27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells

Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion

(2018) Elisabet Barbero-Camps et al.   Autophagy

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Axonal transport and maturation of lysosomes

(2018) Shawn M Ferguson   CURRENT OPINION IN NEUROBIOLOGY

Leptospira interrogans infection leads to IL-1β and IL-18 secretion from a human macrophage cell line through reactive oxygen species and cathepsin B mediated-NLRP3 inflammasome activation

(2018) Shijun Li et al.   MICROBES AND INFECTION

The significance of cholesterol and its metabolite, 27-hydroxycholesterol in breast cancer

(2018) Erik R. Nelson   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Increased Levels of 27-Hydroxycholesterol Induced by Dietary Cholesterol in Brain Contribute to Learning and Memory Impairment in Rats

(2018) Xiaona Zhang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway

(2018) Yong Ni et al.   NEUROSCIENCE

Neuronal lysosomes

(2018) Shawn M. Ferguson   NEUROSCIENCE LETTERS

A Free Radical-Generating System Regulates Amyloid Oligomers: Involvement of Cathepsin B

(2018) Patricia Llorente et al.   JOURNAL OF ALZHEIMERS DISEASE

Donepezil effects on cholesterol and oxysterol plasma levels of Alzheimer’s disease patients

(2017) Alana C. Costa et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Differential redox sensitivity of cathepsin B and L holds the key to autophagy-apoptosis interplay after Thioredoxin reductase inhibition in nutritionally stressed SH-SY5Y cells

(2017) Pandian Nagakannan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation

(2017) Gregory M. Orlowski et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Molecular mechanisms of gallic acid-induced growth inhibition, apoptosis, and necrosis in hypertrophic scar fibroblasts

(2017) Shu-Chung Hsieh et al.   LIFE SCIENCES

Cholesterol as a modifying agent of the neurovascular unit structure and function under physiological and pathological conditions

(2017) Ewelina Czuba et al.   METABOLIC BRAIN DISEASE

27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells

(2017) Yu An et al.   NEUROTOXICOLOGY

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Intracellular Cholesterol Trafficking and Impact in Neurodegeneration

(2017) Fabian Arenas et al.   Frontiers in Molecular Neuroscience

Lysosome and endoplasmic reticulum quality control pathways in Niemann-Pick type C disease

(2016) Mark L. Schultz et al.   BRAIN RESEARCH

Lysosomal Acid Phosphatase Biosynthesis and Dysfunction: A Mini Review Focused on Lysosomal Enzyme Dysfunction in Brain

(2016) N. Ashtari et al.   CURRENT MOLECULAR MEDICINE

Inflammasome Involvement in Alzheimer’s Disease

(2016) Ingar Olsen et al.   JOURNAL OF ALZHEIMERS DISEASE

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

The cytotoxicity of 27-hydroxycholesterol in co-cultured SH-SY5Y cells and C6 cells

(2016) Hui Wang et al.   NEUROSCIENCE LETTERS

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis: role in pulmonary inflammation following LPS

(2016) Jie Yang et al.   Cell Death & Disease

Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway

(2016) Joshua H. K. Tam et al.   PLoS One

Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins

(2016) Stjepko Cermak et al.   PLoS One

Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease

(2015) Ana Serrano-Puebla et al.   Annals of the New York Academy of Sciences

Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents

(2015) Jürgen Brojatsch et al.   CELL CYCLE

Gasdermin D: the long-awaited executioner of pyroptosis

(2015) Si Ming Man et al.   CELL RESEARCH

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

The autophagic- lysosomal pathway determines the fate of glial cells under manganese- induced oxidative stress conditions

(2015) RM Gorojod et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The Oxysterol 27-Hydroxycholesterol Increases Oxidative Stress and Regulate Nrf2 Signaling Pathway in Astrocyte Cells

(2015) Wei-Wei Ma et al.   NEUROCHEMICAL RESEARCH

27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain

(2015) D.-D. Zhang et al.   NEUROSCIENCE

Ethanol directly induced HMGB1 release through NOX2/NLRP1 inflammasome in neuronal cells

(2015) Xiaolan Wang et al.   TOXICOLOGY

Lysosomal membrane permeabilization in cell death: Concepts and challenges

(2014) Urška Repnik et al.   MITOCHONDRION

Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease

(2013) Julius Popp et al.   BIOCHEMICAL PHARMACOLOGY

Fodipir and Its Dephosphorylated Derivative Dipyridoxyl Ethyldiamine Are Involved in Mangafodipir-Mediated Cytoprotection against 7�-Hydroxycholesterol-Induced Cell Death

(2013) Amit Laskar et al.   PHARMACOLOGY

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

Lysosomal Membrane Permeabilization as a Key Player in Brain Ischemic Cell Death: a “Lysosomocentric” Hypothesis for Ischemic Brain Damage

(2013) Peter Lipton   Translational Stroke Research

Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease

(2012) Julius Popp et al.   JOURNAL OF NEUROCHEMISTRY

Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms

(2012) A. Besga et al.   NEUROSCIENCE LETTERS

Lysosomal Function and Dysfunction: Mechanism and Disease

(2011) Patricia Boya   ANTIOXIDANTS & REDOX SIGNALING

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Whole body cholesterol metabolism is impaired in Huntington's disease

(2011) V. Leoni et al.   NEUROSCIENCE LETTERS

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

(2011) Seth L. Masters et al.   TRENDS IN MOLECULAR MEDICINE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease

(2009) Ian J. Martins et al.   JOURNAL OF NEUROCHEMISTRY

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE