The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease

Genetic risk factors in Parkinson’s disease

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Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain

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Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

(2018) Ting Qi et al.   Nature Communications

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

(2017) Diana Chang et al.   NATURE GENETICS

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

(2017) Bernard Ng et al.   NATURE NEUROSCIENCE

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson’s Disease

(2017) Li Song et al.   Cell Reports

Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations

(2017) Tianqi Wang et al.   NeuroImage-Clinical

Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank

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Autosomal-Recessive Mutations in AP3B2 , Adaptor-Related Protein Complex 3 Beta 2 Subunit, Cause an Early-Onset Epileptic Encephalopathy with Optic Atrophy

(2016) Mirna Assoum et al.   AMERICAN JOURNAL OF HUMAN GENETICS

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

(2016) Jie Zheng et al.   BIOINFORMATICS

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

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Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance

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Defects in trafficking bridge Parkinson's disease pathology and genetics

(2016) Asa Abeliovich et al.   NATURE

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Gene expression elucidates functional impact of polygenic risk for schizophrenia

(2016) Menachem Fromer et al.   NATURE NEUROSCIENCE

Genome-wide assessment of Parkinson's disease in a Southern Spanish population

(2016) Sara Bandrés-Ciga et al.   NEUROBIOLOGY OF AGING

Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia

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Breast Cancer Risk From Modifiable and Nonmodifiable Risk Factors Among White Women in the United States

(2016) Paige Maas et al.   JAMA Oncology

Endocytic membrane trafficking and neurodegenerative disease

(2015) Andrea M. A. Schreij et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The endosomal pathway in Parkinson's disease

(2015) Rebecca M. Perrett et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Impact of Parkinson's disease risk loci on age at onset

(2015) Christina M. Lill et al.   MOVEMENT DISORDERS

Genetic risk and age in Parkinson's disease: Continuum not stratum

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Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

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The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

PRSice: Polygenic Risk Score software

(2014) Jack Euesden et al.   BIOINFORMATICS

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation

(2014) Ian J. McGough et al.   CURRENT BIOLOGY

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation

(2014) M. R. Ambroso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

(2014) A. Beilina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stuck in traffic: an emerging theme in diseases of the nervous system

(2014) Jacques Neefjes et al.   TRENDS IN NEUROSCIENCES

Integrating Pathways of Parkinson's Disease in a Molecular Interaction Map

(2013) Kazuhiro A. Fujita et al.   MOLECULAR NEUROBIOLOGY

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

A Novel Homozygous p.R1105X Mutation of the AP4E1 Gene in Twins with Hereditary Spastic Paraplegia and Mycobacterial Disease

(2013) Xiao-Fei Kong et al.   PLoS One

CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development

(2012) Ganeshwaran H Mochida et al.   NATURE GENETICS

Genome Wide Assessment of Young Onset Parkinson’s Disease from Finland

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Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies

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Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

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A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease

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GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses

(2010) Samuli Ripatti et al.   LANCET

Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice

(2010) Y.-I. Yim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Personal genomes: The case of the missing heritability

(2008) Brendan Maher   NATURE