Article
Health Care Sciences & Services
Hyemi Hwang, Yeonjae Han, Geun-Young Park, Soohwan Lee, Hae-Yeon Park, Sun Im
Summary: This study investigated the effects of tDCS on swallowing function in individuals with different COMT gene polymorphisms. The results showed that individuals with COMT Val/Val polymorphism experienced improvement in swallowing motor function after tDCS, while those with COMT Met carrier group did not show significant changes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Agriculture, Multidisciplinary
Seul Hoo Lee, Bongsang Kim, Kyung-Jin Kim
Summary: The study reported the biochemical and structural analysis of COMT enzyme from Niastella koreensis, revealing that its activity is mainly influenced by magnesium ion, but also shows significant activity with copper and zinc ions. Structural analysis showed that the region near the SAM binding site undergoes conformational changes upon binding of the cosubstrate and the metal ion. Additionally, by developing variants, the activity and selectivity of NkCOMT can be enhanced.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Dong-Fang Zhao, Yu-Fan Fan, Fang-Yuan Wang, Fan-Bin Hou, Frank J. Gonzalez, Shi-Yang Li, Ping Wang, Yang-Liu Xia, Guang-Bo Ge, Ling Yang
Summary: The study identified Scutellariae radix as the most potent inhibitor of hCOMT among 53 herbal products. Specific chemicals like scutellarein, baicalein, and oroxylin A from the extract were found to be potent COMT inhibitors. These findings suggest the potential for developing more effective non-nitrocatechol COMT inhibitors for biomedical applications.
Article
Medicine, Research & Experimental
Andrea Polli, Jolien Hendrix, Kelly Ickmans, Jelena Bakusic, Manosij Ghosh, Dora Monteyne, Brigitte Velkeniers, Bram Bekaert, Jo Nijs, Lode Godderis
Summary: The study found associations between COMT haplotypes and DNA methylation, cytokine expression, and symptoms in patients with CFS/FM, but not specific to one condition. Significant differences were observed in increased DNA methylation in the MB-COMT promoter and decreased IFN-gamma expression in patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
Blandine Laferrere, Satchidananda Panda
Summary: Calorie restriction is recommended for obesity treatment but is difficult to sustain. Time-restricted eating is a low-cost and sustainable approach that improves metabolism by limiting the eating window.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Wataru Kadowaki, Ryo Miyata, Misa Fujinami, Yoshizumi Sato, Shigenori Kumazawa
Summary: The study found that Calendula officinalis leaves contain 10 compounds with inhibitory activities against neurotransmitter-related diseases, particularly Parkinson's disease and depression.
Article
Chemistry, Medicinal
Dong-Fang Zhao, Yu-Fan Fan, Hao-Nan Yu, Fan-bin Hou, Yan-Wei Xiang, Ping Wang, Guang-Bo Ge, Ling Yang, Jian-Guang Xu
Summary: The study revealed that the flavonoids in vine tea exhibit strong inhibition against human catechol-Omethyltransferase, with myricetin being the most potent compound. This finding not only has implications for the drug exposure of catechol drugs, but also provides a promising lead compound for developing more effective hCOMT inhibitors.
Article
Biochemistry & Molecular Biology
Jin-Hee Kim, Jimin Lee, Hyesoo Jeong, Mi Seo Bang, Jin-Hyun Jeong, Minsun Chang
Summary: The study investigated the novel biological activities of NDGA in relation to COMT and how COMT inhibition by NDGA affects 4-OHE2-induced cyto- and genotoxicity in MCF-7 human breast cancer cells. The results showed that NDGA both inhibits COMT-mediated formation of 4-MeOE2 and increases 4-OHE2-induced DNA damage and cytotoxicity, potentially increasing catechol estrogen-induced genotoxicities in mammary tissues.
Article
Biotechnology & Applied Microbiology
Olga A. Korczeniewska, Fengshen Kuo, Ching-Yu Huang, Cibele Nasri-Heir, Junad Khan, Rafael Benoliel, Craig Hirschberg, Eli Eliav, Scott R. Diehl
Summary: This study investigated the impact of the COMT gene on pain sensitivity and found that the low pain sensitivity haplotype is influenced by genetic variation in gene expression, rather than SNP rs4680. The results suggest that the frequency of the COMT low pain sensitivity haplotype varies widely among global populations.
