IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2  mRNA translation

The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

(2013) Sheila A. Anderson et al.   Cell Metabolism

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

(2013) Manik C. Ghosh et al.   Cell Metabolism

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis

(2012) A. Laitala et al.   BLOOD

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Molecular insights into the regulation of iron metabolism during the prenatal and early postnatal periods

(2012) Paweł Lipiński et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis

(2012) Qingdu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

eIF4F suppression in breast cancer affects maintenance and progression

(2012) Z Nasr et al.   ONCOGENE

Regulation of cellular iron metabolism

(2011) Jian Wang et al.   BIOCHEMICAL JOURNAL

Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression

(2011) V. R. Gordeuk et al.   BLOOD

Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

(2011) M. Mastrogiannaki et al.   HAEMATOLOGICA

Conditional disruption of mouse HFE2 gene: Maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin

(2011) Konstantinos Gkouvatsos et al.   HEPATOLOGY

Hypoxia Inducible Factor-2α Is Translationally Repressed in Response to Dietary Iron Deficiency in Sprague-Dawley Rats

(2011) McKale R. Davis et al.   JOURNAL OF NUTRITION

Accelerated CCl4-Induced Liver Fibrosis in Hjv-/- Mice, Associated with an Oxidative Burst and Precocious Profibrogenic Gene Expression

(2011) Giada Sebastiani et al.   PLoS One

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

(2010) P. P. Kapitsinou et al.   BLOOD

The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice

(2010) Michele M. Hickey et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumorigenic Properties of Iron Regulatory Protein 2 (IRP2) Mediated by Its Specific 73-Amino Acids Insert

(2010) Carmen Maffettone et al.   PLoS One

Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli

(2009) H. Huang et al.   BLOOD

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-inducible factor-2α-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization

(2009) Alexander Paliege et al.   KIDNEY INTERNATIONAL

An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis

(2009) A. A. Salahudeen et al.   SCIENCE

Control of Iron Homeostasis by an Iron-Regulated Ubiquitin Ligase

(2009) A. A. Vashisht et al.   SCIENCE

Small-Molecule Inhibitors of HIF-2a Translation Link Its 5′UTR Iron-Responsive Element to Oxygen Sensing

(2008) Michael Zimmer et al.   MOLECULAR CELL

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

(2008) Valentina Gandin et al.   NATURE

PHD2Mutation and Congenital Erythrocytosis with Paraganglioma

(2008) Charline Ladroue et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Gain-of-Function Mutation in theHIF2AGene in Familial Erythrocytosis

(2008) Melanie J. Percy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

(2007) K. Takeda et al.   BLOOD

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

(2007) Y. A. Minamishima et al.   BLOOD