Article
Neurosciences
Julia M. Huntenburg, Ling Yun Yeow, Francesca Mandino, Joanes Grandjean
Summary: The study found robust spatial patterns of resting-state functional connectivity gradients in the mouse cortex, with the principal gradient showing a striking overlap with an axis of neocortical evolution from two primordial origins. Additional gradients reflect sensory specialization and aspects of a sensory-to-transmodal hierarchy, and are associated with transcriptomic features.
Article
Developmental Biology
Jisoo S. Han, Elizabeth Fishman-Williams, Steven C. Decker, Keiko Hino, Raenier V. Reyes, Nadean L. Brown, Sergi Simo, Anna La Torre
Summary: The central nervous system is composed of different types of cells derived from multipotent neural progenitors. Spatial position and temporal cues play important roles in determining the fate of neural progenitors and generating various cell populations. Notch signaling pathway has been found to be crucial in this process, particularly in the development of neocortex and hippocampus, as well as the corpus callosum and choroid plexus. Notch signaling controls the fate determination of projection neurons in the neocortex through the regulation of two microRNA clusters, including let-7, miR-99a/100, and miR-125b. The interplay between Notch and miRNAs is essential for the regulation of neocortical progenitor behaviors and neuron cell fate decisions.
Article
Cell Biology
Jinyue Zhao, Chao Feng, Wenwen Wang, Libo Su, Jianwei Jiao
Summary: Neocortex expansion and folding are linked to human intelligence and cognition. The study discovered that the overexpression of the SERPINA3 gene can induce neocortical folding, increase neuron abundance, and improve cognitive abilities. Further investigation revealed that SERPINA3 promotes the proliferation of outer radial glia and affects cortical folding.
Review
Neurosciences
Yuki Bando, Masaru Ishibashi, Satoru Yamagishi, Atsuo Fukuda, Kohji Sato
Summary: This review summarizes the functions of ion channels and transporters in neocortical development and discusses the links between channelopathies and neocortical development. Furthermore, it introduces emerging optical techniques for studying neocortical development and the pathophysiology of channelopathies.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Neurosciences
Takashi Namba, Jeannette Nardelli, Pierre Gressens, Wieland B. Huttner
Summary: The neocortex has expanded in certain mammals such as primates, including humans, and NPC metabolism is now recognized as a major regulator of NPC proliferation in neocortical development. Insights into the role of NPC metabolism in neurodevelopmental disorders and its relevance for neocortex evolution have been summarized, highlighting the impact of metabolism on NPC proliferation and neocortical development.
Article
Multidisciplinary Sciences
Nobuhiro Kurabayashi, Kazuki Fujii, Yuta Otobe, Shingo Hiroki, Masaharu Hiratsuka, Hikari Yoshitane, Yasuhiro Kazuki, Keizo Takao
Summary: Through studying the TcMAC21 mouse model, we found that it exhibits similar brain developmental abnormalities as individuals with Down syndrome (DS), making it a valuable model for investigating the causes of intellectual disability in DS individuals.
Review
Cell Biology
Belal Shohayeb, Zukhrofi Muzar, Helen M. Cooper
Summary: This review discusses the fundamental molecular and cellular mechanisms regulating neural progenitor function and neuronal diversity generation, as well as the essential structural features of cortical neurons' origin, proliferation, and differentiation. Furthermore, researchers have also explored how individual neuronal identity emerges as a result of exposure to temporally regulated extrinsic cues.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Elvis Dohmatob, Hugo Richard, Ana Luisa Pinho, Bertrand Thirion
Summary: Functional neuroimaging allows characterization of brain spatial organization based on response to tasks or ongoing activity, with the concept of organization remaining elusive. Researchers quantitatively assessed local gradient-based models to predict functional features, developing a parcel-wise linear regression model based on reference topographies. Multiple random parcellations were used to predict functional features, demonstrating the existence of an optimal grouping for capturing local gradients.