JOURNAL OF GENE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
K. Poonkuzhali, R. Seenivasagan, J. Prabhakaran, A. Karthika
Summary: Chemically engineered PLGA nanospheres inhibiting Catechol-O-methyltransferase (COMT) are a promising technology for treating neurodegenerative disorders. PLGA-MATPM nanospheres, synthesized using PLGA and MATPM, effectively inhibit COMT in a dose-dependent manner. The interaction between COMT and PLGA nanospheres is explained through spectroscopic and molecular dynamics analysis. PLGA-MATPM nanospheres show neurodegenerative recovery by suppressing the growth of neuroblastoma cells and effectively cross the blood-brain barrier.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Daniel Chavarria, Sofia Benfeito, Pedro Soares, Carla Lima, Jorge Garrido, Paula Serra, Patricio Soares-da-Silva, Fernando Remia, Paulo J. Oliveira, Fernanda Borges
Summary: CA derivatives have antioxidant properties and inhibitory effects on MAOs and COMT. They can protect cells against oxidative damage, but may induce ROS generation and cytotoxic effects at high concentrations. Some compounds can cross the blood-brain barrier, potentially aiding in restoring DA neurotransmission and preventing PD.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Fang-Yuan Wang, Ping Wang, Dong-Fang Zhao, Frank J. Gonzalez, Yu-Fan Fan, Yang-Liu Xia, Guang-Bo Ge, Ling Yang
Summary: This review summarizes recent advances in analytical methodologies for sensing COMT activity and their applications, while highlighting challenges and future perspectives in the field. The practical assays for measuring COMT activities in complex biological samples are crucial for investigating the relevance of COMT to human diseases and promoting the discovery of COMT inhibitors via high-throughput screening.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Ana M. Goncalves, Augusto Q. Pedro, Diana M. Oliveira, Adriana E. Oliveira, Marino F. A. Santos, Marcia A. S. Correia, Joao A. Queiroz, Eugenia Gallardo, Maria J. Romao, Luis A. Passarinha
Summary: This study characterized the thermal stability of SCOMT and found potential conditions and additives that can increase its stability and activity recovery rate. By using an ionic liquid and other additives, protein solubility and melting temperature were significantly improved, paving the way for further research and therapeutic molecule design.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ana M. Goncalves, Angela Sousa, Augusto Q. Pedro, Maria J. Romao, Joao A. Queiroz, Eugenia Gallardo, Luis A. Passarinha
Summary: Membrane-bound catechol-O-methyltransferase (MBCOMT) is a pharmacological target related to several types of human dementia, but its instability has hindered drug development. The addition of multi-component buffers and ionic liquids has shown promising results in enhancing the stability of MBCOMT and has important implications for drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Ryo Miyata, Sara Hoshino, Mok-Ryeon Ahn, Shigenori Kumazawa
Summary: Bee pollen contains compounds that can competitively inhibit the neurotransmitter COMT, which is associated with Parkinson's disease and depression. This study analyzed the chemical composition of Korean bee pollens and identified key compounds with inhibitory properties. The findings suggest that bee pollen could be used for the prevention and treatment of these diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Ophthalmology
Aldina Pivodic, Anna-Lena Hard, Chatarina Lofqvist, Lois E. H. Smith, Carolyn Wu, Marie-Christine Brunder, Wolf A. Lagreze, Andreas Stahl, Gerd Holmstrom, Kerstin Albertsson-Wikland, Helena Johansson, Staffan Nilsson, Ann Hellstrom
JAMA OPHTHALMOLOGY
(2020)
Article
Neurosciences
Jakob Naslund, Erik Studer, Staffan Nilsson, Elias Eriksson
ACTA NEUROPSYCHIATRICA
(2020)
Letter
Hematology
Malin S. Nilsson, Alexander Hallner, Mats Brune, Staffan Nilsson, Fredrik B. Thoren, Anna Martner, Kristoffer Hellstrand
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Article
Ophthalmology
Aldina Pivodic, Staffan Nilsson, Andreas Stahl, Lois E. H. Smith, Ann Hellstrom
Summary: The study validated the Retinopathy of Prematurity Activity Scale (ROP-ActS) in a screened cohort and found that the modified ROP-ActS was superior in predicting ROP treatment compared to traditional ROP stage and zone. Additionally, the scale showed a stronger relationship with gestational age than the conventional ROP stage.
