Wnt/β-catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind

An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group

(2019) Premika S. W. Boedhoe et al.   Frontiers in Neuroinformatics

Stress transforms lateral habenula reward responses into punishment signals

(2019) Steven J. Shabel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical and Subcortical Brain Morphometry Differences Between Patients With Autism Spectrum Disorder and Healthy Individuals Across the Lifespan: Results From the ENIGMA ASD Working Group

(2018) Daan van Rooij et al.   AMERICAN JOURNAL OF PSYCHIATRY

Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

(2018) Theo G.M. van Erp et al.   BIOLOGICAL PSYCHIATRY

Wnt signalling: conquering complexity

(2018) Katrin E. Wiese et al.   DEVELOPMENT

Tcf7L2 is essential for neurogenesis in the developing mouse neocortex

(2018) Olga Chodelkova et al.   Neural Development

Severely impaired adult brain neurogenesis in cyclin D2 knock-out mice produces very limited phenotypic changes

(2018) Robert K. Filipkowski et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding

(2018) Alexander B. Rosenberg et al.   SCIENCE

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

(2018) Michael J. Gandal et al.   SCIENCE

Neogenin, a regulator of adult hippocampal neurogenesis, prevents depressive-like behavior

(2018) Dong Sun et al.   Cell Death & Disease

Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates

(2018) Pedro Baptista et al.   Frontiers in Neuroanatomy

Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids

(2018) Priya Srikanth et al.   Translational Psychiatry

Prioritized High-Confidence Risk Genes for Intellectual Disability Reveal Molecular Convergence During Brain Development

(2018) Zhenwei Liu et al.   Frontiers in Genetics

The involvement of the canonical Wnt-signaling receptor LRP5 and LRP6 gene variants with ADHD and sexual dimorphism: Association study and meta-analysis

(2018) Edna Grünblatt et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Influence of CTNNB1 rs2953 polymorphism on schizophrenia susceptibility in Chinese Han population through modifying miR-485 binding to CTNNB1

(2018) Xiaojing Guo et al.   GENES BRAIN AND BEHAVIOR

The Cognitive Thalamus as a Gateway to Mental Representations

(2018) Mathieu Wolff et al.   JOURNAL OF NEUROSCIENCE

Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development

(2018) Donna L. McPhie et al.   Translational Psychiatry

Genetic and Epigenetic Alterations Underlie Oligodendroglia Susceptibility and White Matter Etiology in Psychiatric Disorders

(2018) Xianjun Chen et al.   Frontiers in Genetics

Mechanisms of radial glia progenitor cell lineage progression

(2017) Robert Beattie et al.   FEBS LETTERS

Addressing reverse inference in psychiatric neuroimaging: Meta-analyses of task-related brain activation in common mental disorders

(2017) Emma Sprooten et al.   HUMAN BRAIN MAPPING

Potential Applications of the National Institute of Mental Health’s Research Domain Criteria (RDoC) to Clinical Psychiatric Practice

(2017) Joel Yager et al.   JOURNAL OF CLINICAL PSYCHIATRY

Transcription factor 7 like 2 promotes oligodendrocyte differentiation and remyelination

(2017) Chao Weng et al.   Molecular Medicine Reports

Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group

(2017) D P Hibar et al.   MOLECULAR PSYCHIATRY

Prevalence and architecture of de novo mutations in developmental disorders

(2017)   NATURE

TCF7L2 mediates the cellular and behavioral response to chronic lithium treatment in animal models

(2017) Katarzyna Misztal et al.   NEUROPHARMACOLOGY

The habenula in psychiatric disorders: More than three decades of translational investigation

(2017) Marc Fakhoury   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neural Progenitor Cell Polarity and Cortical Development

(2017) Yoko Arai et al.   Frontiers in Cellular Neuroscience

Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior

(2017) Riccardo Bocchi et al.   Nature Communications

Lef1-dependent hypothalamic neurogenesis inhibits anxiety

(2017) Yuanyuan Xie et al.   PLOS BIOLOGY

Genome Sequencing of Autism-Affected Families Reveals Disruption of Putative Noncoding Regulatory DNA

(2016) Tychele N. Turner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mapping Thalamocortical Functional Connectivity in Chronic and Early Stages of Psychotic Disorders

(2016) Neil D. Woodward et al.   BIOLOGICAL PSYCHIATRY

Accumulating evidence for a role of TCF7L2 variants in bipolar disorder with elevated body mass index

(2016) Alfredo B Cuellar-Barboza et al.   BIPOLAR DISORDERS

Gene-based analyses reveal novel genetic overlap and allelic heterogeneity across five major psychiatric disorders

(2016) Huiying Zhao et al.   HUMAN GENETICS

Metabolic pathways in the periphery and brain: Contribution to mental disorders?