Review
Biochemistry & Molecular Biology
Kseniia Sarieva, Simone Mayer
Summary: The translation provides an overview of how prenatal environmental adversity impacts human brain development and the use of brain organoids to study these effects. It also highlights the challenges in the field, such as protocol variability and a lack of benchmarking for cross-study comparisons.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Cell Biology
Daniel N. Srole, Tomas Ganz
Summary: ERFE is the main erythroid regulator that suppresses hepcidin synthesis and mobilizes cellular iron stores for heme synthesis. In conditions of ineffective erythropoiesis, the overproduction of ERFE can cause iron overload.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Zhigang Xie, Vytas A. Bankaitis
Summary: During embryonic development, the neocortex undergoes explosive expansion, with disproportionate growth in the neural stem cell layer. A signaling axis involving phosphatidylinositol transfer protein (PITP) and non-canonical Wnt planar cell polarity (ncPCP) promotes tangential expansion of the neocortex. This expansion is crucial for the development of the cerebral wall and has implications for neurodevelopmental disorders.
Review
Physiology
Heiko J. Luhmann
Summary: The neocortical network is composed of excitatory and inhibitory neurons, organized in microcircuits that provide various types of neural connections and influences. This network is activated by specific inputs from thalamic nuclei, subcortical regions, and cortico-cortical projections. Different types of neurons in the neocortex have unique firing patterns, synaptic connectivity, and dynamics of their interactions. Repetitive stimulation can activate or inactivate microcircuits within the neocortex. Specific networks within the neocortex generate synchronized activity patterns that contribute to higher cognitive function and behavior. This review provides an overview of the current understanding of the structure and function of the neocortical network.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Cell Biology
Mohammed Shqirat, Akira Kinoshita, Ryoichiro Kageyama, Toshiyuki Ohtsuka
Summary: An expanded and folded neocortex is characteristic of higher mammals, including humans and other primates. Shh overexpression during embryogenesis can promote the symmetric proliferative division of NSCs in the neocortical region, resulting in the expansion of the neocortex.
Article
Neurosciences
Michele Angelo Colombo, Angela Comanducci, Silvia Casarotto, Chiara-Camilla Derchi, Jitka Annen, Alessandro Vigano, Alice Mazza, Pietro Davide Trimarchi, Melanie Boly, Matteo Fecchio, Olivier Bodart, Jorge Navarro, Steven Laureys, Olivia Gosseries, Marcello Massimini, Simone Sarasso, Mario Rosanova
Summary: Neurophysiological markers, such as EEG alpha power and spatio-spectral gradients, can be used to assess Disorders of Consciousness (DoC). Alpha power alone is not a reliable marker of consciousness and is suppressed in severe postanoxia cases. EEG spatio-spectral gradients, on the other hand, are a robust and generalizable marker that accurately stratify patients' consciousness, even in unresponsive cases. The clinical application of these markers can guide rehabilitation efforts.
Article
Multidisciplinary Sciences
Simone Holler, German Kostinger, Kevan A. C. Martin, Gregor F. P. Schuhknecht, Ken J. Stratford
Summary: Researchers reconstructed mammalian brain circuits using high-throughput electron-microscopic techniques, revealing a linear relationship between synapse size and strength, which provides a key missing link in assigning physiological weights to neuronal wiring diagrams. Additionally, their study found that neocortical synapses operate with multivesicular release, suggesting they are more complex computational devices than previously thought.
Article
Psychology, Developmental
Joseph Biederman, Maura Fitzgerald, Thomas J. Spencer, Pradeep G. Bhide, Deirdre M. McCarthy, K. Yvonne Woodworth, Alexandra Saunders, Stephen V. Faraone
JOURNAL OF ATTENTION DISORDERS
(2020)
Article
Biochemistry & Molecular Biology
Deirdre M. McCarthy, Thomas J. Morgan, Sarah E. Lowe, Matthew J. Williamson, Thomas J. Spencer, Joseph Biederman, Pradeep G. Bhide
Article
Neurosciences
Melissa M. Martin, Deirdre M. McCarthy, Chris Schatschneider, Mia X. Trupiano, Sara K. Jones, Aishani Kalluri, Pradeep G. Bhide
Review
Cell Biology
Ann Marie Centner, Pradeep G. Bhide, Gloria Salazar
Article
Neurosciences
Russell W. Brown, Pradeep G. Bhide, W. Drew Gill, Loren D. Peeters
PSYCHOPHARMACOLOGY
(2020)
Article
Multidisciplinary Sciences
Deirdre M. McCarthy, Sarah E. Lowe, Thomas J. Morgan, Elisa N. Cannon, Joseph Biederman, Thomas J. Spencer, Pradeep G. Bhide
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Lin Zhang, Deirdre M. McCarthy, Karen L. Eskow Jaunarajs, Joseph Biederman, Thomas J. Spencer, Pradeep G. Bhide
Summary: The study indicates that the KOR antagonist norbinaltorphimine (norBNI) and methylphenidate can improve attention and working memory in the PNE mouse model by increasing dopamine and noradrenaline release.
