Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

Mechanisms of small-molecule binding to intrinsically disordered proteins: Figure 1

(2012) Rémi Cuchillo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

PTP1B Is an Androgen Receptor-Regulated Phosphatase That Promotes the Progression of Prostate Cancer

(2012) L. Lessard et al.   CANCER RESEARCH

Small molecule tools for functional interrogation of protein tyrosine phosphatases

(2012) Rongjun He et al.   FEBS Journal

PTP1B and TCPTP - nonredundant phosphatases in insulin signaling and glucose homeostasis

(2012) Tony Tiganis   FEBS Journal

Protein tyrosine phosphatases - from housekeeping enzymes to master regulators of signal transduction

(2012) Nicholas K. Tonks   FEBS Journal

Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'

(2011) G. Lin et al.   GENES & DEVELOPMENT

Protein-tyrosine Phosphatase 1B Modulates Early Endosome Fusion and Trafficking of Met and Epidermal Growth Factor Receptors

(2011) Veena Sangwan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

(2011) Florian Wiede et al.   JOURNAL OF CLINICAL INVESTIGATION

PTP1B expression contributes to gastric cancer progression

(2011) Jinguo Wang et al.   MEDICAL ONCOLOGY

Epithelial Protein-Tyrosine Phosphatase 1B Contributes to the Induction of Mammary Tumors by HER2/Neu but Is Not Essential for Tumor Maintenance

(2011) K. K. Balavenkatraman et al.   MOLECULAR CANCER RESEARCH

PTP1B Suppresses Prolactin Activation of Stat5 in Breast Cancer Cells

(2010) Kevin J. Johnson et al.   AMERICAN JOURNAL OF PATHOLOGY

Suppression of PTP1B in gastric cancer cellsin vitroinduces a change in the genome-wide expression profile and inhibits gastric cancer cell growth

(2010) Jinguo Wang et al.   CELL BIOLOGY INTERNATIONAL

Intrinsically disordered proteins are potential drug targets

(2010) Steven J Metallo   CURRENT OPINION IN CHEMICAL BIOLOGY

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

(2010) Jianming Zhang et al.   NATURE

Inhibition of PTP1B by Trodusquemine (MSI-1436) Causes Fat-specific Weight Loss in Diet-induced Obese Mice

(2010) Kristen A. Lantz et al.   Obesity

Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

(2009) Dalia I. Hammoudeh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acquired resistance to tyrosine kinase inhibitors during cancer therapy

(2008) Jeffrey A Engelman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

(2008) Michael A. Hanson et al.   STRUCTURE