Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development

Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity

(2010) Deju Ye et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel SHP-1 Inhibitors Tyrosine Phosphatase Inhibitor-1 and Analogs with Preclinical Anti-Tumor Activities as Tolerated Oral Agents

(2010) S. Kundu et al.   JOURNAL OF IMMUNOLOGY

Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)

(2010) Xian Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of PTP1B by Trodusquemine (MSI-1436) Causes Fat-specific Weight Loss in Diet-induced Obese Mice

(2010) Kristen A. Lantz et al.   Obesity

Increased Susceptibility to Dextran Sulfate Sodium Induced Colitis in the T Cell Protein Tyrosine Phosphatase Heterozygous Mouse

(2010) Syed-Wajahat Hassan et al.   PLoS One

Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases

(2010) Stephanie M. Stanford et al.   Seminars in Immunopathology

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

(2009) Y. A. Senis et al.   BLOOD

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

(2009) Alastair J. Barr et al.   CELL

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

In Silico Screening for PTPN22 Inhibitors: Active Hits from an Inactive Phosphatase Conformation

(2009) Shuangding Wu et al.   ChemMedChem

Drug Discovery and Protein Tyrosine Phosphatases

(2009) Mark Blaskovich   CURRENT MEDICINAL CHEMISTRY

Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551

(2009) S. Fukuda et al.   DIABETES OBESITY & METABOLISM

Inhibition of Protein Tyrosine Phosphatase-1B with Antisense Oligonucleotides Improves Insulin Sensitivity and Increases Adiponectin Concentrations in Monkeys

(2009) Michael M. Swarbrick et al.   ENDOCRINOLOGY

Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase

(2009) Mark R. Karver et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Recent Advances in the Discovery of Competitive Protein Tyrosine Phosphatase 1B Inhibitors for the Treatment of Diabetes, Obesity, and Cancer

(2009) Andrew P. Combs   JOURNAL OF MEDICINAL CHEMISTRY

Physiological Signaling Specificity by Protein Tyrosine Phosphatases

(2009) Matthew Soulsby et al.   PHYSIOLOGY

Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase

(2008) Yuli Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The tyrosine phosphatase Shp2 (PTPN11) in cancer

(2008) Gordon Chan et al.   CANCER AND METASTASIS REVIEWS

Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress

(2008) M. Delibegovic et al.   DIABETES

Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities

(2008) Atul Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discontinued drug in 2007: renal, endocrine and metabolic drugs

(2008) Jerry R Colca   EXPERT OPINION ON INVESTIGATIONAL DRUGS

SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis

(2008) X Zhou et al.   HISTOPATHOLOGY

2-Thiazolylimino/Heteroarylimino-5-arylidene-4-thiazolidinones as New Agents with SHP-2 Inhibitory Action

(2008) A. Geronikaki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds

(2008) Harshani R. Lawrence et al.   JOURNAL OF MEDICINAL CHEMISTRY

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

(2008) K. Hellmuth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines

(2007) Brent Douty et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS