Lysosomal Membrane Permeabilization as a Key Player in Brain Ischemic Cell Death: a “Lysosomocentric” Hypothesis for Ischemic Brain Damage

Apoptosis meets autophagy-like cell death in the ischemic penumbra: Two sides of the same coin?

(2014) Abdelhaq Rami et al.   Autophagy

GX15-070 (Obatoclax) Induces Apoptosis and Inhibits Cathepsin D- and L-Mediated Autophagosomal Lysis in Antiestrogen-Resistant Breast Cancer Cells

(2013) J. L. Schwartz-Roberts et al.   MOLECULAR CANCER THERAPEUTICS

Lipids and Lysosomes

(2012) Isabelle Hamer et al.   CURRENT DRUG METABOLISM

Reduced cathepsins B and D cause impaired autophagic degradation that can be almost completely restored by overexpression of these two proteases in Sap C-deficient fibroblasts

(2012) M. Tatti et al.   HUMAN MOLECULAR GENETICS

A Nonlinear Dynamical Theory of Cell Injury

(2012) Donald J DeGracia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells

(2012) Chiara Ullio et al.   JOURNAL OF LIPID RESEARCH

The Roles of Neutral Sphingomyelinases in Neurological Pathologies

(2012) Charles R. Horres et al.   NEUROCHEMICAL RESEARCH

Reperfusion Promotes Mitochondrial Dysfunction following Focal Cerebral Ischemia in Rats

(2012) Jun Li et al.   PLoS One

Severe Global Cerebral Ischemia-Induced Programmed Necrosis of Hippocampal CA1 Neurons in Rat Is Prevented by 3-Methyladenine: A Widely Used Inhibitor of Autophagy

(2011) Jin-Ye Wang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Adenovirus Type 5 Rupture of Lysosomes Leads to Cathepsin B-Dependent Mitochondrial Stress and Production of Reactive Oxygen Species

(2011) K. A. McGuire et al.   JOURNAL OF VIROLOGY

Regulation of apoptosis-associated lysosomal membrane permeabilization

(2010) Ann-Charlotte Johansson et al.   APOPTOSIS

Calpain-mediated Hsp70.1 cleavage in hippocampal CA1 neuronal death

(2010) Shunya Sahara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes

(2010) C Oberle et al.   CELL DEATH AND DIFFERENTIATION

Nonesterified cholesterol content of lysosomes modulates susceptibility to oxidant-induced permeabilization

(2010) John J. Reiners et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosomal rupture, necroapoptotic interactions and potential crosstalk between cysteine proteases in neurons shortly after focal ischemia

(2010) Münire Kilinc et al.   NEUROBIOLOGY OF DISEASE

Postischemic treatment of neonatal cerebral ischemia should target autophagy

(2009) Julien Puyal et al.   ANNALS OF NEUROLOGY

Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions

(2009) Silvia Jordans et al.   BMC BIOCHEMISTRY

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial membrane permeabilization in neuronal injury

(2009) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

Melanin-concentrating hormone induces neurite outgrowth in human neuroblastoma SH-SY5Y cells through p53 and MAPKinase signaling pathways

(2009) Natacha Cotta-Grand et al.   PEPTIDES

The role of lysosomal rupture in neuronal death

(2009) Tetsumori Yamashima et al.   PROGRESS IN NEUROBIOLOGY

Lysosomal release of cathepsins causes ischemic damage in the rat hippocampal slice and depends on NMDA-mediated calcium influx, arachidonic acid metabolism, and free radical production

(2008) James A. Windelborn et al.   JOURNAL OF NEUROCHEMISTRY

Zinc and 4-Hydroxy-2-Nonenal Mediate Lysosomal Membrane Permeabilization Induced by H2O2 in Cultured Hippocampal Neurons

(2008) J. J. Hwang et al.   JOURNAL OF NEUROSCIENCE

Myocardial ischemia and reperfusion injury in rats: lysosomal hydrolases and matrix metalloproteinases mediated cellular damage

(2008) Mitali Tiwari et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE