Translating the Hypoxic Response—the Role of HIF Protein Translation in the Cellular Response to Low Oxygen

miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target

(2018) Marcin Serocki et al.   ANGIOGENESIS

Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases

(2018) Amit A. Joharapurkar et al.   JOURNAL OF MEDICINAL CHEMISTRY

PERK/eIF2α signaling inhibits HIF-induced gene expression during the unfolded protein response via YB1-dependent regulation of HIF1α translation

(2018) Iglika G Ivanova et al.   NUCLEIC ACIDS RESEARCH

Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis

(2018) Huichun Liang et al.   ONCOGENE

Cold-inducible RNA binding protein in cancer and inflammation

(2018) Daniel A. Lujan et al.   Wiley Interdisciplinary Reviews-RNA

Regulation of microRNA function in animals

(2018) Luca F. R. Gebert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin

(2018) James A Smythies et al.   EMBO REPORTS

miRNA networks modulate human endothelial cell adaptation to cyclic hypoxia

(2018) Kinga Kochan-Jamrozy et al.   CELLULAR SIGNALLING

Cytoplasmic overexpression of RNA-binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia

(2017) Guillaume Gauchotte et al.   JOURNAL OF PATHOLOGY

An emergency brake for protein synthesis

(2017) Vladislava Hronová et al.   eLife

Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

(2017) Pramod Kumar Maurya et al.   Journal of Cancer

MiR-150 regulates human keratinocyte proliferation in hypoxic conditions through targeting HIF-1α and VEGFA: Implications for psoriasis treatment

(2017) Yongjian Li et al.   PLoS One

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

Translational control by 5'-untranslated regions of eukaryotic mRNAs

(2016) A. G. Hinnebusch et al.   SCIENCE

Dysregulation of TTP and HuR plays an important role in cancers

(2016) Hao Wang et al.   TUMOR BIOLOGY

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

(2016) Julianty Frost et al.   Nature Communications

Role of Mir-155 in Controlling HIF-1α Level and Promoting Endothelial Cell Maturation

(2016) Deguang Yang et al.   Scientific Reports

miR-429 regulates the transition between Hypoxia-Inducible Factor (HIF)1A and HIF3A expression in human endothelial cells

(2016) Anna Janaszak-Jasiecka et al.   Scientific Reports

Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis

(2015) Amal M. El-Naggar et al.   CANCER CELL

HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine

(2015) T. Bishop et al.   CIRCULATION RESEARCH

The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1α expression in human endothelial cells through a negative feedback loop

(2015) Sylwia Bartoszewska et al.   FASEB JOURNAL

YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1

(2015) Syam Prakash Somasekharan et al.   JOURNAL OF CELL BIOLOGY

Translating the Untranslated Region

(2015) Johannes Schwerk et al.   JOURNAL OF IMMUNOLOGY

Structural integration in hypoxia-inducible factors

(2015) Dalei Wu et al.   NATURE

Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum

(2015) Jonas J. Staudacher et al.   NUCLEIC ACIDS RESEARCH

Genome-wide analysis of YB-1-RNA interactions reveals a novel role of YB-1 in miRNA processing in glioblastoma multiforme

(2015) Shuai-Lai Wu et al.   NUCLEIC ACIDS RESEARCH

CPEB1 mediates epithelial-to-mesenchyme transition and breast cancer metastasis

(2015) K Nagaoka et al.   ONCOGENE

miR-497 suppresses angiogenesis in breast carcinoma by targeting HIF-1α

(2015) ZHIHAO WU et al.   ONCOLOGY REPORTS

microRNA-18a regulates gastric carcinoma cell apoptosis and invasion by suppressing hypoxia-inducible factor-1α expression

(2015) FUBING WU et al.   Experimental and Therapeutic Medicine

Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNA-binding protein and a p53 family target, via mRNA translation

(2015) Seong-Jun Cho et al.   Oncotarget

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The N-terminal region of p27 inhibits HIF-1α protein translation in ribosomal protein S6-dependent manner by regulating PHLPP-Ras-ERK-p90RSK axis

(2014) D Zhang et al.   Cell Death & Disease

Tristetraprolin (TTP): Interactions with mRNA and proteins, and current thoughts on mechanisms of action

(2013) Seth A. Brooks et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2  mRNA translation

(2013) N. Wilkinson et al.   BLOOD

The eIF2α kinases: their structures and functions

(2013) Neysan Donnelly et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein

(2013) Maria Romanelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RNPC1, an RNA-binding Protein and a p53 Target, Regulates Macrophage Inhibitory Cytokine-1 (MIC-1) Expression through mRNA Stability

(2013) Tiffany Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restricted Expression of miR-30c-2-3p and miR-30a-3p in Clear Cell Renal Cell Carcinomas Enhances HIF2  Activity