Article
Neurosciences
Samantha Pavlock, Deirdre M. McCarthy, Anisha Kesarwani, Pascal Jean-Pierre, Pradeep G. Bhide
Summary: The combination of the chemotherapy drug cyclophosphamide (CP) and the anti-inflammatory drug naproxen can affect hippocampal inflammation. However, individually using CP, naproxen, or undergoing ovariectomy does not cause significant cognitive changes associated with chemo brain. Only the combination of CP and ovariectomy has a significant effect on depression-like behavior, which is a comorbidity of chemo brain.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Reproductive Biology
Deirdre M. McCarthy, Pradeep G. Bhide
Summary: Research has expanded our understanding of how genetic and environmental factors interact to shape behavioral phenotypes, including environment-induced epigenetic modifications and their potential association with heritable behavioral phenotypes. The molecular basis of phenotypes resulting from environment-induced epigenetic modifications is not well defined, but there is accumulating phenomenological evidence in support of it. Attention has turned to epigenetic modification of germ cells as a possible mechanism of heritability, particularly focusing on the heritable effects of environmental influences on male founders.
BIOLOGY OF REPRODUCTION
(2021)
Article
Critical Care Medicine
Lin Zhang, Cathy W. Levenson, Valentina Cea Salazar, Joseph Biederman, Ross Zafonte, Pradeep G. Bhide
Summary: Attention deficit hyperactivity disorder (ADHD) may increase the risk for repetitive mild traumatic brain injury (mTBI) and result in poor neurocognitive outcomes. This study using a mouse model found that ADHD and repetitive mTBI contribute to transient novelty-seeking and depression-like behavior.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Behavioral Sciences
Gloria S. Lee, Devon L. Graham, Brenda L. Noble, Taylor S. Trammell, Deirdre M. McCarthy, Lisa R. Anderson, Marcelo Rubinstein, Pradeep G. Bhide, Gregg D. Stanwood
Summary: The study explores the impact of the loss of D2R in specific cell types in the cerebral cortex on neurobehavioral and cellular development. The findings suggest distinct roles for D2R in excitatory and inhibitory neurons in regulating behavior and interneuron development. These findings have important implications for understanding the role of D2R in cortical circuit formation and brain disorders.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Deirdre M. M. McCarthy, Lin Zhang, Bradley J. J. Wilkes, David E. E. Vaillancourt, Joseph Biederman, Pradeep G. G. Bhide
Summary: The use of tobacco products during pregnancy increases the risk of neurodevelopmental disorders in offspring. Preclinical models have provided insights into the effects of developmental nicotine exposure on the brain, showing lasting effects on brain structure, neurotransmitter signaling, and behavior. These models have also contributed to the discovery of potential treatments for attention deficit hyperactivity disorder and demonstrated the heritability of behavioral phenotypes from nicotine-exposed parents to multiple generations. Additionally, research using these models has shown synergistic interactions between developmental nicotine exposure and repetitive mild traumatic brain injury in individuals with attention deficit hyperactivity disorder.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Multidisciplinary Sciences
Sara K. Jones, Deirdre M. McCarthy, Cynthia Vied, Gregg D. Stanwood, Chris Schatschneider, Pradeep G. Bhide
Summary: This study reports the effects of aspartame on anxiety-like behavior, neurotransmitter signaling, and gene expression in the amygdala. Mice drinking water with aspartame exhibited anxiety-like behavior and had altered gene expression in the amygdala. The changes in behavior and gene expression were also observed in the offspring.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Letter
Multidisciplinary Sciences
Sara K. Jones, Deirdre M. McCarthy, Cynthia Vied, Gregg D. Stanwood, Chris Schatschneider, Pradeep G. Bhide
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Developmental Biology
Lin Zhang, Cathy W. Levenson, Valentina Cea Salazar, Deirdre M. McCarthy, Joseph Biederman, Ross Zafonte, Pradeep G. Bhide
Summary: ADHD appears to increase the risk for transient depression following repeated mTBI, while repeated mTBI may be a risk factor for transient attention deficit.
DEVELOPMENTAL NEUROSCIENCE
(2021)