(2016) Andrzej Nagalski et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors

(2016) H Belinson et al.   MOLECULAR PSYCHIATRY

Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

(2016) L Schmaal et al.   MOLECULAR PSYCHIATRY

Subcortical volumetric abnormalities in bipolar disorder

(2016) D P Hibar et al.   MOLECULAR PSYCHIATRY

Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

(2016) Omer Durak et al.   NATURE NEUROSCIENCE

Genetic Background Limits Generalizability of Genotype-Phenotype Relationships

(2016) Laura J. Sittig et al.   NEURON

The serotonin system in autism spectrum disorder: From biomarker to animal models

(2016) C.L. Muller et al.   NEUROSCIENCE

Neuregulin-1 and schizophrenia in the genome-wide association study era

(2016) Md Shaki Mostaid et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

β-Catenin-Independent Roles of Wnt/LRP6 Signaling

(2016) Sergio P. Acebron et al.   TRENDS IN CELL BIOLOGY

Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders

(2016) Alessandro Guidotti et al.   Frontiers in Cellular Neuroscience

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation

(2016) Chuntao Zhao et al.   Nature Communications

Cell proliferation is reduced in the hippocampus in schizophrenia

(2015) Katherine M Allen et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

The current state of the neurogenic theory of depression and anxiety

(2015) Bradley R Miller et al.   CURRENT OPINION IN NEUROBIOLOGY

How to make an oligodendrocyte

(2015) S. A. Goldman et al.   DEVELOPMENT

The Wnt Effector Transcription Factor 7-Like 2 Positively Regulates Oligodendrocyte Differentiation in a Manner Independent of Wnt/ -Catenin Signaling

(2015) E. Hammond et al.   JOURNAL OF NEUROSCIENCE

Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities

(2015) J M Madison et al.   MOLECULAR PSYCHIATRY

Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group

(2015) L Schmaal et al.   MOLECULAR PSYCHIATRY

Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

(2015) T G M van Erp et al.   MOLECULAR PSYCHIATRY

Lhx2 regulates the timing of β-catenin-dependent cortical neurogenesis

(2015) Lea Chia-Ling Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beta-catenin in schizophrenia: Possibly deleterious novel mutation

(2015) Anastasia Levchenko et al.   PSYCHIATRY RESEARCH

Differentiation of oligodendrocyte precursors is impaired in the prefrontal cortex in schizophrenia

(2015) Sarah A. Mauney et al.   SCHIZOPHRENIA RESEARCH

N-cadherin-based adherens junction regulates the maintenance, proliferation, and differentiation of neural progenitor cells during development

(2015) Yasunori Miyamoto et al.   Cell Adhesion & Migration

Identification of a Common Neurobiological Substrate for Mental Illness

(2015) Madeleine Goodkind et al.   JAMA Psychiatry

Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF

(2014) Jurian Schuijers et al.   EMBO JOURNAL

Stage-Specific Regulation of Oligodendrocyte Development by Wnt/ -Catenin Signaling

(2014) Z.-M. Dai et al.   JOURNAL OF NEUROSCIENCE

β-catenin mediates stress resilience through Dicer1/microRNA regulation

(2014) Caroline Dias et al.   NATURE

Large-scale discovery of novel genetic causes of developmental disorders

(2014) T. W. Fitzgerald et al.   NATURE

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Wnt/β-Catenin Signaling Regulates Sequential Fate Decisions of Murine Cortical Precursor Cells

(2014) Kalina Draganova et al.   STEM CELLS

Schizophrenia: susceptibility genes and oligodendroglial and myelin related abnormalities

(2014) Panos Roussos et al.   Frontiers in Cellular Neuroscience

Evidence for dysregulation of axonal growth and guidance in the etiology of ASD

(2013) Kathryn McFadden et al.   Frontiers in Human Neuroscience

Association Study of 167 Candidate Genes for Schizophrenia Selected by a Multi-Domain Evidence-Based Prioritization Algorithm and Neurodevelopmental Hypothesis

(2013) Zhongming Zhao et al.   PLoS One

Wnts in action: from synapse formation to synaptic maintenance

(2013) Ellen M. Dickins et al.   Frontiers in Cellular Neuroscience

A rare WNT1 missense variant overrepresented in ASD leads to increased Wnt signal pathway activation

(2013) P-M Martin et al.   Translational Psychiatry

BDNF and Schizophrenia: From Neurodevelopment to Neuronal Plasticity, Learning, and Memory

