comprehensive cellular-resolution atlas of the adult human brain
- (2016) Song-Lin Ding et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation
- (2016) B. A. Matikainen-Ankney et al. JOURNAL OF NEUROSCIENCE
- Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology
- (2016) David H. Adamowicz et al. JOURNAL OF NEUROSCIENCE
- Compartment-Specific Regulation of Autophagy in Primary Neurons
- (2016) Sandra Maday et al. JOURNAL OF NEUROSCIENCE
- G2019S-LRRK2 Expression Augments -Synuclein Sequestration into Inclusions in Neurons
- (2016) L. A. Volpicelli-Daley et al. JOURNAL OF NEUROSCIENCE
- Salivary gland biopsy for diagnosis of Parkinson's disease?
- (2016) A Jon Stoessl LANCET NEUROLOGY
- LRRK2 at the interface of autophagosomes, endosomes and lysosomes
- (2016) Dorien A. Roosen et al. Molecular Neurodegeneration
- LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate
- (2016) Elisa Belluzzi et al. Molecular Neurodegeneration
- Lysosomal trafficking defects link Parkinson's disease with Gaucher's disease
- (2016) Yvette C. Wong et al. MOVEMENT DISORDERS
- Neuropathological basis of nonmotor manifestations of Parkinson's disease
- (2016) Charles H. Adler et al. MOVEMENT DISORDERS
- First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers
- (2016) Dale B. Schenk et al. MOVEMENT DISORDERS
- A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals
- (2016) Sandra-Fausia Soukup et al. NEURON
- α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
- (2016) Joseph R. Mazzulli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System
- (2016) John D. Murdoch et al. Cell Reports
- Hipposeq: a comprehensive RNA-seq database of gene expression in hippocampal principal neurons
- (2016) Mark S Cembrowski et al. eLife
- Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
- (2016) Martin Steger et al. eLife
- Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies
- (2016) Graham Fairfoul et al. Annals of Clinical and Translational Neurology
- Pathological α-synuclein distribution in subjects with coincident Alzheimer’s and Lewy body pathology
- (2015) Jon B. Toledo et al. ACTA NEUROPATHOLOGICA
- Skin biopsies in the differential diagnosis of parkinsonism: are we ready for simplified protocols?
- (2015) Kathrin Doppler et al. BRAIN
- Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice
- (2015) Michael Helwig et al. BRAIN
- Glucocerebrosidase activity in Parkinson’s disease with and withoutGBAmutations
- (2015) Roy N. Alcalay et al. BRAIN
- Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons
- (2015) Consiglia Pacelli et al. CURRENT BIOLOGY
- Selective expression of Parkinson's disease-relatedLeucine-rich repeat kinase 2G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression
- (2015) Guoxiang Liu et al. HUMAN MOLECULAR GENETICS
- Autophagosome dynamics in neurodegeneration at a glance
- (2015) Y. C. Wong et al. JOURNAL OF CELL SCIENCE
- Brain region-dependent differential expression of alpha-synuclein
- (2015) Katsutoshi Taguchi et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy
- (2015) Markus Mandler et al. Molecular Neurodegeneration
- Trophic factors for Parkinson's disease: To live or let die
- (2015) C. Warren Olanow et al. MOVEMENT DISORDERS
- A naturally occurring variant of the human prion protein completely prevents prion disease
- (2015) Emmanuel A. Asante et al. NATURE
- The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
- (2015) Alicia M. Pickrell et al. NEURON
- Long-range projection neurons of the mouse ventral tegmental area: a single-cell axon tracing analysis
- (2015) Ana Aransay et al. Frontiers in Neuroanatomy
- Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson’s disease
- (2014) Hélène Hall et al. BRAIN
- LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism
- (2014) A. M. Arranz et al. JOURNAL OF CELL SCIENCE
- Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum
- (2014) C. Pifl et al. JOURNAL OF NEUROSCIENCE
- Upregulation of Parkin in Endophilin Mutant Mice
- (2014) Mian Cao et al. JOURNAL OF NEUROSCIENCE
- Loss of Mitochondrial Fission Depletes Axonal Mitochondria in Midbrain Dopamine Neurons
- (2014) A. Berthet et al. JOURNAL OF NEUROSCIENCE
- Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes
- (2014) Laura A. Volpicelli-Daley et al. MOLECULAR BIOLOGY OF THE CELL
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
- (2014) Mike A Nalls et al. NATURE GENETICS
- (G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse
- (2014) Jun-Shiao Chou et al. NEUROBIOLOGY OF DISEASE
- PARK20 caused by SYNJ1 homozygous Arg258Gln mutation in a new Italian family
- (2014) Simone Olgiati et al. NEUROGENETICS
- Differential Expression of Alpha-Synuclein in Hippocampal Neurons
- (2014) Katsutoshi Taguchi et al. PLoS One
- Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo
- (2014) Kelly M. Lohr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation
- (2014) Jacqueline Burré et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease
- (2013) Jens Wagner et al. ACTA NEUROPATHOLOGICA
- Prion-like spreading of pathological α-synuclein in brain
- (2013) Masami Masuda-Suzukake et al. BRAIN
- Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease
- (2013) Jeffrey H. Kordower et al. BRAIN
- Regional vulnerability of hippocampal subfields and memory deficits in Parkinson's disease
