Article
Biochemistry & Molecular Biology
Raul Riquelme, Laura Li, Abigail Gambrill, Andres Barria
Summary: Wnt signaling is crucial for regulating synaptic and neuronal function in the mature CNS. Our study demonstrates that the Wnt receptor ROR2 can independently activate downstream signaling and regulate key synaptic components through homodimerization. Understanding ROR2 signaling is important for comprehending the regulation of synaptic and neuronal function in normal brain processes.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Manuel Schmidt, Christine Poser, Christina Janster, Julia von Maltzahn
Summary: The hairpin region of WNT7A in its C-terminus is fully sufficient to induce non-canonical signaling in myogenic cells, leading to hypertrophy, expansion of satellite stem cells, and migration of myoblasts. The linker region in the C-terminus of WNT7A binds to the FZD7 receptor but does not activate non-canonical Wnt signaling. The hairpin and linker regions of WNT7A can independently activate canonical Wnt signaling.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Neurosciences
Sheng Zhang, Yan Wang, Xiaoqing Zhu, Lanying Song, Xinhua Zhan, Edric Ma, Jennifer McDonough, Hui Fu, Franca Cambi, Judith Grinspan, Fuzheng Guo
Summary: The study reveals that TCF7l2 promotes OL differentiation by repressing BMP4 gene transcription, reducing autocrine BMP4 secretion, and dampening BMP4 signaling. Specific deletion of BMP4 can rescue arrested OL differentiation caused by TCF7l2 disruption in the oligodendroglial lineage.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Fuxing Dong, Dajin Liu, Feiyu Jiang, Yaping Liu, Xiuxiang Wu, Xuebin Qu, Jing Liu, Yan Chen, Hongbin Fan, Ruiqin Yao
Summary: The research indicates that Foxg1 plays a crucial role in the proliferation and differentiation of oligodendrocyte precursor cells (OPCs) in demyelinating diseases. Foxg1 knockout decreases OPC proliferation and accelerates their differentiation into mature oligodendrocytes, possibly through regulation via the Wnt signaling pathway.
NEUROSCIENCE BULLETIN
(2021)
Article
Endocrinology & Metabolism
Lirong Liang, Tian Zeng, Youyi Zhao, Rui Lu, Baolin Guo, Rougang Xie, Wenjing Tang, Li Zhang, Zirui Mao, Xinyu Yang, Shengxi Wu, Yazhou Wang, Hui Zhang
Summary: Recent studies have shown that melatonin pretreatment significantly alleviated the synaptic deficiency, dysmyelination, and long-term learning impairment induced by neonatal repeated exposure to Sev. The protective effects of melatonin on synaptic development, myelination, and behavior performance were mediated by the MT1 receptor and involved the canonical Wnt signaling pathway. This suggests that melatonin may be a promising clinical intervention for improving the safety of pediatric Sev anesthesia.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Zhenpeng Dai, James Chen, Yuqian Chang, Angela M. Christiano
Summary: The study demonstrates that in the C3H/HeJ mouse model, JAK1-selective and JAK3-selective inhibitors can effectively induce hair regrowth and reduce AA-related inflammation, while JAK2-selective inhibitors show less efficacy.
Article
Neurosciences
Sheng Zhang, Yan Wang, Jie Xu, Bokyung Kim, Wenbin Deng, Fuzheng Guo
Summary: This study reveals the important role of HIF-alpha in developmental myelination, demonstrating its requirement in controlling OPC differentiation for efficient myelination. Contrary to previous beliefs, it was found that HIF-alpha's regulation of CNS myelination is independent of canonical Wnt signaling, and instead involves the HIF-alpha-Sox9 regulatory axis. This discovery represents a shift in understanding the mechanisms of HIF-alpha-regulated CNS myelination from a Wnt-dependent view to a Wnt-independent one.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Cell Biology
Irena Smaga
Summary: This review summarizes the current knowledge on the role of myelin-related changes in depression, as well as the relationship among maternal malnutrition, myelination, and depression. The findings suggest that myelin alterations play a significant role in the development of depression.
Article
Biochemistry & Molecular Biology
Ebru S. Selen, Michael J. Wolfgang
Summary: The study revealed that activation of mTORC1 by deleting TSC1 in the liver is not enough to suppress PPAR alpha signaling or ketogenesis after fasting.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Oncology
Karol D. D. Urbanek, Stephan Stilgenbauer, Daniel Mertens
Summary: This review summarizes the current state of WNT signaling in chronic lymphocytic leukemia (CLL), focusing on the role of beta-catenin-independent and beta-catenin-dependent signaling in CLL cells. The overexpression of WNT ligands and receptors in CLL makes WNT pathways a potential therapeutic target, either alone or in combination with other drugs. Further research is needed to fully understand the role of beta-catenin signaling in CLL.
