The role of LRRK2 in cell signalling

The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2

(2018) Panagiotis S. Athanasopoulos et al.   BIOLOGICAL CHEMISTRY

Regulation of LRRK2: insights from structural and biochemical analysis

(2018) Bernd K. Gilsbach et al.   BIOLOGICAL CHEMISTRY

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

(2018) Laura Pellegrini et al.   HUMAN MOLECULAR GENETICS

LRRK2 Phosphorylation: Behind the Scenes

(2018) Tina De Wit et al.   NEUROSCIENTIST

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

(2018) James E. Tomkins et al.   PROTEOMICS

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease

(2018) Ken Y. Hui et al.   Science Translational Medicine

Leucine-Rich Repeat Kinase 2 Controls the Ca2+/Nuclear Factor of Activated T Cells/IL-2 Pathway during Aspergillus Non-Canonical Autophagy in Dendritic Cells

(2018) Alicia Yoke Wei Wong et al.   Frontiers in Immunology

The kinase LRRK2 is differently expressed in chronic rhinosinusitis with and without nasal polyps

(2018) Yue Ma et al.   Clinical and Translational Allergy

Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease

(2017) Andrew B. West   EXPERIMENTAL NEUROLOGY

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

(2017) Zhiyong Liu et al.   HUMAN MOLECULAR GENETICS

Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling

(2017) Daniel C. Berwick et al.   Molecular Neurodegeneration

A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway

(2017) Alena Salašová et al.   Molecular Neurodegeneration

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

(2017) Diana Chang et al.   NATURE GENETICS

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development

(2017) Angela J Churchill et al.   eLife

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

(2016) G. Ito et al.   BIOCHEMICAL JOURNAL

The unconventional G-protein cycle of LRRK2 and Roco proteins

(2016) S. Terheyden et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

L'RRK de Triomphe: a solution for LRRK2 GTPase activity?

(2016) J. Nixon-Abell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Back to the tubule: microtubule dynamics in Parkinson’s disease

(2016) Laura Pellegrini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cancer in Parkinson’s disease

(2016) Pawel Tacik et al.   PARKINSONISM & RELATED DISORDERS

Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity

(2016) Yang Shu et al.   PLoS One

Wnt Signaling as Master Regulator of T-Lymphocyte Responses

(2016) Frank J.T. Staal et al.   TRANSPLANTATION

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

(2016) Martin Steger et al.   eLife

Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity

(2016) Jonathon Nixon-Abell et al.   Frontiers in Molecular Neuroscience

LRRK2 Facilitates tau Phosphorylation through Strong Interaction with tau and cdk5

(2015) Mary R. Shanley et al.   BIOCHEMISTRY

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

(2015) Laura Civiero et al.   JOURNAL OF NEUROCHEMISTRY

Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells

(2015) Isabella Russo et al.   Journal of Neuroinflammation

Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2

(2015) Matthew Hamm et al.   JOURNAL OF NEUROSCIENCE RESEARCH

LRRK2 Promotes Tau Accumulation, Aggregation and Release

(2015) Patrícia Silva Guerreiro et al.   MOLECULAR NEUROBIOLOGY

Higher Frequency of Certain Cancers inLRRK2G2019S Mutation Carriers With Parkinson Disease

(2015) Ilir Agalliu et al.   JAMA Neurology

Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival

(2014) Chia-Lung Chuang et al.   HUMAN MOLECULAR GENETICS

Prediction of the Repeat Domain Structures and Impact of Parkinsonism-Associated Variations on Structure and Function of all Functional Domains of Leucine-Rich Repeat Kinase 2 (LRRK2)

(2014) Ryan D. Mills et al.   HUMAN MUTATION

LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?

(2014) Isabella Russo et al.   Journal of Neuroinflammation

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

(2014) A. Beilina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

(2014) Vinay K. Godena et al.   Nature Communications

Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β

(2013) Fumitaka Kawakami et al.   FEBS Journal

A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation

(2013) Bernard M. H. Law et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The regulation and deregulation of Wnt signaling by PARK genes in health and disease

(2013) D. C. Berwick et al.   Journal of Molecular Cell Biology

Regulation of mature T cell responses by the Wnt signaling pathway

(2012) Hai-Hui Xue et al.   Annals of the New York Academy of Sciences

The importance of Wnt signalling for neurodegeneration in Parkinson's disease

(2012) Daniel C. Berwick et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD

(2012) C-Y Chen et al.   CELL DEATH AND DIFFERENTIATION

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

(2012) Daniel C. Berwick et al.   HUMAN MOLECULAR GENETICS

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth

(2012) Fumitaka Kawakami et al.   PLoS One

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

(2012) Nicolas Dzamko et al.   PLoS One

Parkinson's Disease: Genetics and Pathogenesis

(2011) Joshua M. Shulman et al.   Annual Review of Pathology-Mechanisms of Disease

Multiple transcription factor families regulate axon growth and regeneration

(2011) Darcie L. Moore et al.   Developmental Neurobiology

Nuclear Factor of Activated T Cells (NFAT) Proteins Repress Canonical Wnt Signaling via Its Interaction with Dishevelled (Dvl) Protein and Participate in Regulating Neural Progenitor Cell Proliferation and Differentiation

(2011) Tao Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

E2F1 Regulates Cellular Growth by mTORC1 Signaling

(2011) Sebastian Real et al.   PLoS One

LRRK2 signaling pathways: the key to unlocking neurodegeneration?

(2011) Daniel C. Berwick et al.   TRENDS IN CELL BIOLOGY

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

(2010) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

Membrane Localization of LRRK2 Is Associated with Increased Formation of the Highly Active LRRK2 Dimer and Changes in Its Phosphorylation

(2010) Zdenek Berger et al.   BIOCHEMISTRY

Wnt/ -Catenin Signaling in T-Cell Immunity and Cancer Immunotherapy

(2010) L. Gattinoni et al.   CLINICAL CANCER RESEARCH

Reevaluation of Phosphorylation Sites in the Parkinson Disease-associated Leucine-rich Repeat Kinase 2

(2010) Xiaojie Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3 

(2010) C.-H. Lin et al.   JOURNAL OF NEUROSCIENCE

Wnt5a regulates distinct signalling pathways by binding to Frizzled2

(2009) Akira Sato et al.   EMBO JOURNAL

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

(2009) Rosa M. Sancho et al.   HUMAN MOLECULAR GENETICS

The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation

(2008) Elisa Greggio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY