A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models

Recent Advances in Protein Tyrosine Phosphatase 1B Targeted Drug Discovery for Type II Diabetes and Obesity

(2018) Neelesh Maheshwari et al.   CURRENT DRUG TARGETS

Diabetes and Alzheimer’s Disease: Can Elevated Free Copper Predict the Risk of the Disease?

(2017) Rosanna Squitti et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting Tyrosine Phosphatases: Time to End the Stigma

(2017) Stephanie M. Stanford et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

(2016) Ying-Nan P. Chen et al.   NATURE

Targeting cancer with kinase inhibitors

(2015) Stefan Gross et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein tyrosine phosphatases as potential therapeutic targets

(2014) Rong-jun He et al.   ACTA PHARMACOLOGICA SINICA

Protein Tyrosine Phosphatase Inhibition by Metals and Metal Complexes

(2014) Liping Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Metallodrugs in Medicinal Inorganic Chemistry

(2014) Katja Dralle Mjos et al.   CHEMICAL REVIEWS

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

(2014) Navasona Krishnan et al.   Nature Chemical Biology

PTP1B: A simple enzyme for a complex world

(2013) Matthew Feldhammer et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Integrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery

(2013) Katie R. Martin et al.   METHODS

Selective Divalent Copper Chelation for the Treatment of Diabetes Mellitus

(2012) G. J.S. Cooper   CURRENT MEDICINAL CHEMISTRY

Protein tyrosine phosphatases - from housekeeping enzymes to master regulators of signal transduction

(2012) Nicholas K. Tonks   FEBS Journal

Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity

(2011) Aftabul Haque et al.   CELL

Metal-based anti-diabetic drugs: advances and challenges

(2011) Aviva Levina et al.   DALTON TRANSACTIONS

Coordination chemistry of copper proteins: How nature handles a toxic cargo for essential function

(2011) Jeffrey T. Rubino et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Targeting proteins with metal complexes

(2009) Eric Meggers   CHEMICAL COMMUNICATIONS

Application of Metal Coordination Chemistry To Explore and Manipulate Cell Biology

(2009) Kathryn L. Haas et al.   CHEMICAL REVIEWS

Role of Copper Ion in the Pathogenesis of Type 2 Diabetes

(2009) Ayako TANAKA et al.   ENDOCRINE JOURNAL

A potential role for protein tyrosine phosphatase inhibition by a RuIII–edta complex (edta = ethylenediaminetetraacetate) in its biological activity

(2008) Debabrata Chatterjee et al.   CHEMICAL COMMUNICATIONS

Gold(I)-Mediated Inhibition of Protein Tyrosine Phosphatases: A Detailed in Vitro and Cellular Study

(2008) Divya Krishnamurthy et al.   JOURNAL OF MEDICINAL CHEMISTRY