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Review
Developmental Biology
Ruizhi Xue, Wenfeng Lin, Jingkai Sun, Masami Watanabe, Abai Xu, Motoo Araki, Yasutomo Nasu, Zhengyan Tang, Peng Huang
Summary: Accumulating evidence indicates that Wnt signaling is closely related to male reproductive physiology, with dysfunction potentially leading to pathological changes in genital organs and sperm cells. Despite numerous abnormalities being found in knockout models, research has mostly focused on individual factors within the Wnt pathway, with few reports on the overall relationship between Wnt signals and male reproductive physiology. This review aims to provide an overview of Wnt signaling in male reproductive physiology and pathology, sorting out relevant functions and addressing controversies among different studies.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Agriculture, Dairy & Animal Science
Seon-Ung Hwang, Junchul David Yoon, Mirae Kim, Lian Cai, Hyerin Choi, Dongjin Oh, Eunhye Kim, Sang-Hwan Hyun
Summary: The RSPO2 and WNT/CTNNB1 signaling pathways are crucial for porcine follicle development, and are likely involved in the EGFR-ERK signaling pathway.
Article
Neurosciences
Eduardo Molina-Holgado, Pedro F. Esteban, Angel Arevalo-Martin, Rafael Moreno-Luna, Francisco Molina-Holgado, Daniel Garcia-Ovejero
Summary: Oligodendrocytes in the central nervous system synthesize myelin and have the ability to regulate their functions through interactions with other cells and sensing the environment. They respond to various signals, including the endocannabinoid signaling, which has therapeutic potential for promoting remyelination in central nervous system pathologies.
Review
Cell Biology
Willy Antoni Abreu de Oliveira, Youssef El Laithy, Alejandra Bruna, Daniela Annibali, Frederic Lluis
Summary: This review explores the role of the Wnt signaling pathway in mammary gland development and cancer, focusing on the interplay between its molecular network defects and breast cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Microbiology
Xin Zhu, Anshan Shan, Zhi Ma, Wei Xu, Jiajun Wang, Shuli Chou, Baojing Cheng
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Genetics & Heredity
Devanshi Mehta, Sarah E. Noon, Emily Schwartz, Alisha Wilkens, Emma C. Bedoukian, Irene Scarano, E. Bryan Crenshaw, Ian D. Krantz
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2016)
Article
Medical Informatics
Aaron J. Masino, Robert W. Grundmeier, Jeffrey W. Pennington, John A. Germiller, E. Bryan Crenshaw
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2016)
Article
Behavioral Sciences
Taylor Hatchard, Jaimee J. Ting, Claude Messier
BEHAVIOURAL BRAIN RESEARCH
(2014)
Article
Neurosciences
Andra M. Smith, Claude Messier
FRONTIERS IN HUMAN NEUROSCIENCE
(2014)
Article
Computer Science, Information Systems
Jeffrey W. Pennington, Byron Ruth, Michael J. Italia, Jeffrey Miller, Stacey Wrazien, Jennifer G. Loutrel, E. Bryan Crenshaw, Peter S. White
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2014)
Article
Neurosciences
Reno M. Gandhi, Cary S. Kogan, Claude Messier, Lindsey S. MacLeod
Review
Neurosciences
J. J. Boulanger, C. Messier
Article
Multidisciplinary Sciences
Steven Raft, Thomas M. Coate, Matthew W. Kelley, E. Bryan Crenshaw, Doris K. Wu
Article
Health Care Sciences & Services
Delyana Ivanova Miller, France Aube, Vincent Talbot, Michele Gagnon, Claude Messier
TELEMEDICINE AND E-HEALTH
(2014)
Article
Audiology & Speech-Language Pathology
Jeffrey W. Pennington, Byron Ruth, Jeffrey M. Miller, Joy Peterson, Baichen Xu, Aaron J. Masino, Ian Krantz, Juliana Manganella, Tamar Gomes, Derek Stiles, Margaret Kenna, Linda J. Hood, John Germiller, E. Bryan Crenshaw
Article
Multidisciplinary Sciences
Lihua Qin, Kyung J. Ahn, Lara Wine Lee, Charles de Charleroy, E. Bryan Crenshaw
Article
Neurosciences
Alexandria Beland-Millar, Masaki Takimoto, Taku Hamada, Claude Messier
Article
Audiology & Speech-Language Pathology
Jordan M. Racca, John Lee, Faith Sikorski, E. Bryan Crenshaw, Linda J. Hood
Summary: This study identified an association between cholesteatoma and progressive sensorineural hearing loss in children using a large pediatric longitudinal audiologic dataset. The findings suggest that children diagnosed with cholesteatoma may be at increased risk for progressive sensorineural hearing loss, even after initial normal hearing test results have been established.
Article
Behavioral Sciences
Jenna J. Boulanger, Claude Messier
BEHAVIOURAL BRAIN RESEARCH
(2017)