- (2013) Joana B. Pereira et al. HIPPOCAMPUS
- Mutation in theSYNJ1Gene Associated with Autosomal Recessive, Early-Onset Parkinsonism
- (2013) Marialuisa Quadri et al. HUMAN MUTATION
- Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy
- (2013) Selcuk A. Tanik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The role ofSCARB2as susceptibility factor in Parkinson's disease
- (2013) Franziska Hopfner et al. MOVEMENT DISORDERS
- Interplay of LRRK2 with chaperone-mediated autophagy
- (2013) Samantha J Orenstein et al. NATURE NEUROSCIENCE
- The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease
- (2013) Eleftheria K. Pissadaki et al. Frontiers in Computational Neuroscience
- A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies
- (2013) Michael A. Nalls et al. JAMA Neurology
- Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains
- (2012) Matthew E. Gegg et al. ANNALS OF NEUROLOGY
- Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport
- (2012) Eric C. Freundt et al. ANNALS OF NEUROLOGY
- Alterations in axonal transport motor proteins in sporadic and experimental Parkinson’s disease
- (2012) Yaping Chu et al. BRAIN
- Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
- (2012) Sandra Maday et al. JOURNAL OF CELL BIOLOGY
- -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis
- (2012) D. Scott et al. JOURNAL OF NEUROSCIENCE
- Living on the edge with too many mouths to feed: Why dopamine neurons die
- (2012) J. Paul Bolam et al. MOVEMENT DISORDERS
- LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis
- (2012) Samer Matta et al. NEURON
- Synaptic Energy Use and Supply
- (2012) Julia J. Harris et al. NEURON
- DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability
- (2012) Çiğdem Köroğlu et al. PARKINSONISM & RELATED DISORDERS
- A Deleterious Mutation in DNAJC6 Encoding the Neuronal-Specific Clathrin-Uncoating Co-Chaperone Auxilin, Is Associated with Juvenile Parkinsonism
- (2012) Simon Edvardson et al. PLoS One
- Impaired neurotransmission caused by overexpression of -synuclein in nigral dopamine neurons
- (2012) M. Lundblad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- -Synuclein-Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons
- (2012) M. Decressac et al. Science Translational Medicine
- A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
- (2011) Alexander Zimprich et al. AMERICAN JOURNAL OF HUMAN GENETICS
- VPS35 Mutations in Parkinson Disease
- (2011) Carles Vilariño-Güell et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Longitudinal evolution of compensatory changes in striatal dopamine processing in Parkinson's disease
- (2011) Ramachandiran Nandhagopal et al. BRAIN
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
- (2011) Joseph R. Mazzulli et al. CELL
- Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons
- (2011) M. Decressac et al. NEUROBIOLOGY OF DISEASE
- Recruitment of Endophilin to Clathrin-Coated Pit Necks Is Required for Efficient Vesicle Uncoating after Fission
- (2011) Ira Milosevic et al. NEURON
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- Clinical progression in Parkinson disease and the neurobiology of axons
- (2010) Hsiao-Chun Cheng et al. ANNALS OF NEUROLOGY
- α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
- (2010) Ashley R. Winslow et al. JOURNAL OF CELL BIOLOGY
- Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S
- (2010) X. Li et al. JOURNAL OF NEUROSCIENCE
- Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial
- (2010) William J Marks et al. LANCET NEUROLOGY
- Genetic Animal Models of Parkinson's Disease
- (2010) Ted M. Dawson et al. NEURON
- Partial loss of parvalbumin-containing hippocampal interneurons in dementia with Lewy bodies
- (2010) Hans-Gert Bernstein et al. NEUROPATHOLOGY
- Distinct types of non-cholinergic pedunculopontine neurons are differentially modulated during global brain states
- (2010) H. Roš et al. NEUROSCIENCE
- Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice
- (2010) Y.-I. Yim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
- (2009) Thomas G. Beach et al. ACTA NEUROPATHOLOGICA
- Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein
- (2009) Wai Haung Yu et al. AMERICAN JOURNAL OF PATHOLOGY
- Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV -Synucleinopathy
- (2009) C. Y. Chung et al. JOURNAL OF NEUROSCIENCE
- Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum
- (2009) W. Matsuda et al. JOURNAL OF NEUROSCIENCE
- SH3 Domains from a Subset of BAR Proteins Define a Ubl-Binding Domain and Implicate Parkin in Synaptic Ubiquitination
- (2009) Jean-François Trempe et al. MOLECULAR CELL
- Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons
- (2009) Eugene V. Mosharov et al. NEURON
- Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
- (2009) E. Sidransky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Neuropathology of non-motor features of Parkinson disease
- (2009) Dennis W. Dickson et al. PARKINSONISM & RELATED DISORDERS
- Exogenous -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
- (2009) K. C. Luk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders
- (2008) Frauke Neff et al. AUTOIMMUNITY REVIEWS
- LRRK2 regulates synaptic vesicle endocytosis
- (2008) Narae Shin et al. EXPERIMENTAL CELL RESEARCH
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