期刊
FEBS LETTERS
卷 583, 期 4, 页码 627-632出版社
WILEY
DOI: 10.1016/j.febslet.2009.01.012
关键词
Wnt; Kaiso; Xenopus
资金
- American Cancer Society Ohio Division
- Uehara Memorial Foundation
The Wnt family of secreted ligands plays critical roles during embryonic development and tumorigenesis. Here we show that Kaiso, a dual specific DNA-binding protein, functions as a bimodal regulator of canonical Wnt signaling. Loss-of-function analysis of Kaiso abrogated Wnt-mediated reporter activity and axis duplication, whereas gain-of-function analysis of Kaiso dose-dependently resulted in synergistic and suppressive effects. Our analyses further suggest Kaiso can regulate TCF/LEF1-activity for these effects via modulating HDAC1 and beta-catenin-complex formation. Our studies together provide insights into why Kaiso null mice display resistance to intestinal tumors when crossed onto an Apc(Min/+) background. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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