ACTA OPHTHALMOLOGICA
(2021)
Article
Immunology
Aylin Yilmaz, Emelie Marklund, Maria Andersson, Staffan Nilsson, Lars-Magnus Andersson, Magnus Lindh, Magnus Gisslen
Summary: The study found that viral RNA loads were highest early after symptom onset, and there was a moderate correlation between duration of symptoms and viral RNA shedding in patients with mild COVID-19.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Letter
Immunology
Johan Ringlander, Staffan Nilsson, Johan Westin, Magnus Lindh, Anna Martner, Kristoffer Hellstrand
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Hematology
Martina Olsson Lindvall, Annelie Angerfors, Bjoern Andersson, Staffan Nilsson, Marcela Davila Lopez, Lena Hansson, Tara M. Stanne, Christina Jern
Summary: DNA methylation plays a crucial role in the pathogenesis of diseases, with blood samples not always accurately reflecting tissue-specific methylation patterns. Research indicates moderate to strong correlations between blood and liver DNA methylation at specific CpG sites, suggesting potential for using blood as a proxy for liver methylation at certain genomic loci.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Multidisciplinary Sciences
Erika Tyrberg, Arvid Eden, Jaran Eriksen, Staffan Nilsson, Carl Johan Treutiger, Anders Thalme, Asa Mellgren, Magnus Gisslen, Lars-Magnus Andersson
Summary: In this study, it was found that elderly PLHIV aged >= 65 years had higher steady-state plasma levels of DRV and ATV compared to controls <= 49 years of age, while no significant differences were observed in the EFV arm. The DRV arm had a higher frequency of reported side effects compared to the ATV and EFV arms in the study group.
Article
Medicine, General & Internal
Johanna Wiik, Staffan Nilsson, Cecilia Karrberg, Bjorn Strander, Bo Jacobsson, Verena Sengpiel
Summary: The study shows an association between HPV infection, CIN treatment, and adverse pregnancy outcomes, suggesting that women with these conditions before or during pregnancy should be carefully managed to reduce risks.
Article
Pediatrics
Kjersti Kvernebo Sunnergren, Ann-Katrine Karlsson, Kerstin Allvin, Staffan Nilsson, Carina Ankarberg-Lindgren, Jovanna Dahlgren
Summary: This study found that adrenal androgen concentrations in boys born moderate to late preterm were correlated with weight and waist-to-height ratios during childhood from 5 to 10 years of age, suggesting that body composition plays a more significant role in adrenal androgen secretion than gestational age and birth size.
Article
Medicine, General & Internal
Johanna Wiik, Cecilia Karrberg, Staffan Nilsson, Bjorn Strander, Bo Jacobsson, Verena Sengpiel
Summary: This study reveals that excisional treatment of cervical intraepithelial neoplasia (CIN) is associated with increased risk of preterm delivery, especially with larger cone lengths. Clinicians should aim to remove all CIN while preserving healthy cervical tissue in women of reproductive age.
Article
Obstetrics & Gynecology
Linda Englund Ogge, Fiona Murray, Dominika Modzelewska, Robert Lundqvist, Staffan Nilsson, Helena Carre, Maria Kippler, Agnes E. Wold, Ann-Sofie Sandberg, Anna Sandin, Bo Jacobsson, Malin Barman
Summary: This study investigates the potential bias due to self-selection in the NICE birth cohort in Sweden and finds that self-selection has minimal impact on the study's outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Kjersti Kvernebo Sunnergren, Jovanna Dahlgren, Ann-Katrine Karlsson, Staffan Nilsson, Kerstin Allvin, Carina Ankarberg-Lindgren
Summary: This study found that lower birth weight was associated with increased sex hormone concentrations during childhood. Weight gain after birth was positively correlated with sex hormone concentrations.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Rehabilitation
Idor Svensson, Thomas Nordstrom, Emma Lindeblad, Stefan Gustafson, Marianne Bjorn, Christina Sand, Gunilla Almgren-Back, Staffan Nilsson
Summary: Assistive technology can have positive effects on students with severe reading disabilities, especially for those facing the most challenges. While there was no significant difference in progress between the intervention and control groups within one year, assistive technology appears to enhance reading ability and overall motivation for learning.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Dominika Modzelewska, Pol Sole-Navais, Anna Sandstrom, Ge Zhang, Louis J. Muglia, Christopher Flatley, Staffan Nilsson, Bo Jacobsson
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)