(2013) L. K. Mathew et al.   Cancer Discovery

YB-1 protein: functions and regulation

(2013) Dmitry N. Lyabin et al.   Wiley Interdisciplinary Reviews-RNA

Tristetraprolin: Roles in cancer and senescence

(2012) Christina R. Ross et al.   AGEING RESEARCH REVIEWS

Y-box-binding protein 1 (YB-1) and its functions

(2012) I. A. Eliseeva et al.   BIOCHEMISTRY-MOSCOW

Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction

(2012) Seul Gi Kang et al.   CARCINOGENESIS

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

An oxygen-regulated switch in the protein synthesis machinery

(2012) James Uniacke et al.   NATURE

MicroRNA-145 inhibits the growth, invasion, metastasis and angiogenesis of neuroblastoma cells through targeting hypoxia-inducible factor 2 alpha

(2012) H Zhang et al.   ONCOGENE

Passing the baton: the HIF switch

(2012) Mei Yee Koh et al.   TRENDS IN BIOCHEMICAL SCIENCES

HIF-1 versus HIF-2 — Is one more important than the other?

(2012) Agnieszka Loboda et al.   VASCULAR PHARMACOLOGY

Principles of Translational Control: An Overview

(2012) J. W. B. Hershey et al.   Cold Spring Harbor Perspectives in Biology

Hypoxia elicits broad and systematic changes in protein subcellular localization

(2011) Robert Michael Henke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The role of tristetraprolin in cancer and inflammation

(2011) Sandhya Sanduja   Frontiers in Bioscience-Landmark

Hypoxia-inducible factor-1α mRNA: a new target for destabilization by tristetraprolin in endothelial cells

(2011) Sandrine Chamboredon et al.   MOLECULAR BIOLOGY OF THE CELL

Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR

(2011) Svetlana Lebedeva et al.   MOLECULAR CELL

Translational control is a major contributor to hypoxia induced gene expression

(2011) Twan van den Beucken et al.   RADIOTHERAPY AND ONCOLOGY

The role of IREStrans-acting factors in regulating translation initiation

(2010) Helen A. King et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Connectivity Map Links Iron Regulatory Protein-1-Mediated Inhibition of Hypoxia-Inducible Factor-2a Translation to the Anti-inflammatory 15-deoxy- 12,14-Prostaglandin J2

(2010) M. Zimmer et al.   CANCER RESEARCH

MicroRNA-519c Suppresses Hypoxia-Inducible Factor-1α Expression and Tumor Angiogenesis

(2010) Shih-Ting Cha et al.   CANCER RESEARCH

Role of the hypoxia inducible factors HIF in iron metabolism

(2010) Carole Peyssonnaux et al.   CELL CYCLE

Biological functions of microRNAs: a review

(2010) Yong Huang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Inhibition of Hypoxia-Inducible Factor-1α (HIF-1α) Protein Synthesis by DNA Damage Inducing Agents

(2010) Jessica Jie Wei Lou et al.   PLoS One

P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis

(2010) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of CPEB, GAPDH and U6snRNA in cervical and ovarian tissue during cancer development

(2009) CHRISTINA NEIGAARD HANSEN et al.   APMIS

Tristetraprolin regulates the stability of HIF-1α mRNA during prolonged hypoxia

(2009) Tae Woo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Translational Activation of Snail1 and Other Developmentally Regulated Transcription Factors by YB-1 Promotes an Epithelial-Mesenchymal Transition

(2009) Valentina Evdokimova et al.   CANCER CELL

The mRNA-Destabilizing Protein Tristetraprolin Is Suppressed in Many Cancers, Altering Tumorigenic Phenotypes and Patient Prognosis

(2009) S. E. Brennan et al.   CANCER RESEARCH

mRNA Localization: Gene Expression in the Spatial Dimension

(2009) Kelsey C. Martin et al.   CELL

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Factors Interacting with HIF-1α mRNA: Novel Therapeutic Targets

(2009) Stefanie Galban et al.   CURRENT PHARMACEUTICAL DESIGN

Surviving hypoxia by modulation of mRNA translation rate

(2009) Michael Fähling   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration

(2009) Zhang Lei et al.   PLoS One

Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells

(2009) Shi-Hua Liao et al.   PROTEOMICS

Subcellular mRNA Localization in Animal Cells and Why It Matters

(2009) C. E. Holt et al.   SCIENCE

Regulation of gene expression by hypoxia

(2008) Niall Steven Kenneth et al.   BIOCHEMICAL JOURNAL

Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to theHIF-1α mRNA 3′-UTR and modulate HIF-1α protein expression

(2008) Sonja Hägele et al.   BIOCHEMICAL JOURNAL

Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein

(2008) Kirsty Sawicka et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Identification of Hypoxia-Inducible Factor-1  as a Novel Target for miR-17-92 MicroRNA Cluster

(2008) A. Taguchi et al.   CANCER RESEARCH

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Hypoxia-mediated Selective mRNA Translation by an Internal Ribosome Entry Site-independent Mechanism

(2008) Regina M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-Molecule Inhibitors of HIF-2a Translation Link Its 5′UTR Iron-Responsive Element to Oxygen Sensing

(2008) Michael Zimmer et al.   MOLECULAR CELL

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional responses to intermittent hypoxia

(2008) Jayasri Nanduri et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY