Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

(2017) Hisham Abdelmotilib et al.   NEUROBIOLOGY OF DISEASE

Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain

(2017) Poonam Thakur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration

(2017) Ashley S. Harms et al.   Acta Neuropathologica Communications

Propagation of pathological α-synuclein in marmoset brain

(2017) Aki Shimozawa et al.   Acta Neuropathologica Communications

Synucleinopathies: common features and hippocampal manifestations

(2016) Weiwei Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology

(2016) David H. Adamowicz et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era

(2016) Naomi P. Visanji et al.   TRENDS IN NEUROSCIENCES

Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity

(2016) Kelvin C. Luk et al.   Cell Reports

Hipposeq: a comprehensive RNA-seq database of gene expression in hippocampal principal neurons

(2016) Mark S Cembrowski et al.   eLife

Pathological α-synuclein distribution in subjects with coincident Alzheimer’s and Lewy body pathology

(2015) Jon B. Toledo et al.   ACTA NEUROPATHOLOGICA

Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease

(2015) Sandra Barral et al.   Alzheimers & Dementia

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death

(2015) A-L Mahul-Mellier et al.   CELL DEATH AND DIFFERENTIATION

Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons

(2015) Consiglia Pacelli et al.   CURRENT BIOLOGY

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

(2015) Katrina L. Paumier et al.   NEUROBIOLOGY OF DISEASE

α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation

(2015) Shijun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leveraging existing data sets to generate new insights into Alzheimer’s disease biology in specific patient subsets

(2015) Kevin D. Fowler et al.   Scientific Reports

Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease

(2015) Xinzhong Li et al.   Scientific Reports

Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism

(2015) Valerie R. Osterberg et al.   Cell Reports

Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson’s disease

(2014) Hélène Hall et al.   BRAIN

RNA-Seq Data Mining: Downregulation of NeuroD6 Serves as a Possible Biomarker for Alzheimer’s Disease Brains

(2014) Jun-ichi Satoh et al.   DISEASE MARKERS

A novel cell migratory zone in the developing hippocampal formation

(2014) Taku Sugiyama et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes

(2014) Laura A. Volpicelli-Daley et al.   MOLECULAR BIOLOGY OF THE CELL

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

Differential Expression of Alpha-Synuclein in Hippocampal Neurons

(2014) Katsutoshi Taguchi et al.   PLoS One

Pathological alpha-synuclein propagates through neural networks

(2014) Masami Masuda-Suzukake et al.   Acta Neuropathologica Communications

Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients

(2014) Karlijn J Doorn et al.   Acta Neuropathologica Communications

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study

(2013) Masaaki Hokama et al.   CEREBRAL CORTEX

A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease

(2013) Richard A. Armstrong et al.   JOURNAL OF NEURAL TRANSMISSION

Calcium Entry and  -Synuclein Inclusions Elevate Dendritic Mitochondrial Oxidant Stress in Dopaminergic Neurons

(2013) D. I. Dryanovski et al.   JOURNAL OF NEUROSCIENCE

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

(2013) Yunjong Lee et al.   NATURE NEUROSCIENCE

Advances in the genetics of Parkinson disease

(2013) Joanne Trinh et al.   Nature Reviews Neurology

Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS

(2013) Michael E. Østergaard et al.   NUCLEIC ACIDS RESEARCH

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

The neurogenic basic helix-loop-helix transcription factor NeuroD6 enhances mitochondrial biogenesis and bioenergetics to confer tolerance of neuronal PC12-NeuroD6 cells to the mitochondrial stressor rotenone

(2012) Kristin Kathleen Baxter et al.   EXPERIMENTAL CELL RESEARCH

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuronal vulnerability, pathogenesis, and Parkinson's disease

(2012) David Sulzer et al.   MOVEMENT DISORDERS

The neuropathology of genetic Parkinson's disease

(2012) Markos Poulopoulos et al.   MOVEMENT DISORDERS

In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease

(2012) S. Iannaccone et al.   PARKINSONISM & RELATED DISORDERS

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Synthesis and biophysical characterization of R-6′-Me-α-l-LNA modified oligonucleotides

(2011) Punit P. Seth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Functional models of Parkinson's disease: A valuable tool in the development of novel therapies

(2010) Peter Jenner   ANNALS OF NEUROLOGY

The Neurogenic Basic Helix-Loop-Helix Transcription Factor NeuroD6 Confers Tolerance to Oxidative Stress by Triggering an Antioxidant Response and Sustaining the Mitochondrial Biomass

(2010) Martine Uittenbogaard et al.   ASN Neuro

Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

(2009) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Neuropathology of non-motor features of Parkinson disease

(2009) Dennis W. Dickson et al.   PARKINSONISM & RELATED DISORDERS

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA