The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance

Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1

(2019) Hatem Maamoun et al.   Frontiers in Physiology

Discovery of potent PTP1B inhibitors via structure-based drug design, synthesis and in vitro bioassay of Norathyriol derivatives

(2019) Wenjie Xue et al.   BIOORGANIC CHEMISTRY

Endoplasmic Reticulum Stress: A Critical Molecular Driver of Endothelial Dysfunction and Cardiovascular Disturbances Associated with Diabetes

(2019) Hatem Maamoun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B

(2018) Gabriel Keine Kuga et al.   EXPERIMENTAL GERONTOLOGY

Vascular endothelium dysfunction: a conservative target in metabolic disorders

(2018) Shalini Jamwal et al.   INFLAMMATION RESEARCH

Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2

(2018) Chloe Peach et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypothalamic endoplasmic reticulum stress as a key mediator of obesity-induced leptin resistance

(2018) Z. Ye et al.   Obesity Reviews

Endothelial dysfunction in diabetes and hypertension: Role of microRNAs and long non-coding RNAs

(2018) Hai-na Zhang et al.   LIFE SCIENCES

Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity

(2018) Roberto Villalobos-Labra et al.   MOLECULAR ASPECTS OF MEDICINE

A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models

(2017) Navasona Krishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Classical VEGF, Notch and Ang signalling in cancer angiogenesis, alternative approaches and future directions

(2017) Nunzia Caporarello et al.   Molecular Medicine Reports

Targeting IRE1 with small molecules counteracts progression of atherosclerosis

(2017) Ozlem Tufanli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemostasis, endothelial stress, inflammation, and the metabolic syndrome

(2017) Gerald Grandl et al.   Seminars in Immunopathology

Reduced Insulin Resistance Contributes to the Beneficial Effect of Protein Tyrosine Phosphatase-1B Deletion in a Mouse Model of Sepsis

(2017) Eugénie Delile et al.   SHOCK

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer’s Therapy?

(2017) Marcelo N. N. Vieira et al.   Frontiers in Aging Neuroscience

Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE −/− mouse model of atherosclerosis with alterations in IL10/AMPKα pathway

(2017) D. Thompson et al.   Molecular Metabolism

Vascular endothelium – Gatekeeper of vessel health

(2016) Paul A. Cahill et al.   ATHEROSCLEROSIS

Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice

(2016) Rajinikanth Gogiraju et al.   CARDIOVASCULAR RESEARCH

Obesity and Cardiovascular Disease: a Risk Factor or a Risk Marker?

(2016) Taher Mandviwala et al.   Current Atherosclerosis Reports

Role of protein tyrosine phosphatase 1B in cardiovascular diseases

(2016) Pierre-Alain Thiebaut et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Functional properties of Claramine: A novel PTP1B inhibitor and insulin-mimetic compound

(2015) Zhaohong Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deletion of protein tyrosine phosphatase 1B rescues against myocardial anomalies in high fat diet-induced obesity: Role of AMPK-dependent autophagy

(2015) Machender R. Kandadi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Rational design of allosteric-inhibition sites in classical protein tyrosine phosphatases

(2015) Cynthia M. Chio et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes

(2015) Tushar P. Patel et al.   HEART FAILURE REVIEWS

Gene Deletion of Protein Tyrosine Phosphatase 1B Protects Against Sepsis-Induced Cardiovascular Dysfunction and Mortality

(2014) David Coquerel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction

(2014) Abdelali Agouni et al.   BIOCHEMICAL PHARMACOLOGY

PTP1b Is a Physiologic Regulator of Vascular Endothelial Growth Factor Signaling in Endothelial Cells

(2014) Anthony A. Lanahan et al.   CIRCULATION

Enhanced angiogenesis and increased cardiac perfusion after myocardial infarction in protein tyrosine phosphatase 1B-deficient mice

(2014) Marie Besnier et al.   FASEB JOURNAL

The Vascular Endothelium and Human Diseases

(2014) Peramaiyan Rajendran et al.   International Journal of Biological Sciences

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

(2014) Navasona Krishnan et al.   Nature Chemical Biology

The Mechanism of Allosteric Inhibition of Protein Tyrosine Phosphatase 1B

(2014) Shuai Li et al.   PLoS One

Myeloid-Cell Protein Tyrosine Phosphatase-1B Deficiency in Mice Protects Against High-Fat Diet and Lipopolysaccharide-Induced Inflammation, Hyperinsulinemia, and Endotoxemia Through an IL-10 STAT3-Dependent Mechanism

(2013) L. Grant et al.   DIABETES

Cellular and molecular mechanisms of endothelial dysfunction in diabetes

(2013) Anna C Roberts et al.   Diabetes & Vascular Disease Research

Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice

(2013) C. Owen et al.   DIABETOLOGIA

Protein Tyrosine Phosphatase 1B and Insulin Resistance: Role of Endoplasmic Reticulum Stress/Reactive Oxygen Species/Nuclear Factor Kappa B Axis

(2013) Evgeniy Panzhinskiy et al.   PLoS One

Signal Transduction by Vascular Endothelial Growth Factor Receptors

(2013) S. Koch et al.   Cold Spring Harbor Perspectives in Medicine

Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium

(2013) Jin Qian et al.   Frontiers in Physiology

Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes

(2012) E. Panzhinskiy et al.   DIABETOLOGIA

Deficiency of PTP1B in Leptin Receptor-Expressing Neurons Leads to Decreased Body Weight and Adiposity in Mice

(2012) Ryan C. Tsou et al.   ENDOCRINOLOGY

PTP1B and TCPTP - nonredundant phosphatases in insulin signaling and glucose homeostasis

(2012) Tony Tiganis   FEBS Journal

Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B

(2012) Elodie Gomez et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Correction: Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and Is a Minor Regulator of Glucose Homeostasis

(2012) Carl Owen et al.   PLoS One

Protein Tyrosine Phosphatase 1B Deficiency Potentiates PERK/eIF2α Signaling in Brown Adipocytes

(2012) Ahmed Bettaieb et al.   PLoS One

Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress

(2011) Abdelali Agouni et al.   BIOCHEMICAL JOURNAL

Differential Regulation of Endoplasmic Reticulum Stress by Protein Tyrosine Phosphatase 1B and T Cell Protein Tyrosine Phosphatase

(2011) Ahmed Bettaieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Resistance: the Link Between Obesity and Cardiovascular Disease

(2011) Gerald M. Reaven   MEDICAL CLINICS OF NORTH AMERICA

Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development

(2010) Alastair J Barr   Future Medicinal Chemistry

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

(2010) Ryoichi Banno et al.   JOURNAL OF CLINICAL INVESTIGATION

HLA-B35 Upregulates Endothelin-1 and Downregulates Endothelial Nitric Oxide Synthase via Endoplasmic Reticulum Stress Response in Endothelial Cells

(2010) S. Lenna et al.   JOURNAL OF IMMUNOLOGY

Chronic Endoplasmic Reticulum Stress Activates Unfolded Protein Response in Arterial Endothelium in Regions of Susceptibility to Atherosclerosis

(2009) Mete Civelek et al.   CIRCULATION RESEARCH

Deletion of Protein Tyrosine Phosphatase 1b Improves Peripheral Insulin Resistance and Vascular Function in Obese, Leptin-Resistant Mice via Reduced Oxidant Tone

(2009) M. Irfan Ali et al.   CIRCULATION RESEARCH

Inhibition of PTP1B Restores IRS1-Mediated Hepatic Insulin Signaling in IRS2-Deficient Mice

(2009) A. Gonzalez-Rodriguez et al.   DIABETES

Inhibition of Protein Tyrosine Phosphatase-1B with Antisense Oligonucleotides Improves Insulin Sensitivity and Increases Adiponectin Concentrations in Monkeys

(2009) Michael M. Swarbrick et al.   ENDOCRINOLOGY

Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

(2009) Annemarieke E. Loot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

(2009) Ebru Erbay et al.   NATURE MEDICINE

Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

(2009) L. Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How IRE1 Reacts to ER Stress

(2008) David Ron et al.   CELL

Endothelial Dysfunction in Diabetes: From Mechanisms to Therapeutic Targets

(2008) Maria Potenza et al.   CURRENT MEDICINAL CHEMISTRY

Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo

(2008) E. R. Duncan et al.   DIABETES

Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress

(2008) M. Delibegovic et al.   DIABETES

An Integrated View of Insulin Resistance and Endothelial Dysfunction

(2008) Ranganath Muniyappa et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammationin Vivo

(2008) Janice M. Zabolotny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Agonist-Stimulated Endothelial Nitric Oxide Synthase Activation and Vascular Relaxation

(2007) David Fulton et al.   CIRCULATION RESEARCH

The discovery of nitric oxide and its role in vascular biology

(2006) S Moncada et al.   BRITISH JOURNAL OF PHARMACOLOGY