DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue

Disruption of Insulin Signaling in Myf5-Expressing Progenitors Leads to Marked Paucity of Brown Fat but Normal Muscle Development

(2015) Matthew D. Lynes et al.   ENDOCRINOLOGY

Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice

(2015) Xiaomeng Liu et al.   ENDOCRINOLOGY

DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice

(2015) Sally Yu Shi et al.   Nature Communications

Characterization of the Novel and Specific PI3K  Inhibitor NVP-BYL719 and Development of the Patient Stratification Strategy for Clinical Trials

(2014) C. Fritsch et al.   MOLECULAR CANCER THERAPEUTICS

Brown adipose tissue transplantation improves whole-body energy metabolism

(2013) Xiaomeng Liu et al.   CELL RESEARCH

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

(2013) Tim J. Schulz et al.   NATURE

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

(2012) Isabel Garcia-Cao et al.   CELL

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors

(2012) Joan Sanchez-Gurmaches et al.   Cell Metabolism

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

(2012) Ana Ortega-Molina et al.   Cell Metabolism

Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant

(2012) S. C. Gunawardana et al.   DIABETES

The Chaperone-assisted E3 Ligase C Terminus of Hsc70-interacting Protein (CHIP) Targets PTEN for Proteasomal Degradation

(2012) Syed Feroj Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity

(2012) Aparna Pal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptional Activation of Low-Density Lipoprotein Receptor Gene by DJ-1 and Effect of DJ-1 on Cholesterol Homeostasis

(2012) Shiori Yamaguchi et al.   PLoS One

PTEN in cancer, metabolism, and aging

(2012) Ana Ortega-Molina et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes

(2012) Deepak Jain et al.   Journal of Molecular Cell Biology

The E3 Ubiquitin Ligase Mind Bomb-2 (MIB2) Protein Controls B-cell CLL/Lymphoma 10 (BCL10)-dependent NF-κB Activation

(2011) Cinthia C. Stempin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice

(2011) Cheryl J. Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells

(2011) Kye-Young Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Akt1 in Mice Increases Energy Expenditure and Protects against Diet-Induced Obesity

(2011) M. Wan et al.   MOLECULAR AND CELLULAR BIOLOGY

WWP2 is an E3 ubiquitin ligase for PTEN

(2011) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

Cellular bioenergetics as a target for obesity therapy

(2010) Yu-Hua Tseng et al.   NATURE REVIEWS DRUG DISCOVERY

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulates PTEN Ubiquitination, Content, and Compartmentalization

(2009) Céline Van Themsche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

(2009) Hui Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential Effects of Protein Kinase B/Akt Isoforms on Glucose Homeostasis and Islet Mass

(2009) F. Buzzi et al.   MOLECULAR AND CELLULAR BIOLOGY

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

(2009) Shingo Kajimura et al.   NATURE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses

(2009) S. Vasseur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic determinants and molecular pathways in the pathogenesis of Type 2 diabetes

(2008) Wanzhu Jin et al.   CLINICAL SCIENCE

Genomic variants at the PINK1 locus are associated with transcript abundance and plasma nonesterified fatty acid concentrations in European whites

(2008) P. W. Franks et al.   FASEB JOURNAL