Neuronal microtubules and proteins linked to Parkinson’s disease: a relevant interaction?

Roco Proteins: GTPases with a Baroque Structure and Mechanism

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The Transcription Factor Function of Parkin: Breaking the Dogma

(2019) Cristine Alves da Costa et al.   Frontiers in Neuroscience

α-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling

(2019) Mingzhu Huang et al.   Frontiers in Neuroscience

LRRK2 links genetic and sporadic Parkinson's disease

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LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?

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The tubulin code in neuronal polarity

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Mechanism of parkin activation by PINK1

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Parkin absence accelerates microtubule aging in dopaminergic neurons

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Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease

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Microtubules and Microtubule-Associated Proteins

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LRRK2 and Rab GTPases

(2018) Suzanne R. Pfeffer   BIOCHEMICAL SOCIETY TRANSACTIONS

The role of LRRK2 in cytoskeletal dynamics

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The role of LRRK2 in cell signalling

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Tau Pathology in Parkinson's Disease

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Wild-Type Monomeric α-Synuclein Can Impair Vesicle Endocytosis and Synaptic Fidelity via Tubulin Polymerization at the Calyx of Held

(2017) Kohgaku Eguchi et al.   JOURNAL OF NEUROSCIENCE

Prying into the Prion Hypothesis for Parkinson's Disease

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Tubulin acetylation protects long-lived microtubules against mechanical ageing

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Homozygous alpha-synuclein p.A53V in familial Parkinson's disease

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Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs

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Microtubules acquire resistance from mechanical breakage through intralumenal acetylation

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Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport

(2017) Shiori Toba et al.   Scientific Reports

The Synucleinopathies: Twenty Years On

(2017) Michel Goedert et al.   Journal of Parkinsons Disease

Protein Partners of α-Synuclein in Health and Disease

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Back to the tubule: microtubule dynamics in Parkinson’s disease

(2016) Laura Pellegrini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Stability properties of neuronal microtubules

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The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease

(2016) Matthew J. Benskey et al.   JOURNAL OF NEUROCHEMISTRY

Microtubule Destabilization Paves the Way to Parkinson’s Disease

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Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects

(2016) Laurence Borgs et al.   Scientific Reports

α-Synuclein is a Novel Microtubule Dynamase

(2016) Daniele Cartelli et al.   Scientific Reports

LRRK2 Pathways Leading to Neurodegeneration

(2015) Mark R. Cookson   Current Neurology and Neuroscience Reports

Cellular processes associated with LRRK2 function and dysfunction

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Building the Neuronal Microtubule Cytoskeleton

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Post-translational modifications of tubulin: pathways to functional diversity of microtubules

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LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis

(2014) A. Raquel Esteves et al.   EXPERIMENTAL NEUROLOGY

The role of the LRRK2 gene in Parkinsonism

(2014) Jie-Qiong Li et al.   Molecular Neurodegeneration

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

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Parkin Mutations Reduce the Complexity of Neuronal Processes in iPSC-Derived Human Neurons

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Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

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G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

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Structure of the human Parkin ligase domain in an autoinhibited state

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A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation

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Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

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The Neurobiology of LRRK2 and its Role in the Pathogenesis of Parkinson’s Disease

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Novel A18T and pA29S substitutions in α-synuclein may be associated with sporadic Parkinson's disease

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Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

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Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

(2013) B.E. Riley et al.   Nature Communications

Microtubule Alterations Occur Early in Experimental Parkinsonism and The Microtubule Stabilizer Epothilone D Is Neuroprotective

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DJ-1 deficiency perturbs microtubule dynamics and impairs striatal neurite outgrowth

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LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth

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Microtubule Destabilization Is Shared by Genetic and Idiopathic Parkinson’s Disease Patient Fibroblasts

(2012) Daniele Cartelli et al.   PLoS One

Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells

(2012) Houbo Jiang et al.   Nature Communications

Binding of neuronal α-synuclein to β-III tubulin and accumulation in a model of multiple system atrophy

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Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

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α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease

(2011) Olga Corti et al.   PHYSIOLOGICAL REVIEWS

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

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Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

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α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

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Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+-induced neurodegeneration

(2010) Daniele Cartelli et al.   JOURNAL OF NEUROCHEMISTRY

Leucine-Rich Repeat Kinase 2 Is Associated With the Endoplasmic Reticulum in Dopaminergic Neurons and Accumulates in the Core of Lewy Bodies in Parkinson Disease

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LRRK2 Kinase Regulates Synaptic Morphology through Distinct Substrates at the Presynaptic and Postsynaptic Compartments of the Drosophila Neuromuscular Junction

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 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

(2009) Hong Qing et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

(2009) Rosa M. Sancho et al.   HUMAN MOLECULAR GENETICS

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?

(2009) Frank Gillardon   JOURNAL OF NEUROCHEMISTRY

Molecular interaction of α-synuclein with tubulin influences on the polymerization of microtubule in vitro and structure of microtubule in cells

(2009) R. M. Zhou et al.   MOLECULAR BIOLOGY REPORTS

Control of neuronal polarity and plasticity – a renaissance for microtubules?

(2009) Casper C. Hoogenraad et al.   TRENDS IN CELL BIOLOGY

Aberrant molecular properties shared by familial Parkinson’s disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1

(2008) Tomohiro Kabuta et al.   HUMAN MOLECULAR GENETICS

Parkin Protects Dopaminergic Neurons against Microtubule-depolymerizing Toxins by Attenuating Microtubule-associated Protein Kinase Activation

(2008) Yong Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

(2008) Payal N. Gandhi et al.   JOURNAL OF NEUROSCIENCE RESEARCH