(2013) R. Nieto et al.   Frontiers in Psychiatry

Novel β-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability

(2012) Marta B Wisniewska et al.   BMC GENOMICS

The expression and activity of β-catenin in the thalamus and its projections to the cerebral cortex in the mouse embryo

(2012) Thomas Pratt et al.   BMC NEUROSCIENCE

Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain

(2012) A. Nagalski et al.   Brain Structure & Function

Investigating Tonic Wnt Signaling Throughout the Adult CNS and in the Hippocampal Neurogenic Niche of BatGal and Ins-TopGal Mice

(2012) David S. Garbe et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Visualization and exploration of Tcf/Lef function using a highly responsive Wnt/β-catenin signaling-reporter transgenic zebrafish

(2012) Nobuyuki Shimizu et al.   DEVELOPMENTAL BIOLOGY

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

KCNIP4 as a candidate gene for personality disorders and adult ADHD

(2012) Lena Weißflog et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Association of the Type 2 Diabetes Mellitus Susceptibility Gene, TCF7L2, with Schizophrenia in an Arab-Israeli Family Sample

(2012) Anna Alkelai et al.   PLoS One

Deletion of GSK3  in D2R-expressing neurons reveals distinct roles for  -arrestin signaling in antipsychotic and lithium action

(2012) N. M. Urs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior

(2012) J. Veenstra-VanderWeele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCF/LEFs and Wnt Signaling in the Nucleus

(2012) K. M. Cadigan et al.   Cold Spring Harbor Perspectives in Biology

How do they do Wnt they do?: regulation of transcription by the Wnt/β-catenin pathway

(2011) H. C. Archbold et al.   Acta Physiologica

Disruption of glycogen synthase kinase-3-beta activity leads to abnormalities in physiological measures in mice

(2011) A. Ahnaou et al.   BEHAVIOURAL BRAIN RESEARCH

At-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia

(2011) Thomas Hansen et al.   BIOLOGICAL PSYCHIATRY

Development and Evolution of the Human Neocortex

(2011) Jan H. Lui et al.   CELL

WNT Protein-independent Constitutive Nuclear Localization of β-Catenin Protein and Its Low Degradation Rate in Thalamic Neurons

(2011) Katarzyna Misztal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Role of the WNT-Dishevelled-GSK3  Signaling Cascade in the Mouse Nucleus Accumbens in a Social Defeat Model of Depression

(2011) M. B. Wilkinson et al.   JOURNAL OF NEUROSCIENCE

Wnt Signaling Regulates Neuronal Differentiation of Cortical Intermediate Progenitors

(2011) R. N. Munji et al.   JOURNAL OF NEUROSCIENCE

Modulation of Tcf7l2 Expression Alters Behavior in Mice

(2011) Daniel Savic et al.   PLoS One

Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis

(2011) O. Karalay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt2 Expression and Signaling Is Increased by Different Classes of Antidepressant Treatments

(2010) Hideki Okamoto et al.   BIOLOGICAL PSYCHIATRY

Wnts Influence the Timing and Efficiency of Oligodendrocyte Precursor Cell Generation in the Telencephalon

(2010) A. J. Langseth et al.   JOURNAL OF NEUROSCIENCE

Deficiency in the Inhibitory Serine-Phosphorylation of Glycogen Synthase Kinase-3 Increases Sensitivity to Mood Disturbances

(2010) Abigail Polter et al.   NEUROPSYCHOPHARMACOLOGY

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

Kaiso is a bimodal modulator for Wnt/β-catenin signaling

(2009) Hidekazu Iioka et al.   FEBS LETTERS

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

(2009) S. P.J. Fancy et al.   GENES & DEVELOPMENT

 -Catenin Signaling Levels in Progenitors Influence the Laminar Cell Fates of Projection Neurons

(2009) C. A. Mutch et al.   JOURNAL OF NEUROSCIENCE

Wnt signaling is sufficient to perturb oligodendrocyte maturation

(2009) Keith Feigenson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

(2009) Feng Ye et al.   NATURE NEUROSCIENCE

Signals from the edges: The cortical hem and antihem in telencephalic development

(2009) Lakshmi Subramanian et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Neocortical neurogenesis: morphogenetic gradients and beyond

(2009) Verne S. Caviness et al.   TRENDS IN NEUROSCIENCES

A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia

(2009) Anna C. Need et al.   PLoS Genetics

Association Study of Wnt Signaling Pathway Genes in Bipolar Disorder

(2008) Peter P. Zandi   ARCHIVES OF GENERAL PSYCHIATRY

Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool

(2008) Nina Solberg et al.   DEVELOPMENTAL DYNAMICS

Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women

(2008) Sagiv Shifman et al.   PLoS Genetics